2007
DOI: 10.1172/jci30966
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MFG-E8–mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF

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Cited by 183 publications
(236 citation statements)
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“…Tim3 pathway inhibition reduces phagocytosis of apoptotic cells and induces autoantibody production, indicating the break of peripheral tolerance [12]. In concordance with this, the efficacy of a therapeutic vaccine for melanoma is significantly augmented when the phagocytosis of apoptotic cells is inhibited by the binding of milk fat globule epidermal growth factor 8 to phosphatidylserine [34].…”
Section: Discussionmentioning
confidence: 65%
“…Tim3 pathway inhibition reduces phagocytosis of apoptotic cells and induces autoantibody production, indicating the break of peripheral tolerance [12]. In concordance with this, the efficacy of a therapeutic vaccine for melanoma is significantly augmented when the phagocytosis of apoptotic cells is inhibited by the binding of milk fat globule epidermal growth factor 8 to phosphatidylserine [34].…”
Section: Discussionmentioning
confidence: 65%
“…Tregs dampen the activity of effector T cells, and thus prevent excessive immune reactions, such as autoimmunity, but they can also prevent efficient immune responses, especially in the context of tumors. Two recent articles have proposed a regulatory T cell-promoting role for Mfge8/lactadherin in mice: in atherosclerosis (Ait-Oufella et al, 2007), or in granulocyte monocyte-colony stimulating factor-dependent induction of anti-tumor immune responses (Jinushi et al, 2007). More recently, the latter group has shown that subcutaneous grafts of mouse melanoma cells transfected with Mfge8 were infiltrated with Mfge8-expressing macrophages, regulatory T cells, and poorly efficient cytotoxic T cells when transplanted in mice (Jinushi et al, 2008), and thus became more aggressive.…”
Section: Discussionmentioning
confidence: 99%
“…BCG instillation has been proposed to overcome the tolerance established in the tumor, and switch the immune system towards effective antitumor activity (Saint et al, 2001). Jinushi et al (Jinushi et al, 2007) have shown that, in the presence of pathogen-derived ligands and/or necrotic cells, phagocytosis of tumor cells by macrophages is performed in the absence of Mfge8 and results in effective anti-tumor immune responses, whereas in the absence of these stress conditions, the same phagocytosis performed through Mfge8 induces tolerogenic immune responses. As any bacteria, BCG bears pathogen ligands, and its instillation probably creates the stress conditions proposed to favor effector immune responses.…”
Section: Discussionmentioning
confidence: 99%
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