MHC class II sequences of susceptibility and protection in Mexicans with autoimmune hepatitis

Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB1*1301, a marker for pediatric autoimmune hepatitis

“…In Mexico, despite a high seroprevalence of HAV, only adult forms of type I AH associated with DRB1*0404 have been reported. 26 Interestingly, the phenotypic frequency of DRB1*1301 in the Mexican population is 5.1%, (Gorodezky C, personal communication, February 2001) versus 9.8% in Argentina and 13.2% in Brazil. When we compared the DRB1*1301 frequencies in different regions of the world, we found that DRB1*1301 ranged from 3% to 16% in the United States, 27,28 from 3% to 12% in Canada, 29,30 from 4% to 5% in Italy, 31,32 and from 3% to 15% in Spain.…”

Genetic background of autoimmune hepatitis in Japan

“…Molecular analysis of HLA DR by the use of PCR-based DNA typing techniques have shown that susceptibility to type 1 AIH is associated specifically with the DRB1*03:01 and DRB1*04:01 alleles in Caucasians [10], DRB1*04:05 in Japanese [11] , Koreans [12] and Argentine adults [13], DRB1*04:04 in Mexicans [14], and DRB1*13:01 in Argentine children [15] and Brazilians [15] in the HLA class II DRB1 locus, which encodes the polymorphic β chain of the HLA-DR antigen (Table 1). We earlier performed HLA-genotyping of Japanese AIH patients and showed that the predisposition to type 1 AIH was associated with DRB1*04:05, as well as with DQB1*04:01 (Table 2), which is in strong linkage disequilibrium with DRB1*04:05 [16].…”

Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

“…Among Mestizo Mexicans, HLA-DRB1*0404 is predominant in adult AIH patients [18] . In Japan and Argentina, HLA-DRB1*0405 has been associated with AIH [19,20] while in Brazil, HLA-DRB1*1301 and DRB3*01 are associated with the disease [19,21,22] .…”