MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line

Alipoor, Firooz Jannat; Asadi, Malek Hossein; Torkzadeh‐Mahani, Masoud

doi:10.1002/jcb.26678

Cited by 71 publications

(68 citation statements)

References 22 publications

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“…Studies have shown that the decline in yeast cell proliferation caused by aging and cell death is associated with G1/S phase transition disorders (22). Decreased cell proliferation levels and G1 phase cell arrest were also observed in senescent breast cancer cells (23). These studies suggest that the blockade of the G1/S phase transition and decreased cell proliferation levels are among the hallmarks of cellular senescence.…”

Section: Discussionmentioning

confidence: 88%

“…These studies suggest that the blockade of the G1/S phase transition and decreased cell proliferation levels are among the hallmarks of cellular senescence. In addition to cell cycle transformation disorders, increased expression of the cell senescence marker p16 can be observed (23). Previous studies have suggested that p16 inhibits function of cyclin-dependent kinases, causing G1 cell cycle arrest (18).…”

Section: Discussionmentioning

confidence: 99%

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Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging

Zheng

Huang

et al. 2020

Int. J. Med. Sci.

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The underlying mechanisms that mediate the effects of vitamin C on endothelial cell aging are widely unknown. To investigate whether Piwi-interacting RNAs (piRNAs) are involved in this process, an endothelial aging model was induced in vitro using H2O2 in human umbilical vein endothelial cells (HUVECs) and then treated with vitamin C (VC). Untreated HUVECs without H2O2 exposure were used to serve as the negative control group. Cell cycle, cell viability, and aging-associated protein expression were assessed, and RNA sequencing was performed to reveal the piRNA profile. Functional and regulatory networks of the different piRNA target genes were predicted by the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment and Gene Ontology (GO) analysis. H2O2 induced G1 phase cell arrest, decreased cell viability, and upregulated the senescence marker p16 in HUVECs. We found that VC treatment inhibited G1 phase cell arrest, increased the number of cells in the S and G2/M phases, increased cell viability, and decreased p16 expression. The piRNA expression profiles revealed that a large proportion of piRNAs that were differentially expressed in H2O2-treated HUVECs were partly normalized by VC. Furthermore, a number of piRNAs associated with the response to VC in H2O2-treated HUVECs were linked with senescence and cell cycle-related pathways and networks. These results indicate that the ability of VC to attenuate H2O2-mediated endothelial cell senescence may be associated with changes in expression of piRNAs that are linked to the cell cycle.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging

Zheng

Huang

et al. 2020

Int. J. Med. Sci.

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“…was recently found to be up-regulated in ER-positive BC tissues. 57,58 MIAT silencing in MCF-7 cells decreased cell proliferation while its overexpression increased MCF-7 cell proliferation. MIAT expression was critical for G1 to S-phase cell cycle transition.…”

Section: Lncrnas With Functional Rolesmentioning

confidence: 92%

“…The lncRNA myocardial infarction associated transcript (MIAT) was recently found to be up‐regulated in ER‐positive BC tissues . MIAT silencing in MCF‐7 cells decreased cell proliferation while its overexpression increased MCF‐7 cell proliferation.…”

Section: Lncrnas and Estrogen‐positive Subtypesmentioning

confidence: 99%

Long non‐coding RNAs differential expression in breast cancer subtypes: What do we know?

et al. 2019

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Breast Cancer (BC) is the most commonly diagnosed cancer and is the leading cause of cancer deaths in women. BC is a heterogeneous disease with different clinical and genetic features. According to immunohistochemical markers, BC is subdivided into four main subtypes: luminal A, luminal B, ERBB2 positive and triple negative. Long non‐coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides and deregulated lncRNAs are associated with human diseases, including BC. In order to improve BC molecular classification, non‐coding RNAs (ncRNAs), including lncRNAs, have been used. In this review, we focus on lncRNAs with differential expression in BC subtypes and how these RNAs may act to contribute to BC heterogeneity. We also emphasize the potential of these lncRNAs as biomarkers.

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“…MIAT is also disrupted in a number of cancer cell lines, and is expressed at significantly lower levels in grade I-II breast tumors, as compared to those considered high grade III-IV tumors [110] . MIAT also modulates the invasive capacities of breast cancer cells by mediating the ncRNA interaction networks between ZEB1 and certain miRNAs, such as miR-150 and miR-29 [173] . For instance, knockdown of MIAT promotes the expression of miR-150, yet also results in the reduction of miR-29 levels.…”

Section: Myocardial Infarction Associated Transcriptmentioning

confidence: 99%

The role of long noncoding RNAs in cancer metastasis

Parsons¹,

Tayoun²,

Benado³

et al. 2018

JCMT

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Signaling pathways are tightly controlled systems that regulate the appropriate timing of gene expression required for the differentiation of cells down a particular lineage essential for proper tissue development. Proliferation, apoptosis and metabolic pathways are just a few examples of the signaling pathways that require fine-tuning, so as to control the proper development of a particular tissue type or organ system. An estimated 70% of the genome is actively transcribed, only 2% of which codes for known protein-coding genes. Long noncoding RNAs (lncRNAs) in particular, are a large and diverse class of RNAs > 200 nucleotides in length, and not translated into protein. lncRNAs are essential transcriptional and post-transcriptional regulators that control the expression of genes in a spatial, temporal, and cell context-dependent manner. The aberrant expression of lncRNAs is therefore linked with a number of chronic diseases including cardiac dysfunction, diabetes, and cancer. In this review, we highlight the specific role lncRNAs have in promoting the metastatic cascade across a number of epithelial cancer models.

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MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line

Cited by 71 publications

References 22 publications

Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging

Piwi-interacting RNAs play a role in vitamin C-mediated effects on endothelial aging

Long non‐coding RNAs differential expression in breast cancer subtypes: What do we know?

The role of long noncoding RNAs in cancer metastasis

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