Micro<scp>RNA</scp>‐155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice

Zech, Andreas; Ayata, Cemil Korcan; Pankratz, Franziska; Meyer, Anja; Baudiß, K; Cicko, Sanja; Yegutkin, Gennady G.; Grundmann, Sebastian; Idzko, M.

doi:10.1111/all.12643

Cited by 63 publications

(38 citation statements)

References 36 publications

(64 reference statements)

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“…Similarly, Okoye et al, found that the expression of miR-155 (among other miRNAs) distinguished T H 2 cells from other T cells, and was upregulated in house dust mite-challenged mice (Okoye et al, 2014). miR-155 was specifically required for both T H 2-driven inflammation and activation of dendritic cells (Okoye et al, 2014;Zech et al, 2015), indicating its pathogenic role in allergic asthma.…”

Section: Asthmamentioning

confidence: 90%

The role of microRNAs in chronic respiratory disease: recent insights

Stolzenburg¹,

Harris²

2017

Biological Chemistry

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Chronic respiratory diseases encompass a group of diverse conditions affecting the airways, which all impair lung function over time. They include cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and asthma, which together affect hundreds of millions of people worldwide. MicroRNAs (miRNAs), a class of small non-coding RNAs involved in post-transcriptional gene repression, are now recognized as major regulators in the development and progression of chronic lung disease. Alterations in miRNA abundance occur in lung tissue, inflammatory cells, and freely circulating in blood and are thought to function both as drivers and modifiers of disease. Their importance in lung pathology has prompted the development of miRNA-based therapies and biomarker tools. Here, we review the current literature on miRNA expression and function in chronic respiratory disease and highlight further research that is needed to propel miRNA treatments for lung disorders towards the clinic.

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Section: Asthmamentioning

confidence: 90%

The role of microRNAs in chronic respiratory disease: recent insights

Stolzenburg¹,

Harris²

2017

Biological Chemistry

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“…OVA-treated miR-155 KO mice showed an obvious attenuation of bronchial hyperresponsiveness (BHR), which is one of the dominant features of asthma [49]. Both mucus production and inflammatory cells, in particular, eosinophils induced by OVA asthma, were significantly decreased in the lungs of miR-155 KO mice compared with wild-type mice [45].…”

Section: The Role Of Mir-155 In Asthmamentioning

confidence: 99%

miR-155: A Novel Target in Allergic Asthma

Zhou

Gao

et al. 2016

IJMS

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MicroRNAs (miRNAs), a class of small non-coding RNAs of 18–24 nucleotides in length, function to posttranscriptionally regulate protein expression. miR-155 was one of the first identified and, to date, the most studied miRNA, and has been linked to various cellular processes such as modulation of immune responses and oncogenesis. Previous studies have identified miR-155 as a crucial positive regulator of Th1 immune response in autoimmune diseases, but as a suppressor of Th2 immunity in allergic disorders. However, recent studies have found new evidence that miR-155 plays an indispensible role in allergic asthma. This review summarizes the recent findings with respect to miR-155 in immune responses and the underlying mechanisms responsible for miR-155-related allergic diseases, as well as the similarities between miR-155 and glucocorticoids in immunity.

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“…Mice deficient in miR-155 have been reported to be protected against allergen-induced eosinophilic airway inflammation (17,18). In the present study, an shRNA was applied as a therapeutic strategy to suppress miR-155 expression, which successfully reduced inflammation, infiltration of eosinophils, and the production of the Th2 cytokines IL-4, IL-5 and IL-13.…”

Section: Discussionmentioning

confidence: 84%

“…A deficiency in miR-155 reduces cluster of differentiation (CD)4 + T cell activation and transcription factor expression in the lungs (17). In addition, miR-155 deficient dendritic cells (DCs) have been demonstrated to exhibit limited Th2 priming capacity and thus failed to induce airway inflammation (18). These results indicate that suppression of miR-155 expression, through anti-miR-155 treatment, in CD4 + cells and/or DCs in vivo may contribute to the attenuation of asthmatic features in mouse models of asthma.…”

Section: Discussionmentioning

confidence: 99%

“…In regards to the lungs, mice deficient in miR-155 exhibited enhanced airway remodelling (12) and miR-155 was demonstrated to contribute to the regulation of allergic airway inflammation by modulating Th2 responses through the transcription factor PU.1 (17). In addition, miR-155 deficiency has been identified to alleviate allergic airway inflammation in mice (18). Despite limited evidence linking miR-155 to the etiology of asthma, previous studies have evaluated the feasibility of using miR-155 antagonists to treat asthma (19,20 The present study indicates that miR-155 serves an important proinflammatory role in the development of AHR and allergic airway inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma

Chen

Cheng

et al. 2017

Exp Ther Med

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Abstract. Asthma is a chronic T helper type 2 (Th2) cell-mediated inflammatory disease characterized by airway hyperresponsiveness (AHR) and airway inflammation. Although the majority of patients with asthma can achieve a good level of control with existing treatments, asthma runs a chronic course and the effectiveness of current treatment is not satisfactory for certain patients. MicroRNAs (miRNAs) are short noncoding RNAs that suppress gene expression at the post-transcriptional level; their role in regulating allergic inflammation remains largely unknown. The present study aimed to explore the role of miRNA-155 in the pathogenesis of asthma and its potential as a target for treatment. The expression of miRNA-155 increased in ovalbumin-sensitized and challenged mice compared with control mice, and lentiviral vector-delivered small interfering (si)RNA targeting miRNA-155 resulted in reduced AHR, airway inflammation and Th2 cytokine production. The data from the present study indicate that miRNA-155 serves an important role in the pathogenesis of asthma, and that lentiviral vector-delivered siRNA targeting miRNA-155 may serve as a novel approach for the treatment of allergic asthma.

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MicroRNA‐155 modulates P2R signaling and Th2 priming of dendritic cells during allergic airway inflammation in mice

Abstract: miR-155 deficiency alleviates AAI by diminishing Th2 priming capacity and ATP-/P2R-induced activation of DCs in mice, suggesting this miRNA as a potential therapeutic target of AAI.

Cited by 63 publications

References 36 publications

The role of microRNAs in chronic respiratory disease: recent insights

The role of microRNAs in chronic respiratory disease: recent insights

miR-155: A Novel Target in Allergic Asthma

Small interfering RNA directed against microRNA‑155 delivered by a lentiviral vector attenuates asthmatic features in a mouse model of allergic asthma

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