Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats

Harputluoğlu, Murat Muhsin Muhip; Temel, İsmail; Demirel, Ulvi; Seçkin, Yüksel; Aladağ, Murat; Otlu, Barış; Karadağ, Neşe; Özyalın, Fatma; Aydoğan, Nilay; Selçuk, Engin Burak

doi:10.5152/tjg.2017.1775

Cited by 2 publications

(2 citation statements)

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“…This might be due to severe tissue oedema, necrosis, goblet cell hyperplasia, and inflammatory cell infiltration. Further, the macroscopic study of the intestinal content of animal treated with extract of Centella asiatica and Murraya koenigii showed that they had reduced leucocyte infiltration, dramatically attenuated histopathological alterations, and exerted anti-inflammatory and anticolitic effects 18 . The extract inhibited the excessive loss of blood, which indicated the therapeutic success of potential antiulcerative agents 19 .…”

Section: Discussionmentioning

confidence: 99%

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2022

IJPSR

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Section: Discussionmentioning

confidence: 99%

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2022

IJPSR

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“…TAA (Sigma‐Aldrich, St. Gallen, Switzerland) was used as an inducer of liver damage and was dissolved in distilled water and injected IP to the experimental rats in concentrations of 300 mg/kg body weight. [ 20 ] Mel (Sigma‐Aldrich, St. Gallen, Switzerland) used as an antioxidant substance in the experiment, was dissolved in ethanol and IP administered to rats at a dosage of 10 mg/kg body weight. [ 19 ]…”

Section: Methodsmentioning

confidence: 99%

Assessment of the protective and therapeutic effect of melatonin against thioacetamide‐induced acute liver damage

Sayan

Karabulut

Özdamar

2020

J Biochem & Molecular Tox

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Acute or chronic damage to the liver may occur through alcohol, drugs, viruses, genetic disorders, and toxicity. In this study, we planned to investigate the protective and therapeutic effects of melatonin (Mel) by causing damage to the liver with thioacetamide (TAA). Thirty‐five rats were used. Group I: control group (seven pieces), group II: Mel group (seven pieces) the single dose on the first day of the experiment was 10 mg/kg, group III: TAA (seven pieces) 300 mg/kg with 24‐hour intervals, two doses, group IV: Mel + TAA group (seven pieces) 10 mg/kg single dose Mel was applied 24 hours before TAA application, group V: TAA + Mel group (seven pieces) single dose (24th hour) of 10 mg/kg Mel was administered after TAA (300 mg/kg) two doses. The liver histology was evaluated. Apoptosis, autophagy, and necrosis markers in tissue were determined by immunohistochemistry. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) levels in blood serum samples and transforming growth factor‐β (TGF‐β) and tumor necrosis factor‐α (TNF‐α) levels were determined in liver tissue. TAA affected histologically the classical lobule structure both in cell cords and sinusoids. Caspase‐3, RIP3, and LC3 levels were increased in group III compared with the control group. TAA did not cause a statistically significant change in TNF‐α level but decreased the TGF‐β level significantly. AST and ALT levels were statistically significant in group II and V compared with group I, the ALP level was significant in group IV compared with group II. The results of this study showed that TAA caused significant damage to tissues and increased cell death, Mel was found to have more therapeutic than the protective effect on tissues.

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Methylprednisolone prevents bacterial translocation in thioacetamide-induced liver failure in rats

Cited by 2 publications

References 16 publications

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Assessment of the protective and therapeutic effect of melatonin against thioacetamide‐induced acute liver damage

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