MHC-B haplotypes impact susceptibility and resistance to RSV-A infection

Khare, Vishwa M.; Saxena, V.K.; Tomar, Alka; Singh, Kunal; Tiwari, Anjali

doi:10.2741/e837

Cited by 7 publications

(6 citation statements)

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“…But anchor residue motifs of B have not been studied yet. This result is basically coincident with the findings of Vishwa et al 9 (B21 has less mortality and was resistant to RSV‐A tumor, while B15 susceptibility to RSV‐A tumor) and Hunt et al 10 (B21 has less mortality and was resistant to H5N1 viruses). They concluded that this miscellaneous binding furthers our grasp of modes that BF can present peptides to the T lymphocytes and may account for the resistance of the B21 haplotype to MD.…”

Section: Discussionsupporting

confidence: 90%

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Study on the contrast of the MHC–peptide interaction of B2/B21 haplotype and MHC‐related virus resistance in chickens

Jin

Wang

et al. 2021

Immunity Inflam & Disease

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Introduction Three‐dimensional (3D) structures of MHC class I exert some influence by the MHC–peptide interaction over host resistance to the virus. The thesis aims at studying the connection between MHC–peptide interaction of B2/B21 haplotype and MHC‐related resistance to the virus. Methods The structure of chicken MHC class I BF2*0201 from B2 haplotype was studied and contrasted with that of BF2*2101 from B21 haplotype by using DNAMAN and PyMol software. Results The amino acid difference resulted in the difference in size and changeability of the binding groove of the two, resulting in different choices on the binding polypeptide. 3bew's (the crystal structure of BF2*2101 bound to peptide RV10) small side chain His111 replaces the short side chain Tyr111 of 4cvx (the crystal structure of BF2*0201 bound to peptide YL9), and the very small amino acid of Ser69 and Ser97 make the middle of the 3bew's binding groove become apparently broad and bound restrictive of amino acid smaller. Moreover, due to the specific amino acids—Arg9, Asp24, and Asp73 of 4cvx and Arg9, Asp24, and His111 of 3bew, the effect of the polypeptide and the binding groove differ between the two, and 3bew tends to bind polypeptides with negatively charged amino acids, but the large space in the middle can also accommodate other amino acids. Contrasted with the binding groove characteristic of 4cvx, it can be said that the selectivity of 3bew is higher than that of 4cvx in the amino acid type of the binding polypeptide, so the B21 haplotype has more host resistance to the virus than that of the B2 haplotype in chicken. Conclusion There are usually various kinds of peptides presented by the BF2*2101 molecules of B21 haplotypes, resulting in resistance to pathogenic microorganisms, such as Rous sarcoma virus and/or Marek's disease virus. These findings may have an important theoretical foundation for screening of virus antigen, vaccine design, and genetic resistance breeding.

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Section: Discussionsupporting

confidence: 90%

“…Resistance to lymphomas originating from pathogenic microorganisms, 8 such as MDV and/or RSV 9 and/or avian influenza viruses, 10 has a close connection with the BF in the chicken.…”

Section: Discussionmentioning

confidence: 99%

Study on the contrast of the MHC–peptide interaction of B2/B21 haplotype and MHC‐related virus resistance in chickens

Jin

Wang

et al. 2021

Immunity Inflam & Disease

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“…Furthermore, the detection of ANA or abnormal cryoglobulins might be explained by an altered function of suppressor T cells and by proliferation of monoclonal B lymphoid cells ( 19 , 20 ). Finally, diversity of the major histocompatibility complex and innate immune gene expression have a significant positive correlation with resistance or susceptibility to various types of cancers ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

Vascular Acrosyndromes Associated With Prolonged Tumor Response in Advanced Lung Cancer Patients During Treatment With Antimetabolites: A Report of Two Cases

et al. 2021

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BackgroundPemetrexed and gemcitabine are both antimetabolites drugs approved in advanced non-small cell lung cancer (NSCLC). Their toxicity profile is well known. However, rare vascular side effects can occur such as vascular acrosyndromes and especially digital ischemia. The cause of this disfiguring and painful event is still controversial. Amputation is frequently required and has been described as a predictor of poor survival outcomes.Case PresentationThis report presents two cases of vascular acrosyndrome in NSCLC patients during treatment with antimetabolites (pemetrexed and gemcitabine). Patients presented severe digital ischemia having required prostacyclin analog and chemotherapy discontinuation. In one case, symptoms improved while in the other case symptoms persisted. Both patients experienced prolonged tumor response. These findings suggest a multifactorial mechanism behind digital necrosis including an autoimmune process, which could lead to prolonged tumor control as described with immune checkpoint inhibitors.ConclusionSevere vascular acrosyndrome such as digital ischemia can occur in lung cancer patients treated with antimetabolites. Awareness needs to be raised when using these drugs in patients with predisposing factors. Whether occurrence of chemotherapy-induced immune vascular side effects might explain prolonged tumor response deserves further investigations.

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“…(1) Proteins are represented in different forms such as receptors, enzymes, ion channels, transporters, regulatory proteins (Alexander et al, 2019a;Alexander et al, 2019b;Alexander et al, 2019c;Alexander et al, 2019d;Alexander et al, 2019e;Alexander et al, 2019f;Alexander et al, 2019g), cytokines, chemokines (Khare et al, 2019), structural proteins, cytoskeletal proteins, microtubules forming the mitotic spindle, transcription factors, and hormones. MHC-B complex genes that encode for cell surface proteins, are activated and affect the tumor outcome (Khare et al, 2018). It has been reported that most SM apparently interact with proteins and change the protein conformation in an unselective manner (binding, complexing, and denaturing).…”

Section: Major Cellular Targets For Secondary Metabolitesmentioning

confidence: 99%

Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

et al. 2021

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Plant secondary metabolites (SMs) common natural occurrences and the significantly lower toxicities of many SM have led to the approaching development and use of these compounds as effective pharmaceutical agents; especially in cancer therapy. A combination of two or three of plant secondary metabolites together or of one SM with specific anticancer drugs, may synergistically decrease the doses needed, widen the chemotherapeutic window, mediate more effective cell growth inhibition, and avoid the side effects of high drug concentrations. In mixtures they can exert additive or even synergistic activities. Many SM can effectively increase the sensitivity of cancer cells to chemotherapy. In phytotherapy, secondary metabolites (SM) of medicinal plants can interact with single or multiple targets. The multi-molecular mechanisms of plant secondary metabolites to overcome multidrug resistance (MDR) are highlighted in this review. These mechanisms include interaction with membrane proteins such as P-glycoprotein (P-gp/MDR1); an ATP-binding cassette (ABC) transporter, nucleic acids (DNA, RNA), and induction of apoptosis. P-gp plays an important role in the development of MDR in cancer cells and is involved in potential chemotherapy failure. Therefore, the ingestion of dietary supplements, food or beverages containing secondary metabolites e.g., polyphenols or terpenoids may alter the bioavailability, therapeutic efficacy and safety of the drugs that are P-gp substrates.

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MHC-B haplotypes impact susceptibility and resistance to RSV-A infection

Cited by 7 publications

References 0 publications

Study on the contrast of the MHC–peptide interaction of B2/B21 haplotype and MHC‐related virus resistance in chickens

Study on the contrast of the MHC–peptide interaction of B2/B21 haplotype and MHC‐related virus resistance in chickens

Vascular Acrosyndromes Associated With Prolonged Tumor Response in Advanced Lung Cancer Patients During Treatment With Antimetabolites: A Report of Two Cases

Multiple Molecular Mechanisms to Overcome Multidrug Resistance in Cancer by Natural Secondary Metabolites

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