Micro-structured smart hydrogels with enhanced protein loading and release efficiency

Zhang, Jiantao; Petersen, Silvia; Thunga, Mahendra; Leipold, Enrico; Weidisch, Roland; Liu, Xiangli; Fahr, Alfred; Jandt, Klaus D.

doi:10.1016/j.actbio.2009.11.005

Cited by 49 publications

(32 citation statements)

References 44 publications

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“…The BET surface area measurement is crucial for understanding the behavior of a material, as the material reacts with its surroundings via its surface. A higher surface area material is more likely to react faster, dissolve faster and adsorb more gas than a similar material with a lower surface area (Tremaine and Gray, 1976;Zhang et al, 2010;Khan and Bilgainya, 2011). …”

Section: Synthesis and Spectral Characterizationmentioning

confidence: 99%

Synthesis and properties of collagen-g-poly(sodium acrylate-co-2-hydroxyethylacrylate) superabsorbent hydrogels

Sadeghi

Hosseinzadeh

2013

Braz. J. Chem. Eng.

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-Novel biopolymer-based superabsorbent hydrogels were prepared by grafting crosslinked poly(acrylic acid-co-2-hydroxyethyl acrylate) (PAA-co-PHEA) chains onto collagen backbones through a free radical polymerization method. The graft copolymerization reaction was carried out in a homogeneous medium and in the presence of ammonium persulfate (APS) as initiator and N,N ' -methylene bisacrylamide (MBA) as crosslinker. A proposed mechanism for collagen-g-(PAA-co-PHEA) formation was suggested and the hydrogel structure was confirmed using FTIR spectroscopy and TGA thermal analysis. Moreover, the morphology of the samples was examined by scanning electron microscopy (SEM). The effect of concentration of MBA as well as AA/HEA weight ratio on the swelling capacity of the hydrogel was also studied. Furthermore, the water absorbency of hydrogels was measured in solutions with pH ranging 1 to 13. The collagen-based hydrogel exhibited a pH-responsive character, so that a swelling-deswelling pulsatile behavior was recorded at pHs 2 and 8. Preliminary swelling and deswelling behaviors of the hydrogels were also studied. Additionally, the hydrogels exhibited salt-sensitivity and cation exchange properties.

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Section: Synthesis and Spectral Characterizationmentioning

confidence: 99%

Synthesis and properties of collagen-g-poly(sodium acrylate-co-2-hydroxyethylacrylate) superabsorbent hydrogels

Sadeghi

Hosseinzadeh

2013

Braz. J. Chem. Eng.

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“…Then, the hydrogels are taken out from the solvent and the excess of solvent present on their surface is removed by blotting with filter paper. However, this method, that allows to determine the water retained at different temperatures, is unreliable since the gel is taken out at room temperature and tapped for a random time with a filter paper or laboratory tissue [15,16]. Moreover, in the case of microspheres, this method gives wrong results, since it is not possible to discriminate between the water that is present in the microspheres and the water present between the microspheres.…”

Section: Introductionmentioning

confidence: 99%

Lower critical solution temperature versus volume phase transition temperature in thermoresponsive drug delivery systems

Constantin¹,

Cristea²,

Ascenzi³

et al. 2011

Express Polym. Lett.

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Abstract. One of the most subtle problem in the characterization of thermoresponsive polymers is the evaluation of the relationship between the lower critical solution temperature (LCST) of the linear polymer and the volume phase transition temperature (VPTT) of the corresponding hydrogel. Here, the LCST and the onset temperature of linear poly(N-isopropylacrylamide-co-N-hydroxymethyl acrylamide) has been determined under pseudo-physiological conditions by cloud point (CP) measurements and by microcalorimetric analysis. The LCSTs, as well as the onset temperatures, determined by the CP method, decrease with increasing the concentration of the polymer solution. On the contrary, microcalorimetric analyses give almost the same values for LCSTs and the onset temperatures regardless of polymer concentration. The VPTT of the hydrogel, determined by the blue dextran method, was found to be closely similar to the LCST of the concentrated polymer solution (10%, w/v), determined by the CP method. In fact, the hydrogel could be considered as a concentrated polymer solution whose concentration could be related to the amount of water retained by the hydrogel. Hydrogel microspheres have been also reported to release diclofenac, a drug model system, in a pulsating way at temperatures slightly below and above the VPTT.

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“…Previously, we reported the preparation of porous PNIPAAm hydrogels as protein release systems to enhance the loading efficiency of biomacromolecular proteins and to control the release kinetics by tuning the temperature sensitivity [42]. It was found that lysozyme can be easily loaded into and released from both conventional PNIPAAm and porous hydrogels at room temperature.…”

Section: Delivery Applicationsmentioning

confidence: 99%

A novel two-level microstructured poly(N-isopropylacrylamide) hydrogel for controlled release

et al. 2010

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Micro-structured smart hydrogels with enhanced protein loading and release efficiency

Cited by 49 publications

References 44 publications

Synthesis and properties of collagen-g-poly(sodium acrylate-co-2-hydroxyethylacrylate) superabsorbent hydrogels

Synthesis and properties of collagen-g-poly(sodium acrylate-co-2-hydroxyethylacrylate) superabsorbent hydrogels

Lower critical solution temperature versus volume phase transition temperature in thermoresponsive drug delivery systems

A novel two-level microstructured poly(N-isopropylacrylamide) hydrogel for controlled release

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