Metoclopramide for breast milk production

Toppare, Mete F.; Lâleli, Yahya; Senses, Dursun Alí; Kitapci, Füsun; Kaya, İlyas; Dilmen, Uğur

doi:10.1016/s0271-5317(05)80256-8

Cited by 21 publications

(12 citation statements)

References 32 publications

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“…of Action: Metoclopramide antagonizes the release of dopamine in the central nervous system (CNS), thereby, increases PRL levels (4,(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Mechanismmentioning

confidence: 99%

Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production

Zuppa¹,

Sindico²,

Orchi³

et al. 2010

J Pharm Pharm Sci

165

168

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Poor production of breast milk is the most frequent cause of breast lactation failure. Often, physician prescribe medications or other substances to solve this problem. The use of galactogogues should be limited to those situations in which reduced milk production from treatable causes has been excluded. One of the most frequent indication for the use of galactogogues is the diminution of milk production in mothers using indirect lactation, particularly in the case of preterm birth. The objective of this review is to analyze to the literature relating to the principal drugs used as galactogogues (metoclopramide, domperidone, chlorpromazine, sulpiride, oxytocin, growth hormone, thyrotrophin releasing hormone, medroxyprogesterone). Have been also analyzed galactogogues based on herbs and other natural substances (fenugreek, galega and milk thistle). We have evaluated their mechanism of action, transfer to maternal milk, effectiveness and potential side effects for mother and infant, suggested doses for galactogogic effect, and recommendation for breastfeeding.

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Section: Mechanismmentioning

confidence: 99%

Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production

Zuppa¹,

Sindico²,

Orchi³

et al. 2010

J Pharm Pharm Sci

165

168

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“…12 A number of older studies documented increased baseline prolactin levels in lactating women who took metoclopramide or domperidone. [15][16][17][18][19][20] However, there are only a few randomized, placebo-controlled, blinded studies on each of these agents, and these studies are small.…”

Section: Pharmaceutical Galactogoguesmentioning

confidence: 99%

ABM Clinical Protocol #9: Use of Galactogogues in Initiating or Augmenting the Rate of Maternal Milk Secretion (First Revision January 2011)

Medici¹

2011

Breastfeeding Medicine

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A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breastfeeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. These guidelines are not intended to be all-inclusive, but to provide a basic framework for physician education regarding breastfeeding.

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“…[78][79][80] These dopamine inhibiting agents work by stimulating the release of prolactin from the anterior pituitary gland, thus increasing lactation in women with inadequate or decreased milk production. 81 The safety and efficacy of exposure to galactogogues in preterm infants has not been well established.…”

Section: Maintaining a Milk Supplymentioning

confidence: 99%

A Review of the Literature Examining the Benefits and Challenges, Incidence and Duration, and Barriers to Breastfeeding in Preterm Infants

Callen¹,

Pinelli

2005

Advances in Neonatal Care

190

177

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Breastfeeding benefits preterm infants from a nutritional, gastrointestinal, immunological, developmental, and psychological perspective. Despite the benefits, the incidence and duration of breastfeeding preterm infants continues to be less than that of full-term infants. The lower incidence is probably related to breastfeeding challenges that preterm infants and parents face, including establishing and maintaining a milk supply and transitioning from gavage feeding to breastfeeding. In order to increase the incidence and duration of breastfeeding preterm infants, researchers must examine breastfeeding experiences longitudinally. This way, researchers and clinicians can begin to understand the barriers to breastfeeding at various time periods in the breastfeeding experience and begin implementing strategies to remove these barriers.

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Metoclopramide for breast milk production

Cited by 21 publications

References 32 publications

Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production

Safety and Efficacy of Galactogogues: Substances that Induce, Maintain and Increase Breast Milk Production

ABM Clinical Protocol #9: Use of Galactogogues in Initiating or Augmenting the Rate of Maternal Milk Secretion (First Revision January 2011)

A Review of the Literature Examining the Benefits and Challenges, Incidence and Duration, and Barriers to Breastfeeding in Preterm Infants

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