Genetic disposition and modifiable factors independently associated with anemia in patients with type 2 diabetes mellitus

Chiou, Terry Ting-Yu; Lee, Jong‐Jer; Wang, Ming-Chung; Chung, Min-Shien; Pan, Linlin; Hsieh, Ching‐Chuan; Huang, Siang-Ting; Chang, Hsueh‐Wen; Yang, Kuender D.; Lee, Chien-Te; Liu, Rue‐Tsuan

doi:10.1016/j.diabres.2014.12.012

Cited by 8 publications

(6 citation statements)

References 29 publications

(24 reference statements)

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“…Interestingly, in addition, it was clear that the haematological indices measured, which included the RBC and platelet count as well as the plateletcrit, were reduced in HFD-fed mice, when compared to the controls. Consistent with previous evidence, anaemia is common in overweight and obese states [17,18,19,20], however, little is known on the relationship with thrombocytopenia. Thus, this suggests that additional studies are necessary that aim to understand the relationship between reduced haematological parameters in obesity, especially its impact in the development of cardio-metabolic complications.…”

Section: Discussionsupporting

confidence: 77%

Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High-Fat Diet-Fed Mice

et al. 2019

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High-fat diet (HFD) feeding is known to induce metabolic dysregulation, however, less is known on its impact in promoting the hypercoagulable state. This current study aimed to evaluate platelet-monocyte aggregate (PMA) formation following short-term HFD feeding. This is particularly important for understanding the link between inflammation and the hypercoagulable state during the early onset of metabolic dysregulation. To explore such a hypothesis, mice were fed a HFD for 8 weeks, with body weights as well as insulin and blood glucose levels monitored on a weekly basis during this period. Basal hematological measurements were determined and the levels of spontaneous peripheral blood PMAs were assessed using whole blood flow cytometry. The results showed that although there were no significant differences in body weights, mice on HFD displayed impaired glucose tolerance and markedly raised insulin levels. These metabolic abnormalities were accompanied by elevated baseline PMA levels as an indication of hypercoagulation. Importantly, it was evident that baseline levels of monocytes, measured using the CD14 monocyte marker, were significantly decreased in HFD-fed mice when compared to controls. In summary, the current evidence shows that in addition to causing glucose intolerance, such as that identified in a prediabetic state, HFD-feeding can promote undesirable hypercoagulation, the major consequence implicated in the development of cardiovascular complications.

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Section: Discussionsupporting

confidence: 77%

Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High-Fat Diet-Fed Mice

et al. 2019

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“…5,32,33 There was a 5% increase in risk of anemia with each year increase in diabetes duration. This variable is likely to reflect reduced erythropoiesis and enhanced destruction from a variety of effects of chronic hyperglycemia other than nephropathy.…”

Section: Discussionmentioning

confidence: 98%

Anemia complicating type 2 diabetes: Prevalence, risk factors and prognosis

Gauci

Hunter

Bruce

et al. 2017

Journal of Diabetes and its Complications

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“…Women of perimenopausal age (45-55 years old) were also excluded due to potentially increased expression of hepcidin associated with menopause (32, 33). We also excluded patients with severe anemia but included six diabetic subjects with mild to moderate anemia (hemoglobin level in the range of 10-12 g/dL), because it is difficult to avoid involving anemic subjects given the high prevalence of anemia in diabetic patients (34, 35). The expression and localization of Fpn in the enterocytes varied among the individuals in both the diabetic and control groups ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

Banerjee,

Lu,

Jain

et al. 2023

Preprint

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Diabetes is one of the most prevalent chronic diseases worldwide. Iron overload increases the incidence of diabetes and aggravates diabetic complications that cause mortality. Reciprocally, diabetes potentially promotes body iron loading, but the mechanism remains not well understood. In this study, we demonstrated systemic iron excess and the upregulation of iron exporter ferroportin (Fpn) in the enterocytes and macrophages of multiple diabetic mouse models. Increased Fpn expression and iron efflux was also seen in the enterocytes of type 2 diabetic human patients. We further showed that protein kinase C (PKC), which is activated in hyperglycemia, was responsible for the sustained membrane expression of Fpn in physiological and in diabetic settings. For the first time, we identified that PKCs were novel binding proteins and positive regulators of Fpn. Mechanistically, hyperactive PKC promoted exocytotic membrane insertion while inhibited the endocytic trafficking of Fpn in the resting state. PKC also protected Fpn from internalization and degradation by its ligand hepcidin dependent on decreased ubiquitination and increased phosphorylation of Fpn. Importantly, the loss-of-function and pharmacological inhibition of PKC alleviated systemic iron overload in diabetes and hemochromatosis. Our study thus highlights PKC as a novel target in the control of systemic iron homeostasis.

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Genetic disposition and modifiable factors independently associated with anemia in patients with type 2 diabetes mellitus

Cited by 8 publications

References 29 publications

Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High-Fat Diet-Fed Mice

Impaired Glucose Tolerance is Associated with Enhanced Platelet-Monocyte Aggregation in Short-Term High-Fat Diet-Fed Mice

Anemia complicating type 2 diabetes: Prevalence, risk factors and prognosis

Targeting PKC alleviates iron overload in diabetes and hemochromatosis

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