Microalbuminuria in non-diabetic patients with unstable angina/non ST-segment elevation myocardial infarction

Al-Saffar, Hilal B.; Nassir, Hussein; Mitchell, Anna; Philipp, Sebastian

doi:10.1186/s13104-015-1347-x

Cited by 16 publications

(25 citation statements)

References 34 publications

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“…The current study showed that patients with MAU have a greater atherosclerotic burden and a more severe CAD in the form of total number of vessels affected per patient than those without MAU. The results are in accordance with the previously reported findings [ 19 - 22 ]. In the present study, presence of MAU exhibited a significant correlation with the severity of CAD (r = 0.094; P < 0.001).…”

Section: Discussionsupporting

confidence: 94%

Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

et al. 2017

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BackgroundPrevious studies have shown that microalbuminuria (MAU) is an independent risk factor for cardiovascular diseases in diabetics, hypertensive patients and in the general population. However, the correlation of MAU with the severity of coronary artery disease (CAD) in non-diabetic patients has not been addressed in detail. This study aimed to investigate the relationship between MAU and severity of angiographically confirmed CAD in non-diabetic patients.MethodsThis was a cross-sectional study, which included 90 non-diabetic patients with documented CAD by coronary angiography. The ratio of urine albumin to creatinine was used to define MAU and severity of CAD was estimated using SYNTAX score. Patients were divided into two groups: group I that included patients without MAU and group II that included patients with MAU.ResultsOut of 90 non-diabetic CAD patients, 62 (68.9%) were in group I (MAU negative) and 28 (31.1%) were in group II (MAU positive). There was statistically significant difference in the median SYNTAX score between the groups (21 vs. 28, P < 0.001). The prevalences of double vessel CAD and triple vessel CAD were significantly higher in MAU positive group. There was a strong relationship between the presence of MAU and the extent and complexity of CAD (r = 0.094; P < 0.001).ConclusionThus, we conclude that patients with MAU have more severe angiographically detected CAD than those without MAU, and MAU exhibits a significant association with the presence and severity of CAD.

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Section: Discussionsupporting

confidence: 94%

Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

et al. 2017

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“…15 Hilal Bahjet AL-Saffar, Hussein Nassir et al suggested that patients with UA/ NSTEMI found a strong correlation of microalbuminuria with echo-graphic changes and findings in coronary angiography. 16 Male 42 43 85 Female 08 07 15 Total 50 50 100 Table- The result of our study indicates that there is highly significant microalbuminuriain non-diabetic,nonhypertensive AMI patients. The level of significance (P< 0.001) of microalbuminuria in our study, was comparable to that observed, in other international study.…”

Section: Discussionmentioning

confidence: 67%

Study of Microalbuminuria in Non-Diabetic and Non-Hypertensive Patients with Acute Myocardial Infarction

Mustafa¹

2020

IJCMR

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Introduction: Microalbuminuria has relationship on the development of coronary heart disease and it may identify as a new risk factor of this disease. The MA happens more often in diabetic patients with AMI but it has been reported even in non -diabetic patients with AMI. The aim of the present study was to assess the prevalence of microalbuminuria in non diabetic and non hypertensive patients suffering from AMI. To evaluate the relationship between MA and AMI in non-diabetic and non hypertensive patients admitted in ICCU cardiology department at Rajshree Medical Research Institute Bareilly (UP). Matereial and methods:The study was carried out in the department of Biochemistry and ICCU in RMRI, Bareilly (UP) to establish the correlation between MA with 50 non diabetic, non hypertensive patients of AMI and in 50 healthy age matched controls. MA was determined by immunoturbidimetric method and plasma glucose were measured by enzymatic method.Result: There was a significant increase in the level of MA in patients with AMI who were non diabetic, non hypertensive as compare to those in the healthy control.Conclusion: MA may have an association with AMI in absence of traditional risk factors like diabetes and HTN. So MA can be used as an adjunct biochemical parameter in non diabetic, non hypertensive AMI patients.How to cite this article: Asif Mustafa. Study of microalbuminuria in non-diabetic and non-hypertensive patients with acute myocardial infarction.

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“…Zeeshan A, Ahmad Z, Tahir GA, Yaqoob Y in their study on acute coronary syndrome titled MA as atherosclerotic risk factors and its association found MA in 20.4% cases of STEMI. The corresponding figures in NSTEMI and Unstable angina were 21.3% and 25.3% respectively 15 . In contrast, Abdul Ghaffar Memon and Mubashir Kolachi in their study on relationship of MA in non-diabetic and non-hypertensive patients with acute myocardial infarction done in Hyderabad, Pakistan found MA in 53.17% STEMI and15.8% NSTEMI 8 .…”

Section: Discussionmentioning

confidence: 94%

“…ST segment elevation MI cases were not included in their study 14 . Association of microalbuminuria with dyslipidemia and obesity was not significant in our study; however few studies have shown significant association 6,[15][16][17][18] . 98 out of 100 ACS patients in our study were having one or more risk factors.…”

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confidence: 99%

High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease

et al. 2019

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Background and Aims: Patients with Coronary artery disease who undergo percutaneous coronary intervention (PCI) are prescribed with maintenance aspirin dose that vary between 75 mg to 300 mg daily. The objective of this study is to evaluate the effects of high dose versus low dose aspirin doses prescribed on hospital discharge in PCI. Methods: All the patients who had undergone PCI at our hospital from 2017 February to October 2017 were enrolled in the study. They were divided into two groups receiving low dose (<200mg) aspirin and high dose (>200mg) aspirin. Patients were interviewed on phone after completion of one year for the possible complications and new ischemic events during the follow up period. Results: Among 150 patients selected 101 fulfilled the criteria and sixty patients (59.4%) were discharged on low-dose aspirin 75-150mg and 41 patients (40.6%) were discharged on high-dose aspirin of 300mg. The mean age in low aspirin group was 59.8±13.19 years and 49.4±10.7 years in high aspirin group. Although high aspirin dose patients did not complain of epigastric pain more often, upper GI bleeding was significantly higher in high aspirin group 7.5% vs 11.1% (p<0.05). One patient in high aspirin group had hemorrhagic stroke while low aspirin group had none. One patient in high aspirin had sudden cardiac death at home. Clinically, there was no significant difference in new ischemic events during follow up period. Conclusion: In patients with coronary artery disease undergoing PCI, discharge on high-dose rather than low-dose aspirin may increase the rate of bleeding without providing additional ischemic benefit.

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Microalbuminuria in non-diabetic patients with unstable angina/non ST-segment elevation myocardial infarction

Cited by 16 publications

References 34 publications

Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

Study of Microalbuminuria in Non-Diabetic and Non-Hypertensive Patients with Acute Myocardial Infarction

High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease

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