Methylprednisolone aceponate (MPA)* — a new therapeutic for eczema: A pharmacological overview

Zaumseil, R.‐P.; Kecskés, Ambrus; Täuber, U.; Töpert, M.

doi:10.3109/09546639209092765

Cited by 18 publications

(24 citation statements)

References 3 publications

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“…Méthylprednisolone aceponate (MPA, Advantan'") is a new, nonhalogenated corticoid diester for the treatment of eczematous disor ders [ 1 ]. It is an effective new steroid.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydrocortisone, Methylprednisolone Aceponate and Momethasone Furoate on Collagen Synthesis in Human Skin in vivo

Haapasaari

Risteli

Karvonen

et al. 1997

Skin Pharmacol Physiol

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Background: Topical corticoids decrease de novo collagen synthesis in the human skin. Objective: We studied the effect of three corticoids, hydrocortisone (HC), methylprednisolone aceponate (MPA) and momethasone furoate (MMF) on the de novo synthesis of type I and III collagens. Methods: Fifteen healthy male volunteers treated four areas marked on their abdominal skin for 1 week. HC was applied twice a day, MPA and MMF once a day plus vehicle once a day and vehicle twice a day. After the treatment, suction blisters were induced on the treated areas, the suction blister fluid (SBF) was collected and procollagen propeptides of type I and III procollagens (PINP, PIIINP, respectively) were analyzed by radioimmunological assays. The protein concentration in SBF was determined by a colorimetric method. Results: All the corticoids studied decreased the procollagen propeptide concentrations in SBF. HC decreased PINP concentration by 66%, MPA by 68% and MMF by 72%. HC decreased PIIINP by 62%, MPA by 68% and MMF by 72%. The protein concentration in SBF was decreased by 11-15% by these topical corticoids. Conclusion: HC decreases the concentration of procollagen propeptides in human skin in males to nearly the same extent as MPA and MMF.

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“…Méthylprednisolone aceponate (MPA, Advantan'") is a new, nonhalogenated corticoid diester for the treatment of eczematous disor ders [ 1 ]. It is an effective new steroid.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hydrocortisone, Methylprednisolone Aceponate and Momethasone Furoate on Collagen Synthesis in Human Skin in vivo

Haapasaari

Risteli

Karvonen

et al. 1997

Skin Pharmacol Physiol

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“…The therapeutic action of MPA clearly exceeded that of hydrocortisone butyrate since it proved three times more effective. Investigations in humans, using thc UV erythema inhibition test, demonstrated an anti-inflammatory activity comparable to that of mometasone furoate [22].…”

Section: Discussionmentioning

confidence: 95%

B‐Scanning assessment of the anti‐inflammatory activity of methylprednisolone aceponate on experimentally induced allergic reactions

Seidenari¹,

Nardo²,

Giannetti³

1994

Acad Dermatol Venereol

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BackgroundThe inhibitory activity of methylprednisolone aceponate (MPA) on experimentally induced allergic reactions was assessed by an cchographic method employing a B-scanner and a dedicated software, and compared to the effects of corticosteroids of known potency.Material and methods Experimental lesions, which were induced by patch testing 12 sensitized subjects with 5% nickel sulfate (pet.), were treated with two medications of different steroids (clobetasol propionate, fluocinolone acetonide, clobetasone butyrate., and methylprednisolone aceponate), performed 16 and 40 h after the application of the nickel patch tests. Clinical and echographic evaluations were carried out at the beginning of the experiment, and 64 hours after the induction of the reactions. Values of skin thickness and of extension of hypo-reflecting dermal areas were determined by image processing on echographic recordings.Results Rank order of the potency of the tested cortieosteroids, as evaluated by echography, was the same as the one obtained by visual scoring. MPA proved to be less effective than clobetasol propionate, more effective than clobetasone butyrate, and equally as effective as fluocinolone acetonide.Conclusion This experiment indieated MPA can be considered a potent steroid.

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“…Methylation at C-6 increases receptor binding -and therefore potency -while double esterification significantly increases lipophilicity, facilitating rapid and efficient penetration of the stratum corneum and increased bioavailability. 35,36 Unlike other potent Luger corticosteroids, MPA does not contain a halogen at C-9; this contributes to a high degree of dissociation between topical and systemic activity. 36 MPA is metabolized rapidly by esterases within the epidermis and dermis.…”

Section: Use Of Mpa In Admentioning

confidence: 98%

Balancing efficacy and safety in the management of atopic dermatitis: the role of methylprednisolone aceponate

Luger

2011

Acad Dermatol Venereol

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Although emollients can be sufficient to manage mild atopic dermatitis (AD), acute flares resulting in moderate-to-severe symptoms require treatment with anti-inflammatory agents, such as topical corticosteroids (TCs) and topical calcineurin inhibitors (TCIs). This review examines the role of a member of the newest class of TCs, the fourth-generation compound methylprednisolone aceponate (MPA) in AD management, with reference to the chemical structure, pharmacokinetics, efficacy in AD, safety assessed in preclinical and clinical trials and dosing considerations. MPA has an optimized efficacy/safety profile with minimal local or systemic adverse effects. In addition, it offers the opportunity for once-daily dosing, which provides benefits in terms of patient compliance with treatment.

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Methylprednisolone aceponate (MPA)* — a new therapeutic for eczema: A pharmacological overview

Cited by 18 publications

References 3 publications

Effect of Hydrocortisone, Methylprednisolone Aceponate and Momethasone Furoate on Collagen Synthesis in Human Skin in vivo

Effect of Hydrocortisone, Methylprednisolone Aceponate and Momethasone Furoate on Collagen Synthesis in Human Skin in vivo

B‐Scanning assessment of the anti‐inflammatory activity of methylprednisolone aceponate on experimentally induced allergic reactions

Balancing efficacy and safety in the management of atopic dermatitis: the role of methylprednisolone aceponate

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