Micellar Properties of Drugs: Determination of Molecular Weight, Size, and Molecular Interactions of Drug Micelles Using the Analytical Ultracentrifuge

The magnitude of the UV-spectral change of chlorpromazine increases in the presence of increasing concentrations of alcohols or fatty acids and with increasing chain length. A maximum is reached with 14.0- or 16.0-fatty acids. The differential spectrum is still larger with unsaturated fatty acids, a maximum effect being obtained with one cis-double bond. The spectral change is abolished by chaotropic and enhanced by antichaotropic agents.

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Micellar Properties of Drugs: Determination of Molecular Weight, Size, and Molecular Interactions of Drug Micelles Using the Analytical Ultracentrifuge

Cited by 9 publications

References 29 publications

Pharmaceutical Sciences—1974: Literature Review of Pharmaceutics

Pharmaceutical Sciences—1974: Literature Review of Pharmaceutics

Micellar Distribution Equilibria: Ultracentrifugal Study of Apparent Partition Coefficients

Interaction of chlorpromazine with organic solvents and fatty acids as studied by UV-spectrophotometry

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