Metoclopramide Increases Plasma but Not Cerebrospinal Fluid Vasopressin Levels in Man: Study in Hydrocephalic Patients

Barreca, T; Franceschini, R.; Siani, C; Cataldi, A.; Francaviglia, Natale; Silvestro, C; Rolandi, E

doi:10.1159/000181912

Cited by 3 publications

(2 citation statements)

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“…Dehydration reduces physical work capacity, lowers tolerance to heat, and remains a significant health risk [3]. Assessment of dehydration still relies heavily on body fluid chemistry, which is impractical in many athletic or occupational settings.…”

Section: Discussionmentioning

confidence: 99%

“…A loss of total body water (TBW) equivalent or greater than 2% of body mass can significantly reduce performance on prolonged submaximal tasks [2,3] and impaired muscular strength and power [4]. Interestingly, the extent of water loss from specific tissue compartments including the skeletal muscle is not well understood and may depend on the means through which dehydration is induced.…”

Section: Introductionmentioning

confidence: 99%

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Skeletal muscle volume following dehydration induced by exercise in heat

et al. 2012

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BackgroundIntracellular skeletal muscle water is redistributed into the extracellular compartment during periods of dehydration, suggesting an associated decline in muscle volume. The purpose of this study was to evaluate skeletal muscle volume in active (knee extensors (KE)) and less active (biceps/triceps brachii, deltoid) musculature following dehydration induced by exercise in heat.MethodsTwelve participants (seven men, five women) cycled in the heat under two conditions: (1) dehydration (DHYD) resulting in 3% and 5% losses of estimated total body water (ETBW), which was assessed by changes in body mass, and (2) fluid replacement (FR) where 3% and 5% losses of ETBW were counteracted by intermittent (20 to 30 min) fluid ingestion via a carbohydrate-electrolyte beverage. During both conditions, serum osmolality and skeletal muscle volume (assessed by magnetic resonance imaging) were measured at baseline and at the 3% and 5% ETBW loss measurement points.ResultsIn DHYD, serum osmolality increased at 3% (p = 0.005) and 5% (p < 0.001) ETBW losses, while FR decreased serum osmolality at the 5% loss of ETBW time point (p = 0.009). In DHYD, KE muscle volume declined from 1,464 ± 446 ml to 1,406 ± 425 ml (3.9%, p < 0.001) at 3% ETBW loss and to 1,378 ± 421 ml (5.9%, p < 0.001) at 5% ETBW loss. The largest decline in KE volume in DYHD occurred in the mid-belly (31 ml, p = 0.001) and proximal (24 ml, p = 0.001) regions of the grouped vasti muscles. There were no changes in volume for the biceps/triceps (p = 0.35) or deltoid (p = 0.92) during DHYD. FR prevented the loss of KE muscle volume at 3% (1,430 ± 435 ml, p = 0.074) and 5% (1,431 ± 439 ml, p = 0.156) ETBW loss time points compared to baseline (1,445 ± 436 ml).ConclusionsFollowing exercise in the heat, the actively contracting muscles lost volume, while replacing lost fluids intermittently during exercise in heat prevented this decline. These results support the use of muscle volume as a marker of water loss.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%