Micro-homogeneity of Candidate Reference Materials Characterized by Particle Size and Homogeneity Factor Determination

Sonntag, T.-M.; Roßbach, M.

doi:10.1039/a605396c

Cited by 24 publications

(8 citation statements)

References 13 publications

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“…The material, after spray drying, proved to be extremely fine grained with a mean particle size around 3.5 µm with a narrow range of 95% from 2 to 12 µm ( Fig. 1) [5,10,11,12].…”

Section: Methodsmentioning

confidence: 98%

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Assessment of element-specific homogeneity in reference materials using microanalytical techniques

Roßbach

Zeiller

2003

Analytical and Bioanalytical Chemistry

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The IAEA established in 1994 a co-ordinated research programme (CRP) on "Reference Materials for Microanalytical Nuclear Techniques" as part of its efforts to promote and strengthen the use of nuclear analytical technologies in member states with the specific aim of improving the quality of analysis of nuclear, environmental, and biological materials. The objectives of this initiative were: to identify suitable biological reference materials which could serve the needs for quality control in microanalytical techniques; to evaluate existing CRMs for use in microanalytical investigations; to evaluate appropriate sample pretreatment procedures for materials being used for analysis with microanalytical techniques; to identify analytical techniques which can be used for characterisation of homogeneity determination, and to apply such techniques to the characterization of candidate reference materials for use with microanalytical techniques. The CRP lasted for 4 years and seven laboratories and the Agency's Laboratories in Seibersdorf participated. A number of materials including the candidate reference materials IAEA 338 (lichen) and IAEA 413 (single cell algae, elevated level) were evaluated for the distribution of elements such as Cl, K, Ca, Cr, Mn, Fe, Zn, As, Br, Rb, Cd, Hg, and Pb. The results obtained during this CRP suggest that: each element exhibits its characteristic distribution in a matrix described by the "Ingamels' sampling constant" or the "relative homogeneity factor" of Kurfuerst; both concepts are valid over a large range of sample mass used for analysis (from 0.1 microg to around 100 mg); and materials being characterised quantitatively for element homogeneity could be used for the experimental determination of total uncertainty of other analytical techniques. As far as we are aware this is the first time the concept of quantitative characterisation of homogeneity has been applied to potential reference materials and the first demonstration of the feasibility and usefulness of the concept with particular emphasis on enhancing quality control opportunities for microanalytical techniques.

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“…The material, after spray drying, proved to be extremely fine grained with a mean particle size around 3.5 µm with a narrow range of 95% from 2 to 12 µm ( Fig. 1) [5,10,11,12].…”

Section: Methodsmentioning

confidence: 98%

“…The theory of analyte distribution in materials is well described in textbooks [1,2] and an increasing number of scientific publications [3,4,5,6,7,8]. The accurate determination of sampling constants (Ingamels), relative homogeneity factors (Kurfuerst), or minimum sample mass (Pauwels) is achievable by application of direct methods…”

Section: Introductionmentioning

confidence: 99%

Assessment of element-specific homogeneity in reference materials using microanalytical techniques

Roßbach

Zeiller

2003

Analytical and Bioanalytical Chemistry

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“…Examples are: Pb, Cd, Hg, Zn, and Fe in codfish candidate RM, Hg in copper metal, Zn in mussel tissue, Cd, Pb, Hg, Fe, and Zn in cod muscle, Cd in plastic CRMs, and Cu, Cd, and Pb in various IAEA CRMs (Pauwels et al , 1994Sonntag and Rossbach 1997). Examples are: Pb, Cd, Hg, Zn, and Fe in codfish candidate RM, Hg in copper metal, Zn in mussel tissue, Cd, Pb, Hg, Fe, and Zn in cod muscle, Cd in plastic CRMs, and Cu, Cd, and Pb in various IAEA CRMs (Pauwels et al , 1994Sonntag and Rossbach 1997).…”

Section: Control Of Materials Propertiesmentioning

confidence: 99%

From Planning to Production

Stoeppler¹

2000

References Materials for Chemical Analysis

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“…In order to obtain an estimate of the minimum sample intake amount, assays were performed to determine the relative homogeneity factor, or Kurfurst constant, (H E ), a parameter used for this purpose by several authors [3][4][5]. To quantify the homogeneity of an element in a given matrix, Kurfurst [3] defined a relative homogeneity factor (H E ) based on a modification of the Ingamells sampling constant [6].…”

Section: Introductionmentioning

confidence: 99%

Micro-homogeneity evaluation of a bovine kidney candidate reference material

Castro

2019

Braz. J. Rad. Sci.

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The minimum sample intake for which a reference material remains homogeneous is one of the parameters that must be estimated in the homogeneity assessment study of reference materials. In this work, Instrumental Neutron Activation Analysis was used to evaluate this quantity in a bovine kidney candidate reference material. The mass fractions of 9 inorganic constituents were determined in subsamples between 1 and 2 mg in order to estimate the relative homogeneity factor (HE) and the minimum sample mass to achieve 5% and 10% precision on a 95% confidence level. Results obtained for HE in all the analyzed elements were satisfactory. The estimated minimum sample intake was between 2 mg and 40 mg, depending on the element.

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Micro-homogeneity of Candidate Reference Materials Characterized by Particle Size and Homogeneity Factor Determination

Cited by 24 publications

References 13 publications

Assessment of element-specific homogeneity in reference materials using microanalytical techniques

Assessment of element-specific homogeneity in reference materials using microanalytical techniques

From Planning to Production

Micro-homogeneity evaluation of a bovine kidney candidate reference material

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