Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis

Boehm, Stephen L.; Reed, Cheryl; McKinnon, Carrie S.; Phillips, Tamara J.

doi:10.1007/s00213-002-1000-y

Cited by 25 publications

(21 citation statements)

References 41 publications

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“…Indeed, data from the study of Boerngen-Lacerda and Souza-Formigoni (2000) suggest that the stimulant and anxiolytic effects of ethanol are mediated by distinct mechanisms. Also, it is known that the genes influencing locomotor sensitivity and those influencing anxiety-related behavior are likely to be partially overlapping sets, rather than identical (Boehm II et al, 2002). Although we did not conduct a correlation analysis between the time spent in the open arms of the EPM and locomotor activity scores in the OF, the large differences detected in these experiments, mainly in the OF measures, lead us to indicate that the sensitivity to ethanol-induced locomotor activation could be the behavioral predictor for the ethanol consumption experiments in the SHR strain.…”

Section: Discussionmentioning

confidence: 99%

Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats

Silva¹,

Vendruscolo

Takahashi

2005

Life Sciences

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Section: Discussionmentioning

confidence: 99%

Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats

Silva¹,

Vendruscolo

Takahashi

2005

Life Sciences

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“…Results with these drugs indicate that voluntary reentry time most likely represents drug effects on anxiety-like behavior and not activity. The other drugs tested have known effects on anxiety-like behavior (Lister 1987;Cole et al 1995;Rodgers et al 1995;Boehm et al 2002) but also have robust effects on activity, such that disentangling locomotor activation from behaviors indicative of anxiety becomes difficult.…”

Section: Discussionmentioning

confidence: 99%

Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice

2003

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Since control animals reliably reentered the more aversive portion of the apparatus for 25% of the total time available, the modified mirrored chamber may be able to detect anxiogenic states produced by various stressors and drug withdrawal. Further, the strain differences detected suggest that the modified mirrored chamber will be a valuable tool in the discovery of the genetic bases of anxiety states and disorders.

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“…Studies in rodents indicate a shared genetic sensitivity to ethanol, anxiety and stress/HPA axis response (Boehm et al 2002; Crabbe et al 1999). We have identified the genetic regulation of basal levels of the neuroactive steroid DOC across the C57BL/6J (B6)×DBA/2J (D2) (BXD) recombinant inbred mouse strains, a reference population to study networks of phenotypes and their modulation by gene variants (Gora-Maslak et al 1991; Williams et al 2001).…”

Section: Genetic Variation In Neuroactive Steroid Levels Across Bxd Rmentioning

confidence: 99%

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

Porcu

Morrow

2014

Psychopharmacology

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Rationale Neuroactive steroids are endogenous or synthetic steroids that rapidly alter neuronal excitability via membrane receptors, primarily GABAA receptors. Neuroactive steroids regulate many physiological processes including hypothalamic-pituitary-adrenal (HPA) axis function, ovarian cycle, pregnancy, aging, and reward. Moreover, alterations in neuroactive steroid synthesis are implicated in several neuropsychiatric disorders. Objectives This review will summarize the pharmacological properties and physiological regulation of neuroactive steroids, with a particular focus on divergent neuroactive steroid responses to stress and ethanol in rats, mice and humans. Results GABAergic neuroactive steroids exert a homeostatic regulation of the HPA axis in rats and humans, whereby the increase in neuroactive steroid levels following acute stress counteracts HPA axis hyperactivity and restores homeostasis. In contrast, in C57BL/6J mice, acute stress decreases neurosteroidogenesis and neuroactive steroids exert paradoxical excitatory effects upon the HPA axis. Rats, mice and humans also differ in the neuroactive steroid responses to ethanol. Genetic variation in neurosteroidogenesis may explain the different neuroactive steroid responses to stress or ethanol. Conclusions Rats and mouse strains show divergent effects of stress and ethanol on neuroactive steroids in both plasma and brain. The study of genetic variation in the various processes that determine neuroactive steroids levels as well as their effects on cell signaling may underlie these differences and may play a relevant role for the potential therapeutic benefits of neuroactive steroids.

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Shared genes influence sensitivity to the effects of ethanol on locomotor and anxiety-like behaviors, and the stress axis

Abstract: These results provide evidence that sensitivity to the effects of EtOH on locomotor behavior, anxiety-like behavior, and the stress axis share some genetic influence.

Cited by 25 publications

References 41 publications

Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats

Effects of ethanol on locomotor and anxiety-like behaviors and the acquisition of ethanol intake in Lewis and spontaneously hypertensive rats

Validation of a modified mirrored chamber sensitive to anxiolytics and anxiogenics in mice

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies

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