Micro-anatomical changes in major blood vessel caused by dengue virus (serotype 2) infection

Priya, Sivan Padma; Sakinah, Siti; Ling, Mok Pooi; Chee, Hui Yee; Higuchi, Akon; Hamat, Rukman Awang; Neela, Vasantha Kumari; Alarfaj, Abdullah A.; Munusamy, Murugan A.; Hatamleh, Ashraf Atef; Al-Sabri, Ahmed; Al-Suwailem, Ibrahim Ahmad Abdulaziz; Rajan, Mariappan; Benelli, Giovanni; Marlina, Marlina; Kumar, S. Suresh

doi:10.1016/j.actatropica.2017.04.010

Cited by 5 publications

(7 citation statements)

References 47 publications

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“…Several studies have been carried out using mice as a model for DENV infection. The mice susceptibility to various serotypes of DENV was demonstrated, including DENV-2 [8][9][10][11][12][13][14][15]. In this study, BALB/c mice did not show physical alteration or mortality after repeated infections with DENV-2, except for ruffled fur.…”

Section: Discussionmentioning

confidence: 59%

“…Both of them are characterized by hemorrhages and shock syndrome [21]. DENV-2 infection raises the virus production within the body and affects most of the internal organs, as recently pointed out by researches conducted on liver tissues and blood cells from experimentally infected mice populations [9,10]. With its well know characteristics, DENV increases the permeability of endothelium bed of the vessel and leads to the fluid extravasations from the endothelium bed into the body cavity.…”

Section: Discussionmentioning

confidence: 99%

“…Another study histopathological CONTACT S. Suresh Kumar sureshkudsc@gmail.com The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, Pisa 56025, Italy study by Sakinah et al, 2017, showed extensive damage to the liver of BALC/c mice after dengue infections including loss of cell integrity, increase cells infiltrations, cytopathic effects, necrosis and apoptosis of liver cells. While study by Priya et al, 2017, exhibited histological changes in major blood vessels after DENV infection. These findings prove that the tissue morphological changes are like human DF and DHF, showing BALB/c are tolerant host for DENV-2 replication [8][9][10][11][12][13][14][15].…”

Section: Introductionmentioning

confidence: 94%

“…While study by Priya et al, 2017, exhibited histological changes in major blood vessels after DENV infection. These findings prove that the tissue morphological changes are like human DF and DHF, showing BALB/c are tolerant host for DENV-2 replication [8][9][10][11][12][13][14][15]. Overall, the above discussed studies have been scarcely considered and the potential impact of DENV on lung tissues still deserves major research attention [16].…”

Section: Introductionmentioning

confidence: 94%

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Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences

Sakinah

Kumari

Munisvaradass

et al. 2018

Pathogens and Global Health

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To determine the effect of DENV (serotype 2) repeated infections on lung cells is the main goal of this study. From the result, lung histology of control BALB/c mice showed normal alveolar morphology, while vehicle control BALB/c mice highlighted a slight thickening of the alveolar septum. Lung histopathology of BALB/c mice infected twice by DENV-2 showed the presence of hemorrhage, plasma leakage and presence of hemosiderin-laden macrophages (HLMs). Notably, in the lung of BALB/c mice infected four times by DENV-2, we observed thickening and disruption of the alveolar septum, inflammatory cell infiltration, plasma leakage and increased cellularity. Megakaryocyte releasing platelets were also found into the lung alveolus. Overall, our findings showed severe histopathological damage in lungs repeatedly infected by DENV-2, allowing us to argue that they can be linked to pulmonary complication. Result also showed that the number of infections with similar total DENV-2 titer led to different histopathological changes.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 94%

See 2 more Smart Citations

Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences

Sakinah

Kumari

Munisvaradass

et al. 2018

Pathogens and Global Health

Self Cite

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“…This is known as dengue hemorrhagic fever/dengue shock syndrome with cytokine storm. [4][5][6] Previous studies demonstrate that antibody-dependent enhancement (ADE) plays an important role in disease aggravation. 7 The formation of immune complexes that interact with fragment crystallizable γ receptors cause serotypespecific, subneutralizing, weak antibodies resulting from primary DV infection to stimulate different serotype DV-infected cells to facilitate secondary infection.…”

mentioning

confidence: 99%

Secondary cross infection with dengue virus serotype 2/3 aggravates vascular leakage in BALB/c mice

Qiu

Huang

Luo

et al. 2022

Journal of Medical Virology

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Dengue virus (DV) has occasionally emerged at epidemic levels in Yunnan, China. Vaccine development is limited by antibody-dependent enhancement and a lack of good animal models. Thus, the study investigated cross infection based on maternal immunity in BALB/c mice and assessed the risk of cross infection by DV2-D13113 and DV3-YNWS2 epidemic virus strains. DV replicated within the organs of the BALB/c infant mice, even causing death. Particularly, DV3-infected infant mice were at higher risk of severe disease if their mothers were infected with DV2. Although BALB/c adults and pups survived DV2/DV3 infection and produced anti-DV antibodies after 5-8 days, extensive subcutaneous vascular leakage was observed after secondary DV infection. Furthermore, vascular permeability in the lung and kidney significantly increased in offspring born to heterotypic virus-infected mothers. Thus, vascular leakage indicates severe DV infection. The results indicate that maternal immunity increases the severity of subsequent heterotypic infection. Additionally, secondary cross infection by D13113 and YNWS2 represents a risk of serious disease. This study has implications for studies of DV cross infection and vaccine development.

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Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

Benelli

Maggi

Pavela

et al. 2017

Environ Sci Pollut Res

124

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The rapid spread of highly aggressive arboviruses, parasites, and bacteria along with the development of resistance in the pathogens and parasites, as well as in their arthropod vectors, represents a huge challenge in modern parasitology and tropical medicine. Eco-friendly vector control programs are crucial to fight, besides malaria, the spread of dengue, West Nile, chikungunya, and Zika virus, as well as other arboviruses such as St. Louis encephalitis and Japanese encephalitis. However, research efforts on the control of mosquito vectors are experiencing a serious lack of eco-friendly and highly effective pesticides, as well as the limited success of most biocontrol tools currently applied. Most importantly, a cooperative interface between the two disciplines is still lacking. To face this challenge, we have reviewed a wide number of promising results in the field of green-fabricated pesticides tested against mosquito vectors, outlining several examples of synergy with classic biological control tools. The non-target effects of green-fabricated nanopesticides, including acute toxicity, genotoxicity, and impact on behavioral traits of mosquito predators, have been critically discussed. In the final section, we have identified several key challenges at the interface between "green" nanotechnology and classic biological control, which deserve further research attention.

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Micro-anatomical changes in major blood vessel caused by dengue virus (serotype 2) infection

Cited by 5 publications

References 47 publications

Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences

Repeated infections of dengue (serotype DENV-2) in lung cells of BALB/c mice lead to severe histopathological consequences

Secondary cross infection with dengue virus serotype 2/3 aggravates vascular leakage in BALB/c mice

Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

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