Micellar and liquid-crystalline properties of bicyclic fragment-containing cationic surfactant

Гайсин, Н. К.; Гнездилов, О. И.; Pashirova, Tatiana N.; Zhil’tsova, E. P.; Лукашенко, С. С.; Zakharova, L. Ya.; Osipova, V. V.; Dzhabarov, V. I.; Galyametdinov, Yu. G.

doi:10.1134/s1061933x10060062

Cited by 17 publications

(18 citation statements)

References 24 publications

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“…10 Anisotropic systems cause a deviation in the plane of polarized light (birefringence, similar to real crystals), resulting in typical black and white images, or colored textures when using an additional λ-plate. They can be classified according to their texture as: 1) lamellar liquid crystalline phase, with the micrograph showing oily streaks with "Maltese crosses" and 2) hexagonal liquid crystalline structure, indicated by a fan-like texture.…”

Section: Polarized Light Microscopymentioning

confidence: 99%

“…17 Investigations of the behavior of liquid crystal phases have been performed by combining PLM, for preliminary identification of the nanostructure, and SAXS measurements, to confirm the liquid crystalline phase and obtain a better understanding of the spacing ratio. 7,10,46 SAXS is considered the "gold standard" technique for determination of the internal symmetry (or mesophase) of liquid crystal systems. 17 The mesophase of liquid crystalline structures can be determined according to relationships among the distances of the Bragg peaks on the scattering vector (q).…”

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confidence: 99%

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Physicochemical characterization of drug nanocarriers

Manaia

Abuçafy

Chiari-Andréo

et al. 2017

IJN

138

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Pharmaceutical design has enabled important advances in the prevention, treatment, and diagnosis of diseases. The use of nanotechnology to optimize the delivery of drugs and diagnostic molecules is increasingly receiving attention due to the enhanced efficiency provided by these systems. Understanding the structures of nanocarriers is crucial in elucidating their physical and chemical properties, which greatly influence their behavior in the body at both the molecular and systemic levels. This review was conducted to describe the principles and characteristics of techniques commonly used to elucidate the structures of nanocarriers, with consideration of their size, morphology, surface charge, porosity, crystalline arrangement, and phase. These techniques include X-ray diffraction, small-angle X-ray scattering, dynamic light scattering, zeta potential, polarized light microscopy, transmission electron microscopy, scanning electron microcopy, and porosimetry. Moreover, we describe some of the commonly used nanocarriers (liquid crystals, metal–organic frameworks, silica nanospheres, liposomes, solid lipid nanoparticles, and micelles) and the main aspects of their structures.

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Section: Polarized Light Microscopymentioning

confidence: 99%

mentioning

confidence: 99%

Physicochemical characterization of drug nanocarriers

Manaia

Abuçafy

Chiari-Andréo

et al. 2017

IJN

138

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“…In particular, it has been shown 5,6 that unlike typical surfactants, large aggregates with hydrodynamic diameters ²100 nm are formed in DABCO-16 solution upon aging for three days. These large asymmetric aggregates are probably precursors for the thermotropic and lyotropic liquid crystals revealed by polarization microscopy.…”

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confidence: 99%

“…These large asymmetric aggregates are probably precursors for the thermotropic and lyotropic liquid crystals revealed by polarization microscopy. 6 It is known that cationic agents can be used as drug and gene delivery systems 7,8 owing to their high affinity for the phosphate anions of DNA. Therefore, the complexation of cationic surfactants with an oligonucleotide (GCGTTAACGC; A, C, G, and T are adenine, cytosine, guanine, and thymine, respectively) was investigated.…”

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confidence: 99%

Comparative Study of Aqueous Solutions of Cationic Surfactants: Structure/Activity Relation in Their Aggregation and Solubilization Behavior and Complexation with an Oligonucleotide

