Statement of the problem:The 2 step ceramic surface treatment " HF acid etching followed by silane application" has been used for years to secure an efficient bond between ceramics and resin cements, however the urge for simplification and making the bonding procedure less technique sensitive have pushed the dentists to shift to one step ceramic surface treatment "self etch ceramic primer". Although studies proved their reliability, till now there is no data available on their effect on bond stability in different pH conditions Purpose: The aim of the current study was to evaluate microshear bond strength between resin and different ceramic materials (e.max, VITA ENAMIC and VITA SUPPRINITY) preatreated with two different protocols (2 step and 1 step) after being subjected to various pH storage media Materials and Methods: A total of ninety ceramic discs were fabricated in this study from CAD/ CAM blocks. The discs were divided into three groups according to ceramic material as follows; Group 1: Thirty discs constructed from lithium disilicate glass ceramic (e.max CAD), Group 2: Thirty discs constructed from polymer infiltrated ceramic-network material (VITA ENAMIC) and Group 3: Thirty discs constructed from Zirconia-lithium silicate glass-ceramic materials (VITA SUPRINITY). Each of the previous groups were further subdivided into two equal subgroups according to the surface treatment protocol used as follows; Subgroup 1: fifteen discs were treated with 2 step bonding protocol (etched with hydrofluoric acid followed by silane application) and Subgroup 2: fifteen discs were treated with 1 step application of self etching primer (Monobond etch and prime). The two subgroups were again equally divided (5 each) and assigned to one of the three storage solutions with different pHs : acidic, neutral and alkaline media.Ceramic discs were obtained by sectioning the CAD/CAM blocks using Isomat 1000 followed by crystallization of the e.max and VITA SUPPRINITY discs. For first subgroup, the ceramic discs were subjected to two step surface treatment protocol consisting of hydroflouric acid etching, rinsing followed by silane application. While the second subgroup was subjected to surface treament using one (668)