Microalbuminuria: Correlation With Prevalence and Severity of Coronary Artery Disease in Non-Diabetics

Abstract

BackgroundPrevious studies have shown that microalbuminuria (MAU) is an independent risk factor for cardiovascular diseases in diabetics, hypertensive patients and in the general population. However, the correlation of MAU with the severity of coronary artery disease (CAD) in non-diabetic patients has not been addressed in detail. This study aimed to investigate the relationship between MAU and severity of angiographically confirmed CAD in non-diabetic patients.MethodsThis was a cross-sectional study, which included 90 non-diabetic patients with documented CAD by coronary angiography. The ratio of urine albumin to creatinine was used to define MAU and severity of CAD was estimated using SYNTAX score. Patients were divided into two groups: group I that included patients without MAU and group II that included patients with MAU.ResultsOut of 90 non-diabetic CAD patients, 62 (68.9%) were in group I (MAU negative) and 28 (31.1%) were in group II (MAU positive). There was statistically significant difference in the median SYNTAX score between the groups (21 vs. 28, P < 0.001). The prevalences of double vessel CAD and triple vessel CAD were significantly higher in MAU positive group. There was a strong relationship between the presence of MAU and the extent and complexity of CAD (r = 0.094; P < 0.001).ConclusionThus, we conclude that patients with MAU have more severe angiographically detected CAD than those without MAU, and MAU exhibits a significant association with the presence and severity of CAD.

Profile of Non-Diabetic patients with Microalbuminuria in Acute Coronary Syndrome: A hospital based study

“…The overall prevalence of micro-albuminuria in non-diabetic ACS in this study was 73% which was statistically significant (p=0.04). The studies done outside also show similar findings ranging from 58-92% [6][7][8][9][10] . In the study done by F Aziz et al found prevalence of MA to be 56.5% in angiographically proved severe CAD (luminal narrowing > 70%) 11 , Similarly, in the study done by Silva et al on prevalence of MA in 39 patients with angiographically confirmed severe lesion (stenosis > 70%) in at least one coronary artery found to be 33% which was statistically significant 12 .…”

High dose versus low dose Aspirin after Percutaneous Coronary Intervention in Coronary Artery Disease

“…Nepalese Heart Journal retain copyright and works is simultaneously licensed under Creative Commons Attribution License CC -By 4.0 that allows others to share the work with an acknowledge of the work's authorship and initial publication in this journal and the Presence and Extent of Coronary Atherosclerosis" found MA to be an independent predictor for the presence and severity of CAD. They concluded a strong relationship between MA and the severity of CAD 3 . Some studies show patients with higher proteinuria are at risk of developing higher degrees of ACS with adverse outcomes 3,4 .…”

“…They concluded a strong relationship between MA and the severity of CAD 3 . Some studies show patients with higher proteinuria are at risk of developing higher degrees of ACS with adverse outcomes 3,4 .…”

“…For current analysis, aspirin dose less than 200 mg was defined as low dose and more than 200 was defined as high dose. This cutoff point was based on similar previous landmark studies [8][9][10] . All the patients who had undergone PCI at our hospital from 2017 February to October 2017 were enrolled in the study.…”

“…Patients with coronary artery disease who undergo percutaneous coronary intervention (PCI) are prescribed with maintenance aspirin dose that vary between 75 mg to 325 mg daily [1][2][3] . How the aspirin dose affects long term outcome is not clear although few studies have demonstrated low dose to be safer in comparison to high dose [4][5][6] .…”