et al. 2012

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For mono-and dicationic surfactants with trimethylammonium (TMA), triphenylphosphonium (TPP), and 4-aza-1-alkyl-1-azoniabicyclo[2.2.2]octane (DABCO) polar groups, and also for pyrimidinic amphiphiles, a correlation is revealed between their aggregation and solubilization properties and their complexation capacity toward an oligonucleotide. Mixed cationic surfactantcalixarene systems demonstrate controllable binding/ release properties.Cationic surfactants are very attractive for the design of catalytic systems, analytical separation, antimicrobial compositions, and synthetic vectors for gene delivery.1,2 In these strategies, the capacity of surfactants to adsorb on surfaces or to bind guest molecules is utilized. Nanocontainers based on surfactants are noncovalently bound dynamic structures, and they should therefore be competitive with carriers based on covalently formed polymer containers and polyelectrolyte capsules fabricated by the layer-by-layer technique. The advantages of surfactant-based nanocontainers are their easy preparation, versatile uses, controlled morphology and size, low required concentration, and biocompatibility. Therefore, to be competitive from the viewpoint of current technologies, cationic surfactants have to meet the above criteria and exhibit high micellization and solubilization capacities and low toxicity. The morphology of aggregates, their binding capacity, and hence, their functional activity depend to a great extent on the chemical structure of amphiphiles. Herein, micellar systems based on cationic surfactants are studied with variation of the nature of the charge atoms. In particular, mono-and dicationic surfactants with trimethylammonium (TMA-n), triphenylphosphonium (TPP-n), and 4-aza-1-alkyl-1-azoniabicyclo[2.2.2]octane (DABCO-n) polar groups, as well as pyrimidinic mono-and dicationic amphiphiles, are considered, with the number of carbon atoms in the alkyl chain n varied from 8 to 18. The data obtained are exemplified by the hexadecyl derivatives TMA-16, Generally, different methods are used to estimate the aggregation behavior, in particular, tensiometry, conductometry, NMR self-diffusion, dye solubilization studies, and so on. The data obtained are analyzed in terms of the concentration dependences of the measured parameters, and breakpoints in the plots are identified as critical micelle concentrations (cmc's). These values indicate the onset of micellization in the systems. In our earlier works, 36 the micellization of cationic surfactants with different headgroups was studied through a combination of methods. Surfactants with charged nitrogen (TMA and DABCO series) showed very similar cmc's of around 1 mM, while phosphonium salts demonstrated much lower cmc values.3,5 The advantages in terms of micellization capacity may result in more effective functional activity. Therefore, the purpose of this study is to compare their binding capacity toward different guests, including hydrophobic organic substrates and an oligonucleotide.As seen in Figure 1, a higher solubiliza...

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“…To characterize the liquid-crystalline structures of the formulations, we used polarized light microscopy for preliminary identification 43 and small-angle X-ray scattering (SAXS) measurements to confirm the liquid-crystalline phase. Figure 4 shows the photomicroscopic images of the formulation F1 containing TP and the SAXS curves of the F1 and F5 formulations.…”

mentioning

confidence: 99%

Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release

Manaia¹,

Kaminski²,

Oliveira³

et al. 2015

IJN

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Multifunctional products have been developed to combine the benefits of functional components and terpinen-4-ol (TP) delivery systems. In this way, p-toluene sulfonic acid modified titanium dioxide (TiO 2 ) nanoparticles and TP, an antioxidant, have been incorporated in liquid-crystalline formulations for photoprotection and controlled release of the TP, respectively. By X-ray powder diffraction and diffuse reflectance spectroscopy, we noted that using p-toluene sulfonic acid as a surface modifier made it possible to obtain smaller and more transparent TiO 2 nanoparticles than those commercially available. The liquid-crystalline formulation containing the inorganic ultraviolet filter was classified as broad-spectrum performance by the absorbance spectroscopy measurements. The formulations containing modified TiO 2 nanoparticles and TP were determined to be in the hexagonal phase by polarized light microscopy and small-angle X-ray scattering, which makes possible the controlled released of TP following zero-order kinetics. The developed formulations can control the release of TP. Constant concentrations of the substance have been released per time unit, and the modified TiO 2 nanoparticles can act as a transparent inorganic sunscreen.

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Micellar and liquid-crystalline properties of bicyclic fragment-containing cationic surfactant

Cited by 17 publications

References 24 publications

Physicochemical characterization of drug nanocarriers

Physicochemical characterization of drug nanocarriers

Comparative Study of Aqueous Solutions of Cationic Surfactants: Structure/Activity Relation in Their Aggregation and Solubilization Behavior and Complexation with an Oligonucleotide

Multifunction hexagonal liquid-crystal containing modified surface TiO2 nanoparticles and terpinen-4-ol for controlled release

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