Micellar electrokinetic chromatography—mass spectrometry using a high-molecular-mass surfactant on-line coupling with an electrospray ionization interface

Ozaki, H.; Itou, Noritaka; Terabe, Shigeru; Takada, Yuki; Sakairi, Masatoshi; Koizumi, Hideaki

doi:10.1016/0021-9673(95)00596-f

Cited by 95 publications

(53 citation statements)

References 24 publications

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“…More recently, polymeric nanoparticle (NP) PSPs have been introduced and their separation performance characterized [32][33][34][35][36][37][38][39][40][41][42]. Polymeric and NP PSPs have also been shown to have significant advantages for use with electrospray ionization and mass spectrometric (MS) detection [37,[43][44][45][46][47][48][49][50][51][52], as well as for the separation of hydrophobic compounds not easily resolved with micellar PSPs [22,[53][54][55][56][57].…”

Section: Introductionmentioning

confidence: 99%

Retention behavior and selectivity of a latex nanoparticle pseudostationary phase for electrokinetic chromatography

et al. 2011

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The retention characteristics and separation selectivity of a novel latex nanoparticle (NP) pseudostationary phase (PSP) for electrokinetic chromatography have been characterized. The anionic NPs have very low or no affinity for cationic solutes, but show significant interactions and retention based on hydrophobic interactions. Retention factors of alkyl-phenyl ketones increase linearly with the concentration of the NPs and have zero or near zero y-intercepts as expected for electrokinetic chromatography with non-micellar PSPs. The retention factors of these solutes and representative pharmaceuticals decrease logarithmically with increases in the concentration of ACN in the background electrolyte, as expected for reversed-phase retention. Linear solvation energy relationship analysis indicates that the NPs are less cohesive than would be expected for polymeric PSPs with similar structure but that the overall separation selectivity can be expected to be similar to polymer PSPs with similar backbone chemistry. The results indicate that the hydrophobic core of the NPs is non-cohesive and is highly accessible to solutes, whereas the ionic head groups are not as accessible and do not contribute substantially to retention or selectivity.

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Section: Introductionmentioning

confidence: 99%

Retention behavior and selectivity of a latex nanoparticle pseudostationary phase for electrokinetic chromatography

et al. 2011

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“…However, their preparation and purification are rather complicated and, mainly, these pseudostationary phases are so far not commercially available. The other alternative is offered by polyvinylpyrrolidone-based pseudostationary phases [23] and commercially available polymers consisting of methacrylic acid and alkyl methacrylate copolymers [24][25][26][27].…”

Section: Advances In Pseudostationary Phases For Micellar Electrokinementioning

confidence: 99%

Advances in capillary electrophoresis

Deyl

Mikšı́k

Tagliaro

1998

Forensic Science International

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This review summarizes the advancement in operational modes and selected applications of the title technique over the past five years. Regarding operational modes particular emphasis is put upon increasing selectivity and resolution, hyphenation of capillary electrophoresis with techniques based on other than electromigration principles, the so-called chip technology and new ways of detection. In applications selected examples of chiral separations and separation of biopolymers (proteins, nucleic acids) are emphasized. It is demonstrated that capillary electrophoresis represents a complementary technique to high-performance column chromatography and in a number of cases it offers better separations than standard chromatographic procedures.

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“…In a BBMA-MEKC-ESI-MS system, some quat e rn a ry ammonium salts, alkaloids, and sulfamides [14] and three xanthine derivat ives [15] (Fi g. 3) we re successfully sep arated and detected. In DMA-MEKC-ESI-MS, a test mixture i n cluding pheny l t ri m e t hylammonium ch l o ri d e, 1 -n ap h t hyl a m i n e, quinine sulfat e, t e t rap h e nylphosphonium ch l o ri d e, and octaox ye t hylenedodecanol was successfully sep a rat e d and detected [16].…”

Section: Hmms-mekc-msmentioning

confidence: 99%

“…There have been some papers on HMMS-MEKC [9][10][11][12][13][14][15][16], in which sodium 10-undecenyl sulfate (SUS) oligomer, sodium u n d e cy l e n ate oligomer (SUA ) , butyl acry l at e -bu t y l m e t h a c ry l at e -m e t h a c rylic acid copolymer sodium salt (BBMA), and diisobutylene-maleic acid copolymer sodium salt (DMA) were used as pseudo-stationary phases. The critical micelle concentration (CMC) of HMMS should be effectively zero and hence, HMMS is expected to be an ideal p s e u d o -s t at i o n a ry phase of MEKC coupled with ESI-MS because of the stability or the formation of the micelle at low surfactant concentration.…”

Section: Hmms-mekc-msmentioning

confidence: 99%