Micro- and Nano-Carrier Mediated Intra-Articular Drug Delivery Systems for the Treatment of Osteoarthritis

Zhang, Zhiyue; Huang, Guihua

doi:10.1155/2012/748909

Cited by 45 publications

(33 citation statements)

References 81 publications

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“…Arthritis refers to various medical conditions associated with joint disorders of the primary structures, such as the synovial membranes, bones, and cartilage. Among the different types of arthritis, such as osteoarthritis (OA), rheumatoid arthritis (RA), ankylosing spondylitis, septic arthritis, and juvenile idiopathic arthritis, OA and RA are the most common worldwide, affecting 40 million people in the USA in 1995, with expectations that this number will reach 59.4 million people by 2020 (1,2). OA is a disease of the cartilage characterized by progressive deterioration as the structure loses the natural ability to repair itself.…”

Section: Introductionmentioning

confidence: 99%

“…Because such inflammatory arthritic diseases are localized, intra-articular delivery may be a suitable alternative by compartmentally targeting drugs into arthritic joints, and are widely used by patients suffering inflammatory arthritic diseases (6)(7)(8)(9)(10). The most important advantage of intra-articular treatment of arthritis is targeting the drug to the specific inflammatory site and minimizing its systemic toxic effects (2). However, current preparations of intraarticular drug therapies often require frequent injections that rapidly degrade and clear injected pharmacologic agents, impacting on finances and the patient's quality of life, as well as increasing the risk of complications.…”

Section: Introductionmentioning

confidence: 99%

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Formulation and Optimization of Nonionic Surfactants Emulsified Nimesulide-Loaded PLGA-Based Nanoparticles by Design of Experiments

et al. 2013

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This investigation aimed to develop nimesulide (NMS)-loaded poly(lactic-co-glycolic acid) (PLGA)-based nanoparticulate formulations as a biodegradable polymeric drug carrier to treat rheumatoid arthritis. Polymeric nanoparticles (NPs) were prepared with two different nonionic surfactants, vitamin E d-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS) and poly(vinyl alcohol) (PVA), using an ultrasonication solvent evaporation technique. Nine batches were formulated for each surfactant using a 3(2) factorial design for optimal concentration of the emulsifying agents, 0.03-0.09% for vitamin E TPGS and 2-4% for PVA. The surfactant percentage and the drug/polymer ratio (1:10, 1:15, 1:20) of the NMS-loaded NPs were investigated based on four responses: encapsulation efficiency, particle size, the polydispersity index, and the surface charge. The response surface plots and linearity curves indicated a relationship between the experiment's responses and a set of independent variables. The NPs produced with both surfactants exhibited a negative surface charge, and scanning electron micrographs revealed that all of the NPs were spherical in shape. A narrower size distribution and higher drug loadings were achieved in PVA-emulsified PLGA NPs than in the vitamin E TPGS emulsified. Decreasing amounts of both nonionic surfactants resulted in a reduction in the emulsion's viscosity, which led to a decrease in the particle size of NPs. According to the ANOVA results obtained in this present research, vitamin E TPGS exhibited the best correlation between the independent variables, namely drug/polymer ratio and the surfactant percentage, and the dependent variables (encapsulation efficiency R(2) = 0.9603, particle size R(2) = 0.9965, size distribution R(2) = 0.9899, and surface charge R(2) = 0.8969) compared with PVA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Nonionic Surfactants Emulsified Nimesulide-Loaded PLGA-Based Nanoparticles by Design of Experiments

et al. 2013

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“…The US Food and Drug Administration (FDA) has approved the use of intra-articular hyaluronic acid formulations for osteoarthritis of the knee, thereby minimizing the side effects. However, this preparation often requires frequent injections which carry a high financial burden and reduces patient compliance (1). Therefore, there is a need for an alternative drug administration route which will increase patient compliance.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, an inflammation-sensitive drug delivery system would provide more benefits to the arthritic patients by having the propensity to penetrate the skin and release the incorporated anti-inflammatory drug at the site/s of inflammation. These systems could lengthen drug retention times, decrease the clearance of drug into joint cavities, enhance the therapeutic effect of pharmaceutical agents, and increase patient compliance (1).…”

