Mezcla lipídica para mejorar el desarrollo psicomotriz en niños menores de 5 años con parálisis cerebral infantil

Soldán, Ricardo Sevilla Paz; Bustillos, Rocio Condori; Claros, Alfredo Sejas; Mexicano, Raúl Huayhua; Domaire, Paula Calla

doi:10.51581/rccm.v21i2.70

Rev Cient Cien Med

2018

DOI: 10.51581/rccm.v21i2.70

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Mezcla lipídica para mejorar el desarrollo psicomotriz en niños menores de 5 años con parálisis cerebral infantil

Ricardo Sevilla Paz Soldán

Rocio Condori Bustillos²,

Alfredo Sejas Claros³

et al.

Abstract: Introducción: La Parálisis Cerebral Infantil constituye un grupo de patologías neurológicas invalidantes que requieren un manejo multidisciplinario. La neurofuncionalidad y neuroplasticidad son elementos esenciales para comprender procesos de aprendizaje y rehabilitación de funciones tras una alteración neurológica, como la recuperación del retardo en el desarrollo psicomotor. Objetivo: Valorar el efecto de una mezcla lipídica en niños con parálisis cerebral infantil y determinar cambios en su desarrollo psico… Show more

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Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review

Rebelo

Mansur²,

Miglioli³

et al. 2022

PLoS ONE

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Background Cerebral palsy is an extremely severe brain injury associated with multiple nutritional and clinical issues, such as underweight, gastroesophageal reflux, constipation, and nutrient deficiency. Evidence-based dietary and nutritional interventions may improve the quality of life of children with cerebral palsy. Aim Systematically review randomized clinical trials evaluating nutritional and dietary interventions in the clinical, nutritional, and neurodevelopmental aspects of children with cerebral palsy. Methods A search was performed in electronic databases (LILACS, Medline, Web of Science, Embase, Scopus, Cochrane Library, ClinicalTrials.gov, Brazilian Digital Library of Theses and Dissertations, ProQuest Dissertations and Theses Database, OpenGrey) using keywords. The search was firstly performed in May 2020 and updated on June 18th, 2021. Eligible studies were randomized clinical trials, that included children between 2 and 12 years old, and evaluated the effect of nutritional or dietetic interventions on clinical, nutritional or neurodevelopmental outcomes. Risk of bias was investigated using the RoB-2 tool. The study was registered on PROSPERO (CRD42020181284). Results Fifteen studies were selected. Positive results included the use of whey-based or pectin-enriched enteral formulas for gastroesophageal reflux (n = 6); 25-hydroxy-vitamin D supplementation for hypovitaminosis D (n = 2); supplementation with lipid mixture or diet with high-density energy for improvements in anthropometric measures (n = 2); supplementation with probiotics, prebiotics, symbiotics or magnesium for constipation (n = 2); nutritional support system for gross motor function (n = 1); lactoferrin and iron hydroxide polymaltose for iron deficiency anemia (n = 1); and educational intervention to improve feeding skills (n = 1). The overall risk of bias was high for 60% of the studies, and some concerns were raised for the remaining 40%. Conclusion Some promising dietary and nutritional interventions may promote important clinical improvements for patients with cerebral palsy. However, evidence is weak, as few clinical trials have been published with many methodological errors, leading to a high risk of bias.

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Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review

Rebelo

Mansur²,

Miglioli³

et al. 2022

PLoS ONE

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Nutritional Support System (NSS) as a New Therapeutic Strategy for Cerebral Palsy

Leal-Martínez

Jimenez-Ramirez

Ibarra

2024

CNSNDDT

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Cerebral palsy (CP) is part of a group of nonprogressive motor disorders. The disease affects movement and posture and constitutes the most frequent cause of motor disability in childhood. CP is characterized by spasticity, reflecting lesions in the pyramidal pathway. Treatment is currently focused on physical rehabilitation, and the annual progression of the disease is 2-3%. About 60% of these patients present severe degrees of malnutrition associated with dysphagia, gastrointestinal abnormalities, malabsorption, increased metabolism, and depression. These alterations promote sarcopenia functional dependence and affect the quality of life and delay the evolution of motor skills. Currently, there is evidence that the supplementation of several nutrients, dietary correction, and probiotics can improve neurological response by stimulating neuroplasticity, neuroregeneration, neurogenesis, and myelination. This therapeutic strategy could shorten the response period to treatment and increase both gross and fine motor skills. The interaction of nutrients and functional foods integrating a Nutritional Support System (NSS) has shown greater efficiency in neurological stimulation than when nutrients are supplied separately. The most studied elements in the neurological response are glutamine, arginine, zinc, selenium, cholecalciferol, nicotinic acid, thiamine, pyridoxine, folate, cobalamin, Spirulina, omega-3 fatty acids, ascorbic acid, glycine, tryptophan, and probiotics. The NSS represents a therapeutic alternative that will restore neurological function in patients with spasticity and pyramidal pathway lesions, both characteristics of patients with CP.

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Mezcla lipídica para mejorar el desarrollo psicomotriz en niños menores de 5 años con parálisis cerebral infantil

Cited by 2 publications

References 7 publications

Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review

Dietary and nutritional interventions in children with cerebral palsy: A systematic literature review

Nutritional Support System (NSS) as a New Therapeutic Strategy for Cerebral Palsy

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