Mice genetically selected for differences in open-field activity after ethanol

Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis

“…FAST-1 and 2 mice exhibit extreme sensitivity, whereas SLOW-1 and 2 mice exhibit insensitivity, to EtOH-induced locomotor stimulation in the absence of consistent differences in basal activity (Crabbe et al 1987;Phillips et al 1991;. EtOH-stimulated activity was attenuated by dopamine receptor antagonists in FAST mice (Shen et al 1995a).…”

A role for neuronal nicotinic acetylcholine receptors in ethanol-induced stimulation, but not cocaine- or methamphetamine-induced stimulation

“…FAST and SLOW mice were selectively bred for their differential sensitivity to the stimulant effects of EtOH (Crabbe et al 1987;Phillips et al 1991Phillips et al , 2002Shen et al 1995). FAST mice, which were bred for heightened sensitivity to the stimulant effects of EtOH, were more sensitive to the stimulant effects of COC and MA compared to SLOW mice (Bergstrom et al 2003).…”

GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol

“…The two activity tests were performed 24-h apart. Subsequent to selection generation 37 (S 37 ), breeding of the FAST and SLOW lines has been performed under relaxed selection conditions, with mice chosen randomly and bred within line (Crabbe et al, 1987(Crabbe et al, , 1988Phillips et al, 1991Phillips et al, , 2002Shen et al, 1995b) Experimentally naïve male FAST-1 and FAST-2 mice from the S 37 G 72-76 generations (S xx refers to the number of selection generations; G yy refers to the total number of elapsed generations since the beginning of selection) were used for the current studies. Only male mice were used due to their greater availability and because previous studies using baclofen in FAST mice did not find sex-specific effects (Boehm et al, 2002;Shen et al, 1998).…”

“…Boehm et al, 2002;Castelli et al, 2005;Chester and Cunningham, 1999;Leite-Morris et al 2002, 2004Shen et al, 1998;Tsuji et al, 1996;Woo et al, 2001). The FAST and SLOW selected mouse lines, which were bred, in replicate, for heightened and reduced sensitivity to the locomotor stimulant effects of ethanol (Crabbe et al, 1987;Phillips et al, 1991;Shen et al, 1995b), also differ in their locomotor response to morphine (Bergstrom et al, 2003;Holstein et al, 2005). This genetic correlation suggests that some of the same alleles that influence sensitivity to the selection trait (ethanol-induced locomotion), and thus some common neurobiological mechanisms, contribute to sensitivity to the locomotor effects of morphine (see Crabbe et al, 1990).…”