2010
DOI: 10.1038/onc.2010.446
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Milk fat globule—epidermal growth factor—factor VIII (MFGE8)/lactadherin promotes bladder tumor development

Abstract: Milk fat globule-epidermal growth factor-factor VIII (MFGE8), also called lactadherin or SED1, is a secreted integrin-binding protein that promotes elimination of apoptotic cells by phagocytes leading to tolerogenic immune responses, and vascular endothelial growth factor (VEGF)-induced angiogenesis: two important processes for cancer development. Here, by transcriptomic analysis of 228 biopsies of bladder carcinomas, we observed overexpression of MFGE8 during tumor development, correlated with expression of g… Show more

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Cited by 51 publications
(53 citation statements)
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“…(B) In vivo serial tumor passages were performed to evaluate the frequency of CSCs. TAM from wild-type or MFG-E8-deficient mice was injected along with MC38-CSCs s.c. into MFG-E8-deficient mice (n = 4 per group) at 1 × immune-dependent mechanisms (10,11,23). In this study, we have identified that MFG-E8, mainly derived from CSC-associated macrophages, is a major contributor in triggering the tumorigenicity and resistance to anticancer drugs of CSCs.…”
Section: Discussionmentioning
confidence: 86%
See 1 more Smart Citation
“…(B) In vivo serial tumor passages were performed to evaluate the frequency of CSCs. TAM from wild-type or MFG-E8-deficient mice was injected along with MC38-CSCs s.c. into MFG-E8-deficient mice (n = 4 per group) at 1 × immune-dependent mechanisms (10,11,23). In this study, we have identified that MFG-E8, mainly derived from CSC-associated macrophages, is a major contributor in triggering the tumorigenicity and resistance to anticancer drugs of CSCs.…”
Section: Discussionmentioning
confidence: 86%
“…Although MFG-E8 has been reported to accelerate tumorigenicity of certain spontaneously arising tumors (23), it remains unknown whether MFG-E8 modulates CSC functions. Thus, MC38-CSCs or 3LL-CSCs were inoculated into MFG-E8-deficient mice or their wild-type counterparts, and the CSC frequencies in established tumors were evaluated by measuring CSC-specific marker expression 1 mo after in vivo tumor challenge.…”
Section: Tam-specific Mfg-e8 Renders Cscs With the Ability To Promotementioning
confidence: 99%
“…14 Angiogenic endothelial cells in and around the tumor have MFG-E8-dependent phagocytic properties for apoptotic cells or aged erythrocytes. 15 In addition to phagocytotic events, the MFG-E8 expressions are also known to be upregulated in neoplastic conditions, including breast cancer, 1,16,17 malignant melanoma, 18,19 bladder tumors, 20 and ovarian cancer. 21 The MFG-E8 expression has been correlated to their progressions [18][19][20] and to poor clinical outcome.…”
mentioning
confidence: 99%
“…15 In addition to phagocytotic events, the MFG-E8 expressions are also known to be upregulated in neoplastic conditions, including breast cancer, 1,16,17 malignant melanoma, 18,19 bladder tumors, 20 and ovarian cancer. 21 The MFG-E8 expression has been correlated to their progressions [18][19][20] and to poor clinical outcome. 19 Regarding neoplasms of keratinocytic origin, MFG-E8 has been demonstrated in experimentally induced skin tumors in mice, in which the reduced expression of MFG-E8 was correlated with cellular differentiation.…”
mentioning
confidence: 99%
“…This problem will soon be overcome by the design of non-invasive diagnostic equipment for small animals, similar to those used in medical practice in humans, such as ultrasound-doppler, infrared (IR) or bioluminescence imaging. By way of example, ultrasound-Doppler sagittal images have been used to evaluate angiogenesis in a mouse bladder cancer model (Sugano et al, 2011). Also, bladder cancer cells that have been engineered to express certain proteins that emit fluorescence are being used in bioluminescence detection of tumor development (Black et al, 2010).…”
Section: Orthotopic Tumor Growthmentioning
confidence: 99%