Micelles and X-rays

Philippoff, W.

doi:10.1016/0095-8522(50)90018-3

Cited by 40 publications

(10 citation statements)

References 48 publications

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“…In addition, the solubility of silymarin in FI (130.8 mg/mL) was closer to that in polysorbate 20 whose structure was similar with Cremophor EL (130 mg/mL (6)), which demonstrated that solubilization efficiency for silymarin in SMEDDS was similar to that in polysorbate 20 alone, thereby the safety was enhanced due to the fact that low content of emulsifier was used in SMEDDS. It was reported that the mechanism about solubilization of substance in microemulsion or micelle could be investigated by X-ray, UV, or nuclear magnetic resonance (25)(26)(27). As seen from Fig.…”

Section: Physicochemical Properties Of Silymarin In Microemulsionmentioning

confidence: 95%

Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability

Yuan

Huang

et al. 2010

AAPS PharmSciTech

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Abstract. The objective of this work was to develop a self-microemulsifying drug delivery system (SMEDDS) for improving oral absorption of poorly water-soluble drug, silymarin. The pseudo-ternary phase diagrams were constructed using ethyl linoleate, Cremophor EL, ethyl alcohol, and normal saline to identify the efficient self-microemulsification region. The particle size and its distribution of the resultant microemulsions were determined using dynamic light scattering. The optimal formulation with the best self-microemulsifying and solubilization ability consisted of 10% (w/w) of ethyl linoleate, 30% of Cremophor EL, and 60% of ethyl alcohol. The release of silymarin from SMEDDS was significantly faster than that from the commercial silymarin preparation hard capsule (Legalon®). The bioavailability results indicated that the oral absorption of silymarin SMEDDS was enhanced about 2.2-fold compared with the hard capsule in fasted dogs. It could be concluded that SMEDDS would be a promising drug delivery system for poorly water-soluble drugs by the oral route.

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Section: Physicochemical Properties Of Silymarin In Microemulsionmentioning

confidence: 95%

Development of Silymarin Self-Microemulsifying Drug Delivery System with Enhanced Oral Bioavailability

Yuan

Huang

et al. 2010

AAPS PharmSciTech

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“…Of the many structures proposed initially for micelles, viz., spherical [Hartley (1936)], lamellar [McBain (1939)], cylindrical or rod shape [Debye and Anacker (1951)], disk-shaped (Harkins and Mittelmann (1949)], and hexagonal lamellae (Philippoff (1950)], at least three structures are now recognized as the most likely to exist at differ concentrations.…”

Section: Micelle Structuresmentioning

confidence: 99%

Surface Chemistry of Froth Flotation

Leja¹

1981

259

147

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“…These solubilization sites are mainly determined from studies on the solubilizates before and after solubilization, through nuclear magnetic reso- 1 To whom correspondence should be addressed. nance (NMR) spectroscopy (5), ultraviolet (UV) spectroscopy (11), and X-ray diffraction (12). NMR and UV studies indicate changes in the environment of the solubilizate on solubilization, whereas X-ray diffractograms provide information on changes in micellar dimensions on solubilization.…”

Section: Introductionmentioning

confidence: 99%