2020
DOI: 10.1016/j.cmi.2019.05.022
|View full text |Cite
|
Sign up to set email alerts
|

Metronidazole-sensitive organisms in children with severe acute malnutrition: an evaluation of the indication for empiric metronidazole treatment

Abstract: a b s t r a c tObjectives: Children with severe acute malnutrition (SAM) are treated with empiric amoxicillin or penicillin and gentamicin because of the high risk of severe infections. Experts have suggested, based on available evidence, adding metronidazole to cover anaerobic bacteraemia and diarrhoea caused by Giardia duodenalis or Clostridium difficile. The objective of this study was to assess the importance of these infections in children with SAM. Methods: Children from 6 months to 15 years with SAM wer… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4
1

Citation Types

0
10
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(10 citation statements)
references
References 27 publications
(33 reference statements)
0
10
0
Order By: Relevance
“…Fifteen studies had a high risk of bias because the samples were not representative of the target population (eg, special populations) (eTable 3 in the Supplement). Most studies had either low (n = 88) or unclear (n = 5) risk of bias with regard to participant recruitment.…”
Section: Resultsmentioning
confidence: 87%
See 3 more Smart Citations
“…Fifteen studies had a high risk of bias because the samples were not representative of the target population (eg, special populations) (eTable 3 in the Supplement). Most studies had either low (n = 88) or unclear (n = 5) risk of bias with regard to participant recruitment.…”
Section: Resultsmentioning
confidence: 87%
“…Age groups included neonates (n = 13); infants (n = 24); and children 2 years or younger (n = 12), 3 years or younger (n = 3), 5 years or younger (n = 2), 8 years or younger (n = 2), 10 years or younger (n = 1), and older than 10 years (n = 32) . Seventy-seven studies included healthy children; other populations were premature or low-birth-weight infants (n = 6), patients with oncologic or hematologic disease (n = 9), patients with a diagnosis of malnourishment (n = 1), and outpatients attending gastroenterology clinics without C difficile –associated clinical symptoms (n = 2) (eTable 2 in the Supplement).…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…One EDTA plasma tube (Vacuette, Becton Dickinson (BD), Austria) and, if the child was not admitted to intensive care, one Serum Sep Clot tube (Vacuette, BD, Austria) were obtained. Furthermore, blood cultures were performed using aerobic and anaerobic blood culture vials (BACTEC Peds Plus and BACTEC Lytic/10 Anaerobic, BD, USA) as previously described .…”
Section: Methodsmentioning
confidence: 99%