Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability

Dey, Sandeep Kumar; Kamle, Avijeet; Dereddi, Ram Reddy; Thomas, Shiju M; Thummala, Shashi Rekha; Kumar, Arvind; Chakravarty, Sumana; Jesudasan, Rachel A.

doi:10.3389/fnbeh.2018.00215

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…The open field test is used for assessment of locomotor activity and anxiety like behavior (Keers et al, 2012).Briefly mice were habituated to the testing room (1 h), then placed in the same starting corner of a novel open field arena (40 cm × 40 cm × 40 cm) and allowed to freely explore for 5 min after which they were returned to their home cage. The floor of the open field apparatus was virtually divided into 16 equal squares where the four innermost squares comprised the inner zone and the twelve outer squares adjacent to the arena walls comprised the outer zone (Dey et al, 2018). The illumination was kept at 100 lux (Ueno et al, 2020).…”

Section: Open Field Testmentioning

confidence: 99%

High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling

et al. 2021

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The neurobiological mechanisms that mediate psychiatric comorbidities associated with metabolic disorders such as obesity, metabolic syndrome and diabetes remain obscure. High fructose corn syrup (HFCS) is widely used in beverages and is often included in food products with moderate or high fat content that have been linked to many serious health issues including diabetes and obesity. However, the impact of such foods on the brain has not been fully characterized. Here, we evaluated the effects of long-term consumption of a HFCS-Moderate Fat diet (HFCS-MFD) on behavior, neuronal signal transduction, gut microbiota, and serum metabolomic profile in mice to better understand how its consumption and resulting obesity and metabolic alterations relate to behavioral dysfunction. Mice fed HFCS-MFD for 16 weeks displayed enhanced anxiogenesis, increased behavioral despair, and impaired social interactions. Furthermore, the HFCS-MFD induced gut microbiota dysbiosis and lowered serum levels of serotonin and its tryptophan-based precursors. Importantly, the HFCS-MFD altered neuronal signaling in the ventral striatum including reduced inhibitory phosphorylation of glycogen synthase kinase 3β (GSK3β), increased expression of ΔFosB, increased Cdk5-dependent phosphorylation of DARPP-32, and reduced PKA-dependent phosphorylation of the GluR1 subunit of the AMPA receptor. These findings suggest that HFCS-MFD-induced changes in the gut microbiota and neuroactive metabolites may contribute to maladaptive alterations in ventral striatal function that underlie neurobehavioral impairment. While future studies are essential to further evaluate the interplay between these factors in obesity and metabolic syndrome-associated behavioral comorbidities, these data underscore the important role of peripheral-CNS interactions in diet-induced behavioral and brain function. This study also highlights the clinical need to address neurobehavioral comorbidities associated with obesity and metabolic syndrome.

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Section: Open Field Testmentioning

confidence: 99%

High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling

et al. 2021

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Satellite DNAs and human sex chromosome variation

Čechová

Miga

2022

Seminars in Cell & Developmental Biology

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Analysis of Y chromosome haplogroups in Parkinson’s disease

Grenn

Makarious

Bandrés‐Ciga

et al. 2022

Brain Communications

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Parkinson's disease is a complex neurodegenerative disorder that is about 1.5 times more prevalent in males than females. Extensive work has been done to identify the genetic risk factors behind Parkinson's disease on autosomes and more recently on chromosome X, but work remains to be done on the male specific Y chromosome. In an effort to explore the role of the Y chromosome in Parkinson's disease we analyzed whole genome sequencing data from the Accelerating Medicines Partnership - Parkinson's disease initiative (1,466 cases and 1,664 controls), genotype data from NeuroX (3,491 cases and 3,232 controls), and genotype data from UKBiobank (182,517 controls, 1,892 cases, and 3,783 proxy cases) all consisting of male European ancestry samples. We classified sample Y chromosomes by haplogroup using three different tools for comparison (Snappy, Yhaplo, and Y-LineageTracker), and meta-analyzed this data to identify haplogroups associated with Parkinson's disease. This was followed up with a Y chromosome association study to identify specific variants associated with disease. We also analyzed blood based RNASeq data obtained from the Accelerating Medicines Partnership - Parkinson's disease initiative (1,020 samples) and RNASeq data obtained from the North American Brain Expression Consortium (171 samples) to identify Y chromosome genes differentially expressed in cases, controls, specific haplogroups, and specific tissues. RNASeq analyses suggest Y chromosome gene expression differs between brain and blood tissues but does not differ significantly in cases, controls or specific haplogroups. Overall, we did not find any strong associations between Y chromosome genetics and Parkinson's disease, suggesting the explanation for increased prevalence in males may lie elsewhere.

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Mice With Partial Deletion of Y-Heterochromatin Exhibits Stress Vulnerability

Cited by 3 publications

References 61 publications

High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling

High Fructose Corn Syrup-Moderate Fat Diet Potentiates Anxio-Depressive Behavior and Alters Ventral Striatal Neuronal Signaling

Satellite DNAs and human sex chromosome variation

Analysis of Y chromosome haplogroups in Parkinson’s disease

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