Micro-Encapsulation of Antibiotic in Cellulose Nanoparticle Inhibits Bacteria

Gopinath, Subash C.B.; Goh, Chong S.; Citartan, Marimuthu; Lakshmipriya, Thangavel; Arshad, M.K. Md; Faudzi, Fatin Nabilah Mohd; Ruslinda, A. Rahim; Hashim, Uda; Chinni, Suresh V.; Tang, Thean‐Hock

doi:10.2174/1876402908666160720104019

Cited by 3 publications

(4 citation statements)

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“…Similar to the above case with the silver nanoparticle, another nanostructure cellulose nanoparticle was also demonstrated for carrying the biological ligands. In this case, cow urine was collected and encapsulated in the cellulose nanoparticle by microemulsion method as stated earlier [16]. The cow urine encapsulated cellulose nanoparticle was observed under FESEM as displayed in the Figure 8.…”

Section: Cellulose Nanoparticle As the Carrier For Biological Ligandsmentioning

confidence: 98%

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Engineered nanostructures to carry the biological ligands

Gopinath

Ramanathan

Suk

et al. 2018

MATEC Web of Conferences

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Different nanostructures were engineered with the nanoscale dimension lesser than 100 nm. These nanostructures include silver, cellulose nanoparticles and single-walled carbon nanotube (SWCNT). Biological ligands were obtained from the medicinally important herbal plants, such as Solanum trilobatum and Hempedu bumi and conjugated with the nanostructures silver nanoparticle and SWCNT, respectively. On the other hand, bio-ligands from cow urine were encapsulated in the cellulose nanoparticle. To confirm morphology these nanostructures, they were observed under Field Emission Scanning Electron Microscope and the results displayed the uniformed nanostructures. Further, biological ligand carrying ability of these nanostructures was confirmed by the bacterial inhibition assay on the agar plate. This study provided the evidence on the capability of nanostructures to carry the biological ligands.

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Section: Cellulose Nanoparticle As the Carrier For Biological Ligandsmentioning

confidence: 98%

“…The obtained pellet was washed with double distilled water twice. For the encapsulation of cow urine, the previous method proposed was followed as outlined [16]. SWCNTs were purchased commercially and conjugated electrostatically with the extract prepared from Hempedu bumi.…”

Section: Preparation Of Nanostructuresmentioning

confidence: 99%

Engineered nanostructures to carry the biological ligands

Gopinath

Ramanathan

Suk

et al. 2018

MATEC Web of Conferences

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“…In this regard, the improvement of the bactericidal effect achieved by different encapsulation methods in antimicrobials such as ampicillin [26], or clofazimine [27] is noteworthy. Among these, encapsulation using cationic and anionic liposomes is of interest; this method has succeeded in improving some aspects related to the high rate of drug degradation and certain side effects [28].…”

Section: Introductionmentioning

confidence: 99%

Use of Nanoparticles to Prevent Resistance to Antibiotics—Synthesis and Characterization of Gold Nanosystems Based on Tetracycline

et al. 2022

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Antimicrobial resistance (AMR) is a serious public health problem worldwide which, according to the World Health Organization (WHO), requires research into new and more effective drugs. In this work, both gold nanoparticles covered with 16-3-16 cationic gemini surfactant (Au@16-3-16) and DNA/tetracycline (DNA/TC) intercalated complexes were prepared to effectively transport tetracycline (TC). Synthesis of the Au@16-3-16 precursor was carried out by using trihydrated gold, adding sodium borohydride as a reducing agent and the gemini surfactant 16-3-16 as stabilizing agent. Circular dichroism and atomic force microscopy techniques were then used to ascertain the optimal R range of the relationship between the concentrations of Au@16-3-16 and the DNA/TC complex (R = CAu@16-3-16/CDNA) that allow the obtainment of stable and compact nanosystems, these characteristics being fundamental for their use as antibiotic transporters. Stability studies over time were carried out for distinct selected Au@16-3-16 and Au@16-3-16/DNA-TC nanoformulations using the ultraviolet–visible spectrophotometry technique, checking their stability for at least one month. In addition, in order to know the charge and size distribution of the nanocomplexes, DLS and zeta potential measurements were performed in the solution. The results showed that the characterized nanosystems were highly charged, stable and of a reduced size (<100 nm) that allows them to cross bacterial membranes effectively (>1 μm). Once the different physicochemical characteristics of the gold nanosystems were measured, Au@16-3-16 and Au@16-3-16/DNA-TC were tested on Escherichia coli and Staphylococcus aureus to study their antibacterial properties and internalization capacity in microbes. Differences in the interaction of the precursors and the compacted nanosystems generated were observed in Gram-positive and Gram-negative bacteria, possibly due to membrane damage or electrostatic interaction with internalization by endocytosis. In the internalization experiments, depending on the treatment application time, the greatest bacterial destruction was observed for all nanoformulations explored at 18 h of incubation. Importantly, the results obtained demonstrate that both new nanosystems based on TC and Au@16-3-16 precursors have optimal antimicrobial properties and would be beneficial for use in patients, avoiding possible side effects.

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“…As a natural polymer, cellulose is renewable, eco-friendly, inexpensive, non-toxic, biodegradable, and biocompatible (Olivera et al 2016;Gunny et al 2021). It is an organic carbohydrate component, composed of repeating β-D-glucopyranose units that have three hydroxyl groups per anhydroglucose unit, yielding a high degree of functionality for cellulose molecules (Kusumattaqiin and Chonkaew 2015;Gopinath et al 2016;Yuen et al 2019). As shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Generation of microcrystalline cellulose from cotton waste and its properties

Tan

Gopinath

Anbu

et al. 2023

BioRes

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Microcrystalline cellulose (MCC) is a green material that has widespread applications in pharmaceuticals, food, cosmetics, and other industries because of its biocompatibility, biodegradability, hydrophilicity, and acid-insolubility. In this study, MCC was prepared from cotton waste via alkaline treatment and sulfuric acid hydrolysis. Further, the synthesized cotton-based MCC was characterized using Fourier transform infrared (FTIR), X-ray photoelectron, and energy dispersive X-ray spectroscopies. Based on these results, the major components were identified as carbon and oxygen. This finding was evidenced by the FTIR analysis, which displayed peak wavenumbers at 3446.9, 2891.1, 1649.5, 1380.1, 1061.2, and 1050 to 1150 cm-1. The surface morphology was also examined by field emission scanning electron microscopy and field emission transmission electron microscopy, which showed that the prepared MCC has a smooth surface and a consistent, rod-like shape. In addition, the MCC exhibited the typical diffraction peaks of a crystalline structure of cellulose II at 12.2°, 20°, and 22.03°, which correspond to the diffraction planes of 1-10, 110, and 020, respectively, and had a crystallinity index of 78.7%. Moreover, the prepared MCC had a diameter of 37.8 µm and exhibited good stability with a peak at -76.5 mV. Further, the cotton-based MCC exhibited high thermal stability, as revealed by the TGA.

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Micro-Encapsulation of Antibiotic in Cellulose Nanoparticle Inhibits Bacteria

Cited by 3 publications

References 0 publications

Engineered nanostructures to carry the biological ligands

Engineered nanostructures to carry the biological ligands

Use of Nanoparticles to Prevent Resistance to Antibiotics—Synthesis and Characterization of Gold Nanosystems Based on Tetracycline

Generation of microcrystalline cellulose from cotton waste and its properties

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