Mice overexpressing chromogranin A display hypergranulogenic adrenal glands with attenuated ATP levels contributing to the hypertensive phenotype

Mir, Saiful A.; Li, Ying; Story, Jacob D.; Bal, Soma; Awdishu, Linda; Street, Anneke A.; Mehta, Ravindra L.; Singh, Prabhleen; Vaingankar, Sucheta M.

doi:10.1097/hjh.0000000000001678

Cited by 3 publications

(1 citation statement)

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“…We analyzed the relationships between these five proteins and identified the “CHGA” protein. Elevated CHGA levels result in UCP2 overexpression in hypertension[ 48 ]. We evaluated these changes in hRMECs treated with high glucose and STZ mouse retinas and observed increased protein expression of CHGA, UCP2, and GLUT1.…”

Section: Discussionmentioning

confidence: 99%

Genipin relieves diabetic retinopathy by down-regulation of advanced glycation end products via the mitochondrial metabolism related signaling pathway

Sun,

Chen,

et al. 2023

World J Diabetes

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Diabetes and associated complications represent major global public health issues which are associated with impaired quality of life and premature death. Although some diabetic complications have decreased in the developed world, the majority are still prevalent, with an increasing trend in the developing world. Currently used therapies are mainly ‘glucocentric’, focusing on the optimization of glycemic control to prevent, delay or manage diabetes-associated complications- other common comorbidities, such as dyslipidemia and hypertension are often underestimated. Although a number of novel therapeutic approaches have been reported recently, some of them have not received comparable attention in relation to either further studies or potential clinical implementation. This editorial briefly discusses some recent therapeutic approaches to the prevention and management of diabetes and its associated complications, as well as potential directions for future research and development in this area.

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Section: Discussionmentioning

confidence: 99%