Micro/nanoscale electrohydrodynamic printing: from 2D to 3D

Zhang, Bing; He, Jiankang; Li, Xiao; Xu, Fangyuan; Li, Dichen

doi:10.1039/c6nr04106j

Cited by 140 publications

(96 citation statements)

References 87 publications

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“…Although many strategies have been developed to control the morphology of electrospinning‐based scaffolds, controlling the morphology at single‐fiber scale remains challenging. Recently, a hybrid system combining 3D printing and electrospinning has been developed, which is referred as electrohydrodynamic printing and can construct a 3D nanofibrous scaffold with a controlled structure at nanoscale (Figure d) (Zhang, He, Li, Xu, & Li, ). The main methods involved in electrohydrodynamic printing include the use of additional devices to improve jet focusing (Lee, Jang, Oh, Jeong, & Cho, ; Lee, Lee, Jang, Jeong, & Cho, ), near‐field electrospinning (Li et al, ), and melt electrospinning (He, Xia, & Li, ; Muerza‐Cascante et al, ).…”

Section: Fabrication Of 3d Nanofibrous Scaffoldsmentioning

confidence: 99%

Three‐dimensional electrospun nanofibrous scaffolds for bone tissue engineering

et al. 2019

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Electrospinning technology has been widely used in the past few decades to prepare nanofibrous scaffolds that mimic extracellular matrices. However, traditional two‐dimensional (2D) electrospun nanofibrous mats still have some inherent disadvantages for bone tissue engineering, such as limited cell infiltration and lack of three‐dimensional (3D) structure. The development of 3D electrospun scaffolds with larger pore sizes and porosity provides new perspectives for electrospinning‐based tissue engineering scaffolds. However, there are still some challenges and areas for improvement. In this review, the applications of 3D electrospun nanofibrous scaffolds in the field of bone tissue engineering from its fabrication methods to bio‐functionalization are summarized, with the aim of providing new insights into the design of electrospinning‐based bone tissue engineering scaffolds.

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Section: Fabrication Of 3d Nanofibrous Scaffoldsmentioning

confidence: 99%

Three‐dimensional electrospun nanofibrous scaffolds for bone tissue engineering

et al. 2019

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“…3D electrohydrodynamic printing, which evolved from electrospinning, is now able to print fibers with diameters from a few micrometers to hundreds of nanometers [101]. With this printing technique, Visser et al built AM-based microfibers as a highly organized architecture to support hydrogel [102] (Figure 4b).…”

Section: Other Am-based Biomimetic Biomedical Constructsmentioning

confidence: 99%

Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations

Zhang

et al. 2016

Materials

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Additive manufacturing (AM), sometimes called three-dimensional (3D) printing, has attracted a lot of research interest and is presenting unprecedented opportunities in biomedical fields, because this technology enables the fabrication of biomedical constructs with great freedom and in high precision. An important strategy in AM of biomedical constructs is to mimic the structural organizations of natural biological organisms. This can be done by directly depositing cells and biomaterials, depositing biomaterial structures before seeding cells, or fabricating molds before casting biomaterials and cells. This review organizes the research advances of AM-based biomimetic biomedical constructs into three major directions: 3D constructs that mimic tubular and branched networks of vasculatures; 3D constructs that contains gradient interfaces between different tissues; and 3D constructs that have different cells positioned to create multicellular systems. Other recent advances are also highlighted, regarding the applications of AM for organs-on-chips, AM-based micro/nanostructures, and functional nanomaterials. Under this theme, multiple aspects of AM including imaging/characterization, material selection, design, and printing techniques are discussed. The outlook at the end of this review points out several possible research directions for the future.

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“…Microextrusion-based cell printing has the drawbacks of low printing resolution as well as the side effect of flow-induced shear stress on cell viability [9][10][11] . Electrohydrodynamic jetting or printing recently attracts extensive attentions in fabricating highresolution features based on the principle of elec tro hydro dy namically induced material flows [12][13][14][15][16][17][18] . Several process parameters had been investigated to achieve stable electrohydrodynamic printing process, such as applied voltage, moving speed, feeding rate of materials and inter diameter of nozzle [19][20][21][22][23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

Coaxial nozzle-assisted electrohydrodynamic printing for microscale 3D cell-laden constructs

Liang¹,

He²,

Chang³

et al. 2017

ijb

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Cell printing has found wide applications in biomedical fields due to its unique capability in fabricating living tissue constructs with precise control over cell arrangements. However, it is still challenging to print cell-laden 3D structures simultaneously with high resolution and high cell viability. Here a coaxial nozzle-assisted electrohydrodynamic cell printing strategy was developed to fabricate living 3D cell-laden constructs. Critical process parameters such as feeding rate and stage moving speed were evaluated to achieve smaller hydrogel filaments. The effect of CaCl 2 feeding rate on the printing of 3D alginate hydrogel constructs was also investigated. The results indicated that the presented strategy can print 3D hydrogel structures with relatively uniform filament dimension (about 80 μm) and cell distribution. The viability of the encapsulated cells was over 90%. We envision that the coaxial nozzle-assisted electrohydrodynamic printing will become a promising cell printing strategy to advance biomedical innovations. Keywords: electrohydrodynamic printing; cell printing; bioprinting; biofabrication; tissue engineering

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Micro/nanoscale electrohydrodynamic printing: from 2D to 3D

Cited by 140 publications

References 87 publications

Three‐dimensional electrospun nanofibrous scaffolds for bone tissue engineering

Three‐dimensional electrospun nanofibrous scaffolds for bone tissue engineering

Additive Manufacturing of Biomedical Constructs with Biomimetic Structural Organizations

Coaxial nozzle-assisted electrohydrodynamic printing for microscale 3D cell-laden constructs

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