2022
DOI: 10.3390/pharmaceutics14091941
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Use of Nanoparticles to Prevent Resistance to Antibiotics—Synthesis and Characterization of Gold Nanosystems Based on Tetracycline

Abstract: Antimicrobial resistance (AMR) is a serious public health problem worldwide which, according to the World Health Organization (WHO), requires research into new and more effective drugs. In this work, both gold nanoparticles covered with 16-3-16 cationic gemini surfactant (Au@16-3-16) and DNA/tetracycline (DNA/TC) intercalated complexes were prepared to effectively transport tetracycline (TC). Synthesis of the Au@16-3-16 precursor was carried out by using trihydrated gold, adding sodium borohydride as a reducin… Show more

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Cited by 4 publications
(14 citation statements)
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“…It is important to note that the NS 2 preparation has the same AMOX concentration as the control in Figure 13B; thus, the results obtained here support the benefit of using Au@16-mph-16 nanoparticles as nanocarriers for antibacterial drugs. Being a Gram-positive bacterium, the destabilization mechanisms of the biosynthetic machinery via the induction of the release of free oxygen radicals are similar to those previously described for S. aureus [21,[70][71][72][73][74][75][76][77]. However, these bacteria are not reactive to catalase, while S. aureus are positive.…”
Section: Results Of Gold Nanosystems' Susceptibility Tests Against Gr...supporting
confidence: 65%
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“…It is important to note that the NS 2 preparation has the same AMOX concentration as the control in Figure 13B; thus, the results obtained here support the benefit of using Au@16-mph-16 nanoparticles as nanocarriers for antibacterial drugs. Being a Gram-positive bacterium, the destabilization mechanisms of the biosynthetic machinery via the induction of the release of free oxygen radicals are similar to those previously described for S. aureus [21,[70][71][72][73][74][75][76][77]. However, these bacteria are not reactive to catalase, while S. aureus are positive.…”
Section: Results Of Gold Nanosystems' Susceptibility Tests Against Gr...supporting
confidence: 65%
“…In Figure 12E,F, we can see the effect of the treatment with the nanosystem. Since the NS 2 charge is negative, the mechanism of action is driven by an electrostatic interaction, contributing to internalization by endocytosis, releasing the antibiotic from the precursor and causing a mismatch in metabolic signal transduction similar to that described above, thereby destroying the biosynthetic machinery of the microorganism and causing its death [21,[70][71][72][73][74][75][76][77]. Finally, in Figure 13, we can see the result of the treatments carried out on S. pneumoniae, which is a lactic acid, facultative anaerobic, catalase-negative bacterium.…”
Section: Results Of Gold Nanosystems' Susceptibility Tests Against Gr...mentioning
confidence: 99%
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