A novel two-level microstructured poly(N-isopropylacrylamide) hydrogel for controlled release

Zhang, Jiantao; Keller, Thomas F.; Bhat, Rahila; Gari̇pcan, Bora; Jandt, Klaus D.

doi:10.1016/j.actbio.2010.05.009

Cited by 53 publications

(40 citation statements)

References 43 publications

(73 reference statements)

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“…The aminophylline located close to the surface would have been squeezed out together with water molecules during the shrinkage process, upon immersion in PBS at 37°C, as a result of the hydrostatic pressure built up inside the hydrogel [48]. Burst release of drug due to squeezing mechanism has also been reported for novel micro-structured PNIPAAm hydrogels [54] and also for dual-sensitive PNIPAAm copolymer hydrogels [55]. The P(DEAAm-DMAAm) hydrogel with 0.25 wt% crosslinker almost completely released its drug content in about 210 mins, similar to the P(DEAAm-NVP) with same crosslinker content.…”

Section: Drug Loading and Releasementioning

confidence: 94%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

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Novel thermo-sensitive N,N-diethylacrylamide (DEAAm) based copolymer hydrogels were prepared via UV-induced free radical bulk polymerisation. UV polymerisation was employed to avoid the use of potentially toxic solvents; solution polymerisation has been the most common means for the preparation of PDEAAm-based hydrogels in the literature to date. The resultant hydrogels were analysed using nuclear magnetic resonance, Fourier transform infrared spectroscopy and modulated differential scanning calorimetry. Parameters such as the crosslinking degree and the nature of the incorporated hydrophilic component, N-vinyl-2-pyrrolidone (NVP) or N,N-dimethylacrylamide (DMAAm) were found to impact hydrogel structure, mechanical properties and swelling kinetics. Pulsatile swelling studies indicated that the hydrogels had thermo-reversible properties which were greatly affected by test temperature, nature of hydrophilic monomer used and crosslinker content. Aminophylline was selected as a model solute for drug loading and release studies by thermal deswelling in HCl buffer (pH 1.4) and phosphate buffer media (pH 6.8). The observed lag time prior to significant drug release from the more crosslinked P(DEAAm-NVP) hydrogels could make them suitable for delayed specific release in the intestine and potential alternatives to layers or membranes in timespecific and site-specific swelling-controlled drug delivery systems.

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Section: Drug Loading and Releasementioning

confidence: 94%

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

et al. 2012

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“…The common method to enhance the speed of water diffusion is introducing interconnecting pores [12]. Compared with traditional approaches, electrospinning is a facile and effective technique to obtain porous structure.…”

Section: Introductionmentioning

confidence: 99%

Facile fabrication of novel pH-sensitive poly(aspartic acid) hydrogel by crosslinking nanofibers

Zhang

Qin

2014

Materials Letters

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“…Poly(NIPAAm) is one hydrogel that has received much attention because it displays LCST in aqueous medium at around 32 8C. [18,19] Below that temperature the poly(NIPAAm) is soluble, whereas it precipitates out of water as the temperature is raised above its LCST. The important feature is, that the poly(NIPAAm) LCST value bears a tunable character due to the existence of a delicate balance between hydrophilic and hydrophobic groups in its molecular structure.…”

Section: Discussionmentioning

confidence: 99%

In Situ Forming Hydrogels: A Thermo‐Responsive Polyelectrolyte as Promising Liquid Artificial Vitreous Body Replacement

et al. 2011

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The use of fully synthetic polymers as a liquid artificial vitreous body replacement (LAVR) was already considered, but yet none of these polymers have proven to be successful in long term retention in the vitreous cavity due to inadequate biocompatibility and fast biodegradation. Our novel cross‐linked polyelectrolyte as a potential intraocular endotamponade shows an innovative concept of thermoresponsive behavior proposed for the first time in ophthalmologic surgery. The polyelectrolyte has been elaborated via a three‐step procedure by combining classical synthetic protocols and microwave technique. We observed that the polyelectrolyte comprising sodium 2‐acrylamido‐2‐methylpropane sulfonate and acrylic functionalized poly(N‐isopropylacrylamide) macromonomer with glycerol dimethacrylate as cross‐linker displays a noticeable thermosensitive behavior. It exhibits enhancement of shear viscosity at physiological temperatures without phase separation. First in vitro experiments on a retinal ganglion cell line (RGC‐5) present a promising biocompatibility without harmful effects. Cell viability, proliferation rate, and inflammatory cascade (COX‐2 and iNOS expression) were not affected.

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A novel two-level microstructured poly(N-isopropylacrylamide) hydrogel for controlled release

Cited by 53 publications

References 43 publications

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Photopolymerised thermo-responsive poly(N,N-diethylacrylamide)-based copolymer hydrogels for potential drug delivery applications

Facile fabrication of novel pH-sensitive poly(aspartic acid) hydrogel by crosslinking nanofibers

In Situ Forming Hydrogels: A Thermo‐Responsive Polyelectrolyte as Promising Liquid Artificial Vitreous Body Replacement

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