Section: Introductionmentioning

confidence: 99%

Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

et al. 2015

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Abstract. The most successful treatment strategy for arthritis is intra-articular injections that are costly and have reduced patient compliance. The purpose of the current study was to develop an inflammationsensitive system for topical drug administration. Multi-macromolecular alginate-hyaluronic acid-chitosan (A-H-C) polyelectrolyte complex nanoparticles, loaded with indomethacin were developed employing pre-gel and post-gel techniques in the presence of dodecyl-L-pyroglutamate (DLP). In addition to in vitro studies, in silico simulations were performed to affirm and associate the molecular interactions inherent to the formulation of core all-natural multi-component biopolymeric architectures composed of an anionic (alginate), a cationic (chitosan), and an amphi-ionic polyelectrolytic (hyaluronic acid) macromolecule. The results demonstrated that DLP significantly influenced the size of the synthesized nanoparticles. Drug-content analysis revealed higher encapsulation efficiency (77.3%) in the presence of DLP, irrespective of the techniques used. Moreover, in vitro drug release studies showed that indomethacin release from the nanosystem was significantly improved (98%) in Fenton's reagent. Drug permeation across a cellulose membrane using a Franz diffusion cell system showed an initial surge flux (0.125 mg/cm −2 /h), followed by sustained release of indomethacin for the post-gel nanoparticles revealing its effective skin permeation efficiency. In conclusion, the study presents novel nanoparticles which could effectively encapsulate and deliver hydrophobic drugs to the target site, particularly for arthritis.

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“…Previous studies have indicated that intra-articular administration of gelatin microspheres does not induce any inflammatory reaction [19] . Recently, special attention has been focused on the preparation of gelatin microspheres containing NSAIDs for intraarticular administration [6,20,21] .…”

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confidence: 99%

Biodegradable Gelatin Microspheres as Controlled Release Intraarticular Delivery System: The Effect of Formulation Variables

Farhangi¹

2017

ijps

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Farhangi, et al.: Gelatin Microspheres for Intraarticular DeliveryIntraarticular administration of microspheres containing non-steroidal antiinflammatory drugs is beneficial in the treatment of rheumatoid arthritis. Microspheres could localize drug at the site of administration and control its release, resulting in improved therapeutic effects and decreased side effects. Therefore, the objective of the present study was to prepare controlled release meloxicam-loaded gelatin microspheres and evaluate the effect of various variables on their properties. Meloxicam-loaded microspheres were prepared by emulsion-congealing-chemical cross-linking method. Different amounts of polymer, emulsifier and crosslinking agent, as formulation variables, were evaluated. Microspheres were characterized in terms of yield value, encapsulation efficiency and the drug release pattern. The particle size, surface morphology and thermal behaviour of microspheres were also investigated. According to the results, using glutaraldehyde as a cross-linking agent resulted in spherical microspheres with the yield value of 63-96% and encapsulation efficiency of 23-63%. The optimum formulation with the mean particle size of about 57 μm, showed slow drug release profile (64%) throughout 48 h. An appropriate polymer:cross-linker ratio must be used to obtain suitable particles with acceptable controlled released behaviour. In summary the results of the present study supported the preparation of sustained release meloxicam-loaded microspheres using emulsion-congealing method along with the potential application of glutaraldehyde in improving the physical properties of prepared particles as well as the release profile of this low water soluble drug.

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Micro- and Nano-Carrier Mediated Intra-Articular Drug Delivery Systems for the Treatment of Osteoarthritis

Cited by 45 publications

References 81 publications

Formulation and Optimization of Nonionic Surfactants Emulsified Nimesulide-Loaded PLGA-Based Nanoparticles by Design of Experiments

Formulation and Optimization of Nonionic Surfactants Emulsified Nimesulide-Loaded PLGA-Based Nanoparticles by Design of Experiments

Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

Biodegradable Gelatin Microspheres as Controlled Release Intraarticular Delivery System: The Effect of Formulation Variables

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