Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways

Saku, Aiko; Suehiro, Kenichi; Nakamura, Kazuko; Nishimura, Nozomi; Yokota, Masaya; Hirose, Koichi; Nakajima, Hiroshi

doi:10.1111/all.14101

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…14 IL-33 activates fucosyltransferase 2 which induces the fucosylation of BEC, paramount for sustained ILC2 activation. 15 In addition, human BEC expresses functional IL-5 receptor, the stimulation of which contributes to the impairment of epithelial barrier integrity. 16 BECs express soluble interleukin 1 receptor-like 1 (ST2) and IL-33 stimulation increases intracellular calcium, alters gene expression, but has no effect upon wound repair.…”

Section: Innate Immunitymentioning

confidence: 99%

“…A reciprocal positive feedback loop between TSLP and IL‐33 further amplifies the inflammation 14 . IL‐33 activates fucosyltransferase 2 which induces the fucosylation of BEC, paramount for sustained ILC2 activation 15 . In addition, human BEC expresses functional IL‐5 receptor, the stimulation of which contributes to the impairment of epithelial barrier integrity 16 .…”

Section: Asthma Pathophysiological Mechanismsmentioning

confidence: 99%

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Advances and highlights in asthma in 2021

Agache

Eguiluz‐Gracia

Cojanu

et al. 2021

Allergy

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Last year brought a significant advance in asthma management, unyielding to the pressure of the pandemics. Novel key findings in asthma pathogenesis focus on the resident cell compartment, epigenetics and the innate immune system. The precision immunology unbiased approach was supplemented with novel tools and greatly facilitated by the use of artificial intelligence. Several randomised clinical trials and good quality realworld evidence shed new light on asthma treatment and supported the revision of several asthma guidelines (GINA, Expert Panel Report 3, ERS/ATS guidelines on severe asthma) and the conception of new ones (EAACI Guidelines for the use of biologicals in severe asthma). Integrating asthma management within the broader context of Planetary Health has been put forward. In this review, recently published articles and clinical trials are summarised and discussed with the goal to provide clinicians and researchers with a concise update on asthma research from a translational perspective.

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Section: Innate Immunitymentioning

confidence: 99%

Section: Asthma Pathophysiological Mechanismsmentioning

confidence: 99%

Advances and highlights in asthma in 2021

Agache

Eguiluz‐Gracia

Cojanu

et al. 2021

Allergy

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“…Indeed, CysLT is an effective inflammatory mediator that promotes the occurrence of SAR 31 . One recent study has investigated the relationship between epithelial fucosylation and innate allergic airway inflammation in mice, particularly as lung epithelial cells have been shown to be heavily fucosylated by fucosyltransferase (FUT) 2 in HDM‐induced asthma model and the development of allergic inflammation is attenuated in FUT 2‐deficient animals 32 . The authors further demonstrated that FUT 2‐mediated fucosylation of epithelial cells led to the local production of complement 3a (C3a).…”

Section: Mechanismsmentioning

confidence: 99%

“…The authors further demonstrated that FUT 2-mediated fucosylation of epithelial cells led to the local production of complement 3a (C3a). Furthermore, in the airways of mice lacking FUT 2, decreased C3a production led to a decrease of IL-33-induced inflammation and accumulation of ILC2s 32.…”

mentioning

confidence: 92%

Advances and novel developments in allergic rhinitis

Meng

Wang

Zhang

2020

Allergy

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Allergic rhinitis (AR) is an upper airway disease with high prevalence in the world, and therefore needs to be thoroughly investigated and treated accordingly. Although the mechanisms underlying the pathology and treatment of AR have been widely studied, many aspects of AR are still unclear and warrant further investigations. The purpose of the present review was therefore to report recently published papers, which highlight the novel mechanisms and treatments of AR. These include role of environment, important proteins and cells, and some other factors in the pathogenesis of AR; as well as the role of immunotherapy and biologics in the treatment of AR.

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Mice lacking fucosyltransferase 2 show reduced innate allergic inflammation in the airways

Abstract: 'Genetic predictors of drug hypersensitivity' of the European Network on Drug Allergy (ENDA) of EAACI. Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.

Cited by 2 publications

References 8 publications

Advances and highlights in asthma in 2021

Advances and highlights in asthma in 2021

Advances and novel developments in allergic rhinitis

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