Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy

Wilson, Erik B.; Bass, Cyndi; Abrameit, Warren; Roberson, Richard; Smith, Randall W.

doi:10.1016/s0002-9610(00)00574-2

Cited by 52 publications

(35 citation statements)

References 10 publications

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“…Meta-analysis of new double-blind RCTs comparing metoclopramide (10 mg) with placebo controls report no statistically significant differences in nausea and vomiting in the immediate postoperative period (Category A1-E evidence), but indicate efficacy in the reduction of vomiting during the first 24-h postoperative period (Category A1-B evidence). 14,18,23,[41][42][43][44] Statistically significant differences were reported in the original Guidelines for nausea and vomiting without indicating time of measurement (Category A1-B evidence). Scopolamine.…”

Section: A1-e Evidence)mentioning

confidence: 99%

Practice Guidelines for Postanesthetic Care

et al. 2013

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Section: A1-e Evidence)mentioning

confidence: 99%

Practice Guidelines for Postanesthetic Care

et al. 2013

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“…The incidence of postoperative nausea and vomiting after laparoscopic procedures ranges from 10 to 60% [81,201,312]. After laparoscopic cholecystectomy, nausea and vomiting persisted up to 14 days in some patients [296].…”

Section: Pain Nausea and Vomitingmentioning

confidence: 99%

The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery

et al. 2002

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Preoperatively, all patients should be assessed for the presence of cardiac, pulmonary, hepatic, renal, or vascular comorbidity. Presupposing appropriate perioperative measures and surgical technique, there is no reason to contraindicate pneumoperitoneum in patients with peritonitis or intraabdominal malignancy. During laparoscopy, monitoring of end tidal CO2 concentration is mandatory. The available data on closed- (Veress needle) and open-access techniques do not allow us to principally favor the use of either technique. Using 2 to 5-mm instead of 5 to 10-mm trocars improves cosmetic result and postoperative pain marginally. It is recommended to use the lowest intraabdominal pressure allowing adequate exposure of the operative field, rather than using a routine pressure. In patients with limited cardiac, pulmonary, or renal function, abdominal wall lifting combined with low-pressure pneumoperitoneum might be an alternative. Abdominal wall lifting devices have no clinically relevant advantages compared to low-pressure (5-7 mmHg) pneumoperitoneum. In patients with cardiopulmonary diseases, intra- and postoperative arterial blood gas monitoring is recommended. The clinical benefits of warmed, humidified insufflation gas are minor and contradictory. Intraoperative sequential intermittent pneumatic compression of the lower extremities is recommended for all prolonged laparoscopic procedures. For the prevention of postoperative pain a wide range of treatment options exists. Although all these options seem to reduce pain, the data currently do not justify a general recommendation.

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“…Prophylactic IV administration of metoclopramide 10-20 mg reduces the incidence of PONV after LC and is as effective as ondansetron 4-8 mg [38,39]. Higher doses ([0.2 mg/kg) of metoclopramide is associated with extrapyramidal reactions such as akathisia and motor restlessness [7,8].…”

Section: Improved Antiemetic Prophylaxismentioning

confidence: 99%

RETRACTED ARTICLE: Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy

Fujii

2010

Surg Endosc

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The common and distressing complications of postoperative nausea and vomiting (PONV) are the main concern of 40-70% of patients undergoing laparoscopic cholecystectomy (LC). The first step in preventing PONV after LC is to reduce the risk factors involving patient characteristics, surgical procedure, anesthetic technique, and postoperative care. Particularly, the use of propofol-based anesthesia can reduce the incidence of PONV after LC. Second, prophylactic antiemetics including antihistamines (dimenhydrinate), phenothiazines (perphenazine), butyrophenones (droperidol), benzamides (metoclopramide), dexamethasone, and serotonin receptor antagonists (ondansetron, granisetron, tropisetron, dolasetron, and ramosetron) are available for preventing PONV after LC. Third, antiemetic therapy combined with a serotonin receptor antagonist (ondansetron, granisetron) and droperidol or dexamethasone is highly effective in the prevention of PONV after LC. Fourth, acupressure at the P6 point is a nonpharmacologic technique that is as effective as ondansetron for preventing PONV after LC. Knowledge regarding the risk factors for PONV and antiemetics is needed for the management of PONV after LC.

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Metoclopramide versus ondansetron in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy

Cited by 52 publications

References 10 publications

Practice Guidelines for Postanesthetic Care

Practice Guidelines for Postanesthetic Care

The European Association for Endoscopic Surgery clinical practice guideline on the pneumoperitoneum for laparoscopic surgery

RETRACTED ARTICLE: Management of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy

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