MICA haplotypic diversity

Fodil, Nassima; Pellet, Philippe; Laloux, Laurent; Hauptmann, G.; Théodorou, Ioannis; Bahram, Seiamak

doi:10.1007/s002510050536

Cited by 61 publications

(67 citation statements)

References 10 publications

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“…Our main focus was the missing or discrepant MICA types for CEHs. We obtained the MICA types for CEHs 35 63 but our result agreed with that of another study. 68 Likewise, we confirmed the MICA type of the cell line HOR as *004 (but not as *007).…”

Section: Micasupporting

confidence: 80%

“…68 Likewise, we confirmed the MICA type of the cell line HOR as *004 (but not as *007). 63 The cell line CF996 was typed as MICA*019 by us in agreement with some others 68,71 but not with all. 65,66 The MICA type of cell line HO301 was *011 but not *008.…”

Section: Micamentioning

confidence: 61%

“…We only typed the cell lines that had inconsistent MICA results in the literature or representatives of CEHs with missing data 63,64,[67][68][69][70][71]128 (see Table 1 footnote). Our results were complemented with the data from IHWG Cell Line Bank (http://www.ihwg.org/shared/cbankover.htm) for cell lines represented in the MICA Reference Panel and IMGT/HLA Sequence Database (http:// www.ebi.ac.uk/imgt/hla/allele.html).…”

Section: Mica Strmentioning

confidence: 99%

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Conserved extended haplotypes of the major histocompatibility complex: further characterization

et al. 2006

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Since the complete sequencing of a human major histocompatibility complex (MHC) haplotype, interest in non-human leucocyte antigen (HLA) genes encoded in the MHC has been growing. Non-HLA genes, which outnumber the HLA genes, may contribute to or account for HLA and disease associations. Most information on non-HLA genes has been obtained in separate studies of individual loci. To comprehensively address polymorphisms of relevant non-HLA genes in 'conserved extended haplotypes' (CEH), we investigated 101 International Histocompatibility Workshop reference cell lines and nine additional anonymous samples representing all 37 unambiguously characterized CEHs at MICA, NFKBIL1, LTA, NCR3, AIF1, HSPA1A, HSPA1B, BF, NOTCH4 and a single nucleotide polymorphism (SNP) at HLA-DQA1 as well as MICA, NOTCH4, HSPA1B and all five tumour necrosis factor short tandem repeat (STR) polymorphisms. This work (1) provides an extensive catalogue of MHC polymorphisms in all CEHs, (2) unravels interrelationships between HLA and non-HLA haplotypical lineages, (3) resolves reported typing ambiguities and (4) describes haplospecific markers for a number of CEHs. Analysis also identified a DQA1 SNP and segments containing MHC class III polymorphisms that corresponded with class II (DRB3 and DRB4) lineages. These results portray the MHC where lineages containing non-HLA and HLA variants in linkage disequilibrium may operate in concert and can guide more thorough design and interpretation of HLA-disease relationships.

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Section: Micasupporting

confidence: 80%

Section: Micamentioning

confidence: 61%

Section: Mica Strmentioning

confidence: 99%

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Conserved extended haplotypes of the major histocompatibility complex: further characterization

et al. 2006

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“…33,34 Thus, MICA*008/5.1 is in linkage disequilibrium with HLA-B8 (-B*0801) but is also associated with HLA-B*0702, -B*1302, -B*4001, -B*4402, and -B*4701. 35 In our study, the combined presence of B8, MICA5.1, MICB24, and DR3 yielded a highly significant association to PSC. Most likely, these alleles are carried on the same haplotype.…”

Section: Discussionmentioning

confidence: 75%

Primary sclerosing cholangitis is associated to an extended B8-DR3 haplotype including particular MICA and MICB alleles

WIENCKE¹,

SPURKLAND²,

SCHRUMPF³

et al. 2001

Hepatology

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Susceptibility to primary sclerosing cholangitis (PSC) is associated with HLA-B8, -DR3, -DR2, and -DR6. It is not established whether these HLA genes or closely linked genes confer the primary disease susceptibility. MICA and MICB genes are found in the class I region between HLA-B and DRB. MICA is expressed in gastrointestinal epithelium and activates ␥␦ T cells in the gut. Because PSC is strongly associated with inflammatory bowel disease, we investigated whether MICA and MICB contribute to the HLA-associated genetic susceptibility to develop PSC. The study included 130 PSC patients and 306 healthy controls, previously typed for HLA class I and II genes, typed for 5 MICA and 15 MICB microsatellite alleles. The phenotype frequencies of MICA5.1 and MICB24 were significantly increased among PSC patients compared with controls (90% vs. 74%; odds ratio [OR] ‫؍‬ 3.2; P c ‫؍‬ 3 ؋ 10 ؊3 and 58% vs. 29%; OR ‫؍‬ 3.3; P c < 1 ؋ 10 ؊7 , respectively). When stratified for B8-or DR3-positive and -negative individuals, the association of these markers to PSC was no longer evident. However, we observed that B8 and DR3 were associated to PSC only in the presence of both MICA5.1 and MICB24 markers. The frequency of individuals carrying all 4 alleles was significantly increased among the PSC patients compared with controls (49% vs. 18%; OR ‫؍‬ 4.5; P c < 1 ؋ 10 ؊7 ). Our data indicate that PSC is associated to the extended B8-MICA5.1-MICB24-DR3 haplotype. (HEPATOLOGY 2001;34:625-630.)Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by inflammatory and fibrotic bile duct lesions forming multiple strictures and ectatic dilatations of the intra-and extrahepatic bile ducts.

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“…26,27 The sequences and the transmembrane microsatellite length were analyzed using SeqScape v2.6 and GeneMapper v4.0 software (ThermoFisher Scientific), respectively. Final MICA genotypes were assigned using an in-house-developed software that compiled sequence data and transmembrane genotypes.…”

Section: Mica Genotypingmentioning

confidence: 99%

Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

Carapito

Jung

Kwemou

et al. 2016

Blood

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MICA haplotypic diversity

Cited by 61 publications

References 10 publications

Conserved extended haplotypes of the major histocompatibility complex: further characterization

Conserved extended haplotypes of the major histocompatibility complex: further characterization

Primary sclerosing cholangitis is associated to an extended B8-DR3 haplotype including particular MICA and MICB alleles

Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD

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