Methylprednisolone as an antiemetic during cancer chemotherapy—a pilot study

Rich, William M.; Abdulhayoḡlu, Gazi; DiSaia, Philip J.

doi:10.1016/0090-8258(80)90027-x

Cited by 149 publications

(55 citation statements)

References 3 publications

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“…It may act through prostaglandin antagonism, 18 serotonin inhibition in the gut, 19 and by releasing endorphins. 20 Liu and colleagues 21,22 demonstrated that dexamethasone alone at doses of 5 mg and 2.5 mg are as effective as 10 mg, in reducing the incidence of PONV.…”

Section: Objectif : La Combinaison De Médicaments Antiémétiques Pourrmentioning

confidence: 99%

Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy

Elhakim

Nafie

Mahmoud

et al. 2002

Can J Anesth/J Can Anesth

105

100

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Section: Objectif : La Combinaison De Médicaments Antiémétiques Pourrmentioning

confidence: 99%

Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy

Elhakim

Nafie

Mahmoud

et al. 2002

Can J Anesth/J Can Anesth

105

100

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“…We found that dexamethasone 0.5 mg·kg -1 up to 8 mg administered before tonsillectomy markedly decreased vomiting in children both in the PACU (early vomiting) and on the ward up to 24 hr after surgery (late vomiting). Dexamethasone may exert an antiemetic action via prostaglandin antagonism, 11 serotonin inhibition in the gut, 12 and release of endorphins. 13 Aouad et al 14 and Pappas et al 15 have reported a significant decrease in the incidence of vomiting in dexamethasone treated children only during delayed recovery.…”

Section: Figure 1 Median Children's Hospital Eastern Ontario Painmentioning

confidence: 99%

Dexamethasone reduces postoperative vomiting and pain after pediatric tonsillectomy

Elhakim

Rashed

et al. 2003

Can J Anesth/J Can Anesth

148

121

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P Pu ur rp po os se e: : Previous studies on dexamethasone's antiemetic and analgesic potential in children undergoing tonsillectomy have produced conflicting results. The aim of this study was to evaluate the effects of a single dose of dexamethasone on the incidence and severity of postoperative vomiting and pain in children undergoing electrocautery tonsillectomy under standardized general anesthesia. M Me et th ho od ds s: :In a double-blinded study, 120 patients were randomly allocated to receive either dexamethasone 0.5 mg·kg -1 (maximum dose 8 mg) iv or an equivalent volume of saline preoperatively. The incidence of early and late vomiting, need for rescue antiemetics, time to first oral intake, time to first demand of analgesia and analgesic consumption were compared in both groups. Pain scores used included Children's Hospital Eastern Ontario Pain Scale, "faces", and a 0-10 visual analogue pain scale.R Re es su ul lt ts s: : Compared with placebo, dexamethasone significantly decreased the incidence of early and late vomiting (P < 0.05, P < 0.001 respectively). Fewer patients in the dexamethasone group needed antiemetic rescue (P < 0.01). The time to first oral intake was shorter, and the time to first dose of analgesic was longer in the dexamethasone group (P < 0.01). Pain scores 30 min after extubation were lower (P < 0.05) in the dexamethasone group. At 12 and 24 hr postoperative swallowing was still significantly less painful in the dexamethasone group than in the control group (P < 0.01).C Co on nc cl lu us si io on n: : Preoperative dexamethasone 0.5 mg·kg -1 iv reduced both postoperative vomiting and pain in children after electrocautery tonsillectomy. ONSILLECTOMY is one of the most frequently performed ambulatory surgical procedures in children and is associated with an incidence of postoperative vomiting ranging between 40% and 73%. 1-3 The introduction of an electrodissection surgical technique has virtually eliminated immediate postoperative hemorrhage. However, it may cause more pain, discomfort Résultats : Comparée au placebo, la dexaméthasone a significativement réduit l'incidence de vomissements précoces et tardifs (P < 0,05, P < 0,001 respectivement). Peu de patients ayant reçu la dexaméthasone ont eu besoin d'antiémétique de secours (P < 0,01

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“…These features of dexamethasone increase patient satisfaction. Although the mechanism of action of dexamethasone is not known exactly, it was held responsible for central inhibition of prostaglandin synthesis, reduction of stimuli in operation site with the anti-inflammatory effect and reduction of serotonin release from the Moreover, the permeability changes in the central nervous system have been suggested to be responsible for the mechanism [15][16][17].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dexamethasone in Tramadol Induced Nausea and Vomiting

Gülhaş¹,

Şanlı²,

Aslan³

et al. 2016

Med-Science

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We aimed to investigate the efficacy of a single dose bolus of dexamethasone on tramadol induced nausea and vomiting in our study. After 2, 4, 6, 12 and 24 hours. Although the incidence of nausea and vomiting, and pain scores at 2 and 4 hours were not statistically significant, they were lower in Gorup D compared to Group K (p>0.05). 14 patients in Group K required additional antiemetics and 12 patients in Group D required additional antiemetics (p>0.05

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Methylprednisolone as an antiemetic during cancer chemotherapy—a pilot study

Cited by 149 publications

References 3 publications

Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy

Dexamethasone 8 mg in combination with ondansetron 4 mg appears to be the optimal dose for the prevention of nausea and vomiting after laparoscopic cholecystectomy

Dexamethasone reduces postoperative vomiting and pain after pediatric tonsillectomy

The Effect of Dexamethasone in Tramadol Induced Nausea and Vomiting

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