METS-IR, a novel score to evaluate insulin sensitivity, is predictive of visceral adiposity and incident type 2 diabetes

Bello‐Chavolla, Omar Yaxmehen; Almeda‐Valdés, Paloma; Gómez‐Velasco, Donají; Viveros-Ruiz, Tannia Leticia; Cruz-Bautista, Ivette; Romo-Romo, Alonso; Sánchez-Lázaro, Daniel; Meza-Oviedo, Dushan; Vargas‐Vázquez, Arsenio; Campos, Olimpia Arellano; Sevilla-González, Magdalena del Rocío; Martagón, Alexandro J.; Hernández, Liliana; Mehta, Roopa; Caballeros-Barragán, César Rodolfo; Aguilar-Salinas, Carlos A.

doi:10.1530/eje-17-0883

Cited by 194 publications

(263 citation statements)

References 41 publications

(53 reference statements)

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“…WC divided by HC was the waist‐to‐hip ratio (WHR), and WC divided by height was the waist‐to‐height ratio (WHtR) . Non‐insulin‐based IR indexes were calculated by the following formulas: TyG = Ln [fasting TG (mg/dL)*FPG (mg/dL)/2]; TG/HDLc = TG divided by HDLc; METS‐IR = Ln [(2*FPG) + TG]*BMI)/(Ln[HDLc]) …”

Section: Methodsmentioning

confidence: 99%

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

Liu¹,

Fan

Pan³

2019

J of Clinical Hypertension

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Insulin resistance (IR) plays a crucial role in the development of hypertension, so early recognition of IR is of substantial clinical importance for the management of hypertension. But traditional IR indexes are invasive, complex, and impractical. We aimed to evaluate the associations between three simple IR indexes and hypertension in different body mass index (BMI) categories. A total of 142 005 adults who did not take antihypertensive medication were included in this analysis. The ratio of triglycerides to high‐density lipoprotein cholesterol (TG/HDLc), the product of fasting triglycerides and glucose (TyG), and metabolic score for IR (METS‐IR) were calculated according to the corresponding formulas. The associations between them and hypertension were analyzed by logistic regression. Among the three indicators, only METS‐IR had positive correlations with blood pressure levels (all P < 0.001). After full adjustment, METS‐IR was significantly associated with hypertension in the normal BMI group but not in the elevated BMI group. The OR for hypertension in the normal BMI group in the highest quartile of METS‐IR was 2.884 (95% CI: 2.468‐3.369) in the total sample, 1.915 (95% CI: 1.614‐2.271) in females and 2.083 (95% CI: 1.717‐2.527) in males. Our findings indicate that METS‐IR, a simple and cost‐effective IR index, was strongly associated with hypertension in normal‐weight Chinese subjects. It could help monitor and manage hypertension in normal‐weight individuals.

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Section: Methodsmentioning

confidence: 99%

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

Liu¹,

Fan

Pan³

2019

J of Clinical Hypertension

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“…Furthermore, the plasma concentration ratio of TG/HDL, TG divided by high‐density lipoprotein cholesterol (HDL‐C), has been suggested as a useful surrogate index of insulin action . In addition, the metabolic score for IR (METS‐IR) has been reported as a novel index for the evaluation of cardiometabolic risk in healthy and at‐risk individuals, and as a promising tool for screening insulin sensitivity …”

Section: Introductionmentioning

confidence: 99%

Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study

Wang

Zhang

et al. 2018

J of Diabetes Invest

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Aims/Introduction Metabolic unhealth can be defined by the components of metabolic syndrome, which is closely connected to insulin resistance. We aimed to determine a simple index to identify metabolic unhealth in the Chinese adult population. Materials and Methods A total of 30,291 individuals were screened from the China National Diabetes and Metabolic Disorders Study carried out from June 2007 to May 2008. Metabolic unhealth was defined using components of metabolic syndrome, except waist circumference. We compared the three surrogate indices of insulin resistance : the product of fasting triglycerides and glucose (TyG), triglycerides divided by high‐density lipoprotein cholesterol and the metabolic score for insulin resistance for the evaluation of metabolic status. Results All indices had high sensitivity and specificity for the identification of metabolic unhealth, especially the TyG index with an area under the curve of 0.863 for men and 0.867 for women. Participants were divided into subgroups for further analysis. The TyG index also showed high diagnostic values, especially for younger individuals and men with normal waist circumference . Sex‐specific cut‐offs for three indices were also used to define metabolic unhealth. The TyG index showed the highest agreement with κ values of 0.603 and 0.605 for men and women between the components of metabolic syndrome and three indices. Conclusions We propose that the TyG index, just read in one blood laboratory test report, is simpler and more suitable for the identification of metabolically unhealthy individuals as well as who have high risk of cardiometabolic diseases of the Chinese adult population.

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“…9,10 The recently developed Metabolic Score for IR (METS-IR) offers higher concordance with EHC compared with other non-insulin-based IR indexes; furthermore, METS-IR includes evaluation of body mass index (BMI), which has shown strong predictive capacity for CVD risk. 11,12 Overall, METS-IR evaluates similar components to the metabolic syndrome (MS), which has been associated with agerelated structural and functional changes in arteries and increased intima-media thickness, which confers an increased risk of hypertension and CVD. 13 Here, we aimed to investigate the correlation of METS-IR with pulse wave velocity (PWV) and other vascular health surrogates from PWV analysis.…”

Section: Introductionmentioning

confidence: 99%

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

Bello‐Chavolla

Antonio-Villa

Vargas‐Vázquez

et al. 2019

J of Clinical Hypertension

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Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non–insulin‐based IR indexes were developed as tools for metabolic screening. Here, we aimed to evaluate the novel non–insulin‐based Metabolic Score for IR (METS‐IR) index for the prediction of incident hypertension and arterial stiffness evaluated using pulse wave velocity (PWV) analysis, compared with other non–insulin‐based IR indexes. We evaluated two populations, a cross‐sectional evaluation of high‐risk individuals (n = 305) with a wide range of metabolic comorbidities and dyslipidemia in whom PWV measurement was performed and a 3‐year prospective cohort of normotensive individuals (N = 6850). We observed a positive correlation between METS‐IR and PWV in the cross‐sectional cohort, which was higher compared with other non–insulin‐based fasting IR indexes; furthermore, PWV values >75th percentile were associated with the upper tercile of METS‐IR values. In the prospective cohort, we observed an increased risk for incident hypertension for the upper METS‐IR tercile (METS‐IR ≥ 46.42; HR: 1.81, 95% CI: 1.41‐2.34), adjusted for known cardiovascular risk factors, and observed that METS‐IR had greater increases in the predictive capacity for hypertension along with SBP and the Framingham Hypertension Risk Prediction Model compared with other non–insulin‐based IR indexes. Therefore, METS‐IR is a novel non–insulin‐based IR index which correlates with arterial stiffness and is a predictor of incident hypertension, complementary to previously validated risk prediction models.

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METS-IR, a novel score to evaluate insulin sensitivity, is predictive of visceral adiposity and incident type 2 diabetes

Abstract: METS-IR is a novel score to evaluate cardiometabolic risk in healthy and at-risk subjects and a promising tool for screening of insulin sensitivity.

Cited by 194 publications

References 41 publications

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

METS‐IR, a novel simple insulin resistance indexes, is associated with hypertension in normal‐weight Chinese adults

Fasting triglycerides and glucose index is more suitable for the identification of metabolically unhealthy individuals in the Chinese adult population: A nationwide study

Prediction of incident hypertension and arterial stiffness using the non–insulin‐based metabolic score for insulin resistance (METS‐IR) index

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