MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation

Poncet, Pascal; Arock, Michel; David, B.

doi:10.1002/jlb.66.1.105

Cited by 62 publications

(49 citation statements)

References 49 publications

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“…It has been reported that MCs can process bacterial Ags through a phagocytic route for MHC class I presentation to T cells (11,12) and that human MCs can induce MHC class II-dependent activation of CD4 ϩ T cell hybridomas through superantigen presentation (13,14). We confirmed that MHC class II expression on human MCs was up-regulated in IFN-␥ treatment or Fc⑀RI activation (data not shown).…”

Section: Discussionsupporting

confidence: 81%

“…4). It has been reported that cord blood-derived cultured human MCs express CD80 and that human mast cell lines, HMC-1, express CD40L on their surface (13). However, we found only minimal expression of CD80, CD86, and CD40L on the surface of human MCs by FACS, and Fc⑀RI activation did not up-regulate the expression of these molecules (data not shown).…”

Section: Discussioncontrasting

confidence: 52%

“…Recent studies indicate that MCs can process bacterial Ags through a phagocytic route for MHC class I presentation to T cells (11,12) and that MCs can induce MHC class II-dependent activation of CD4-positive (CD4 ϩ ) T cell hybridomas through superantigen presentation (13,14). A subsequent study has shown that signaling generated by Fc⑀RI provides MCs with IgE-mediated enhanced Ag presentation to T cells (15).…”

Section: Ast Cells (Mcs)mentioning

confidence: 99%

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T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Kashiwakura

Yokoi

Saito

et al. 2004

The Journal of Immunology

150

120

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Mast cells (MCs) are the primary effector cells in allergic reactions and have also been found to activate T cells and to reside in close physical proximity to T cells. However, the molecular mechanisms involved in the MC-T cell interaction remain unclear. We hypothesized that human tonsillar MCs, which locate in the interfollicular areas, might interact with T cells. Thus, we first established a culture system of human tonsillar MCs and then compared gene expression profiles of tonsillar MCs with that of lung MCs before and after aggregation of FcεRI by using high-density oligonucleotide probe arrays. Here we show that resting tonsillar MCs, when compared with lung MCs, revealed significantly higher expression levels for CC chemokines (CCL3 and 4), which recruit T cells, and for TNFR superfamilies (OX40 ligand and 4-1BB ligand), which induce proliferation of T cells. After aggregation of FcεRI, not only tonsillar MCs but also lung MCs up-regulated the expression of these molecules. We confirmed that T cell proliferation is induced in direct cross-talk by the MC surface molecule OX40 ligand. These results suggest that human MCs may play important roles in adaptive immunity through the T cell responses.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 52%

Section: Ast Cells (Mcs)mentioning

confidence: 99%

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T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Kashiwakura

Yokoi

Saito

et al. 2004

The Journal of Immunology

150

120

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“…Mast cells have previously been shown to express another member of the TNF superfamily on the cell membrane, CD30 ligand, that is functional and can activate lymphoma cell lines in vitro [121]. Mast cells can act as antigen-presenting cells to T cells in an MHC class I-and MHC class II-dependent manner in vitro [46,116,160], and human mast cells have been shown to express MHC class II and to present staphylococcal superantigens to CD4 + T cell hybridomas leading to T cell activation [152]. Furthermore, human cord blood-derived mast cells exposed to diVerent gram-negative and gram-positive bacteria in vitro have been shown to bind and phagocytose several bacteria strains, such as Staphylococcus aureus, leading to death of bacteria and TNF-secretion from mast cells [7].…”

Section: Mast Cells In Relation To Cells Of the Immune System In Psormentioning

confidence: 99%

“…Furthermore, human cord blood-derived mast cells exposed to diVerent gram-negative and gram-positive bacteria in vitro have been shown to bind and phagocytose several bacteria strains, such as Staphylococcus aureus, leading to death of bacteria and TNF-secretion from mast cells [7]. In addition to antigen presentation, mouse and human mast cells cultured in vitro have been shown to express CD80 and CD86 that are needed as co-stimulatory signals for eYcient T cell activation [44,152]. In fact, human mast cells express a range of diVerent CD antigens and ICAM-1, VLA-4, Mac-1 and to some extent also LFA-1 [47,77].…”

Section: Mast Cells In Relation To Cells Of the Immune System In Psormentioning

confidence: 99%

Is there a role for mast cells in psoriasis?

et al. 2008

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Mast cells have traditionally been considered as eVector cells in allergy but during the last decade it has been realized that mast cells are essentially involved in the mechanisms of innate and acquired immunity. Upon activation by anaphylactic, piecemeal degranulation or degranulation-independent mechanisms mast cells can secrete rapidly or slowly a number of soluble mediators, such as serine proteinases, histamine, lipid-derived mediators, cytokines, chemokines and growth factors. Mast cells can express cell surface co-stimulatory receptors and ligands, and they can express MHC class II molecules and thereby present antigens. These soluble factors and cell surface molecules can interact with other cells, such as endothelial cells, keratinocytes, sensory nerves, neutrophils, T cell subsets and antigen presenting cells which are essential eVectors in the development of skin inXammation. Besides promoting inXammation, mast cells may attempt in some circumstances to suppress the inXammation and epidermal growth but the regulation between suppressive and proinXammatory mechanisms is unclear. Psoriasis is characterized by epidermal hyperplasia and chronic inXammation where tryptase-and chymase-positive MC TC mast cells are activated early in the developing lesion and later the cells increase in number in the upper dermis with concomitant expression of cytokines and TNF superfamily ligands as well as increased contacts with neuropeptide-containing sensory nerves. Due to the intimate involvement of mast cells in immunity and chronic inXammation the role of mast cells in psoriasis is discussed in this review.

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Communication between human mast cells and CD4⁺T cells through antigen‐dependent interactions

et al. 2013

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Mast cells (MCs) are immune cells residing in tissues where pathogens are first encountered. It has been indicated that MCs might also be involved in setting the outcome of T-cell responses. However, little is known about the capacity of human MCs to express MHC class II and/or to capture and present antigens to CD4(+) T cells. To study the T-cell stimulatory potential of human MCs, CD34(+) stem cell derived MCs were generated. These cells expressed HLA-DR when stimulated with IFN-γ, and, importantly, presented peptide and protein for activation of antigen-specific CD4(+) T cells. The interplay between MC and T cell led to increased HLA-DR expression on MCs. MCs were present in close proximity to T cells in tonsil and expressed HLA-DR and CD80, indicating their ability to present antigens to CD4(+) T cells in T-cell areas of human LNs. Our data show that MCs can present native antigens to human CD4(+) T cells and that HLA-DR expressing MCs are present in tonsil tissue, indicating that human MCs can directly activate T cells and provide a rationale to study the potential of MCs to prime and/or skew human T-cell responses.

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MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation

Cited by 62 publications

References 49 publications

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Is there a role for mast cells in psoriasis?

Communication between human mast cells and CD4⁺T cells through antigen‐dependent interactions

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MHC class II-dependent activation of CD4+ T cell hybridomas by human mast cells through superantigen presentation

Cited by 62 publications

References 49 publications

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

T Cell Proliferation by Direct Cross-Talk between OX40 Ligand on Human Mast Cells and OX40 on Human T Cells: Comparison of Gene Expression Profiles between Human Tonsillar and Lung-Cultured Mast Cells

Is there a role for mast cells in psoriasis?

Communication between human mast cells and CD4+T cells through antigen‐dependent interactions

Contact Info

Product

Resources

About

Communication between human mast cells and CD4⁺T cells through antigen‐dependent interactions