Micro Two-Dimensional Thin-Layer Chromatography and Chemometric Analysis of Essential Oils from Selected <i>Mentha</i> Species and Its Application in Herbal Fingerprinting

Hawrył, Mirosław; Świeboda, Ryszard; Hawrył, Anna; Niemiec, Małgorzata; Stępak, Klaudia; Waksmundzka‐Hajnos, Monika; Szymczak, Grażyna

doi:10.1080/10826076.2015.1107580

Cited by 9 publications

(3 citation statements)

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“…Such technique is accompanied by a high peak capacity, which is equal to the peak capacity of two individual dimensions, however it requires a long time to reach this maximum capacity. 26,184 Up till now, 2D chromatography has been used with different techniques such as 2D TLC, 185,186 2D GC, 187 and 2D HPLC. 188 The development of 2D chromatographic systems has opened a new perspective in herbal fingerprinting.…”

Section: Two-dimensional Chromatographymentioning

confidence: 99%

“…The analyzed EOs were also assessed for their antioxidant activity. 186 Unfortunately, up to now, not many multidimensional chromatographic techniques that are effective instruments for analyzing complicated herbal extracts have been used. In the future, the integration of diverse 2D chromatographic analyses with biochemometric approaches has the potential to establish a novel approach in natural product drug development.…”

Section: Two-dimensional Chromatographymentioning

confidence: 99%

“…After that, the achieved digital images were processed to determine the similarity between the images, PCA was applied to determine the goodness of matching for individual EOs. The analyzed EOs were also assessed for their antioxidant activity 186 …”

Section: Chromatographic Hyphenated Techniques Used In Biochemometricmentioning

confidence: 99%

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Chemometric‐based drug discovery approaches from natural origins using hyphenated chromatographic techniques

Mahboubifar,

Zidorn,

Farag

et al. 2024

Phytochemical Analysis

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IntroductionIsolation and characterization of bioactive components from complex matrices of marine or terrestrial biological origins are the most challenging issues for natural product chemists. Biochemometric is a new potential scope in natural product analytical science, and it is a methodology to find the compound's correlation to their bioactivity with the help of hyphenated chromatographic techniques and chemometric tools.ObjectivesThe present review aims to evaluate the application of chemometric tools coupled to chromatographic techniques for drug discovery from natural resources.MethodsThe searching keywords “biochemometric,” “chemometric,” “chromatography,” “natural products bioassay,” and “bioassay” were selected to search the published articles between 2010‐2023 using different search engines including “Pubmed”, “Web of Science,” “ScienceDirect,” and “Google scholar.”ResultsAn initial stage in natural product analysis is applying the chromatographic hyphenated techniques in conjunction with biochemometric approaches. Among the applied chromatographic techniques, liquid chromatography (LC) techniques, have taken up more than half (53%) and also, mass spectroscopy (MS)‐based chromatographic techniques such as LC–MS are the most widely used techniques applied in combination with chemometric methods for natural products bioassay. Considering the complexity of dataset achieved from chromatographic hyphenated techniques, chemometric tools have been increasingly employed for phytochemical studies in the context of determining botanicals geographical origin, quality control, and detection of bioactive compounds.ConclusionBiochemometric application is expected to be further improved with advancing in data acquisition methods, new efficient preprocessing, model validation and variable selection methods which would guarantee that the applied model to have good prediction ability in compound relation to its bioactivity.

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