Micro and nanoparticle deposition in human nasal passage pre and post virtual maxillary sinus endoscopic surgery

Numerical simulation of airflow and micro-particle deposition in human nasal airway pre- and post-virtual sphenoidotomy surgery

“…This is because most of the larger particles deposit in the anterior parts of the nasal cavity, and only a small fraction reaches the sinus. Abouali et al [2] reported a similar trend of variation with particle size for the deposition fraction in the maxillary sinus.…”

“…In addition, the virtual surgery would allow for testing various alternatives and for optimal surgical planning [2]. Recently, due to the rapid growth in computer technology, researchers have been able to prepare accurate 3-D computational models from CT scan images.…”

“…Rennie et al investigated sinus ventilation experimentally and numerically for single-and double-ostium sinuses [29]. Abouali et al [2] constructed realistic 3-D computational models of the human nasal passage for pre-and post-virtual uncinectomy and Middle Meatal Antrostomy (MMA). They showed that after maxillary sinus endoscopic surgery, the maxillary sinus ventilation changes dramatically and the deposition of inhaled nano/micro-particles in the sinus increases.…”

Patient specific CFD models of nasal airflow: Overview of methods and challenges

“…Quite recently, Abouali et al (2012) developed realistic 3D models of the human nasal airway for pre-and post-virtual uncinectomy and MMA and showed that after maxillary sinus endoscopic surgery, the inhaled nano-and micro-particles can easily enter the sinus due to penetration of the airflow into the sinus cavity. Although those computational studies successfully demonstrated that aggressive sinus surgery can significantly change the intranasal flow behavior, they did not pay much attention to the effect of surgical intervention on the ventilation characteristics.…”

Detailed micro-particle deposition patterns in the human nasal cavity influenced by the breathing zone

“…Since then computational studies have investigated its anatomical form, airflow patterns, and fluid-particle interactions to gain a better understanding of: respiration function [7][8][9][10]; airconditioning [11,12]; and surgical implications [13][14][15][16][17]. When a secondary particle phase is introduced, inhaled particles coupled to the airflow field, allow studies of nasal drug delivery [18][19][20][21][22]; and inhalation toxicology [23][24][25] or general particle deposition studies [26,27].…”