Methylphenidate oral dose plasma concentrations and behavioral response in children

Winsberg, Bertrand G.; Kupietz, Samuel S.; Sverd, Jeffrey; Hungund, Basalingappa L.; Young, Nancy L.

doi:10.1007/bf00449120

Cited by 48 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, this cannot explain the failure of some studies to show effects of MPH on the working memory of children. Winsberg, Kupietz, Sverd, Hungund, and Young (1982) found no effect of 0.25, 0.5, or 1.0 mg/kg MPH on the accuracy of children with ADHD in a picture recognition task. Likewise, Douglas, Barr, Amin, O'Neill, and Britton (1988) found no effect of 0.15, 0.3, or 0.6 mg/kg MPH on children's learning of paired associates.…”

Section: Discussionmentioning

confidence: 74%

Effects of methylphenidate on working memory in pigeons

Wright

White

2003

Cognitive, Affective, & Behavioral Neuroscience

View full text Add to dashboard Cite

To assess the effects of methylphenidate on working memory, pigeons were trained in a delayed matching-to-sample task. Delay interval duration (0.2, 1, 3, 6, or 12 sec) was varied within sessions in order to separate delay-dependent from delay-independent effects of the drug on performance. A reduction in the sample response requirement from five responses to one response effectively reduced attention to the stimulus and impaired overall accuracy. Methylphenidate was administered in doses of 0.0 (saline control), 0.25, 2.5, and 10 mg/kg. Relative to performance with saline, accuracy was significantly reduced with 10 mg/kg methylphenidate to the same extent in both fixed ratio (FR) 1 and FR 5 conditions. The smaller doses had no effect, and there was no evidence that accuracy improved with drug administration. Intercepts and slopes of exponential functions fitted to measures of discriminability plotted as a function of delay showed that methylphenidate affected delay-independent aspects of performance (initial discriminability), but not delay-dependent aspects (rate of forgetting).

show abstract

Section: Discussionmentioning

confidence: 74%

Effects of methylphenidate on working memory in pigeons

Wright

White

2003

Cognitive, Affective, & Behavioral Neuroscience

View full text Add to dashboard Cite

show abstract

“…In addition, of all the participants taking part in the parent investigation (n ¼ 70) only three were kept by their family on DHA after the parent investigation ended, and none of those three participants or any other taking other types of supplements was included in this study (n ¼ 54). Altogether, these findings and approaches permitted the unaltered assessment of the test-retest reliability of the CCTT, not simply because DHA failed to impact ADHD and participants who were subjectively believed to have benefited from DHA or other essential fatty acids were excluded from this study, but because children were additionally off their stimulant medication for a reasonable wash-out period prior to their participation in this study (Winsberg, Kupietz, Sverd, Hungund, & Young, 1982).…”

Section: Resultsmentioning

confidence: 99%

Children's Color Trails Test 1 & 2: Test–Retest Reliability and Factorial Validity

Llorente

Voigt

Williams

et al. 2009

The Clinical Neuropsychologist

View full text Add to dashboard Cite

This investigation examined the test-retest reliability and the factorial validity of the Children's Color Trails Test 1 & 2 (CCTT) using two distinct and independent studies and their respective research samples. The reliability of the CCTT was evaluated in a study with 6-12-year-old children (n = 54) strictly selected and diagnosed with attention-deficit/hyperactivity disorder from an interventional protocol using test-retest coefficients at 8- and 16-week time intervals. Factorial validity was investigated using groups of children with traumatic brain injury (TBI) (n = 137), children with other types of trauma than brain or head injury (Other Injury) (n = 132), and healthy controls (n = 114) from a protocol assessing the neuropsychological sequelae of traumatic brain injury. The results revealed completion time test-retest reliability in the moderate range, which may be considered modest (r(tt) =.46-.68) in this sample of children with ADHD. Interference reliability coefficients were greater and in the moderate-high range (r(tt) =.75-.78). Factorial analytic results revealed a three-factor structure solution for all three groups (TBI, Other Injury, and controls). As a result of CCTT's factorial loadings, Factor 1 was labeled speed of perceptual tracking and susceptibility to interference, Factor 2 was labeled inattention and impulsivity, and Factor 3 was labeled simple inattention. Relative limitations and strengths associated with this investigation including practice effects associated with repeated CCTT administrations also were addressed within the context of the extant findings and existing trail-making test literature.

show abstract

“…The TOVA was administered to each participant after being off stimulant medication for at least 24 hours prior to participation so that scores on these procedures did not reflect the effect of the stimulant medication (Winsberg, Kupietz, Sverd, Hungund, & Young, 1982). The TOVA was performed in the morning for 90% of the participants.…”

Section: Methodsmentioning

confidence: 99%

The Test of Variables of Attention (TOVA): Internal Consistency (Q₁vs. Q₂and Q₃vs. Q₄) in Children with Attention Deficit/Hyperactivity Disorder (ADHD)

Llorente

Voigt

Jensen

et al. 2008

Child Neuropsychology

View full text Add to dashboard Cite

The internal consistency of the Test of Variables of Attention (TOVA) was examined in a cohort of 6- to 12-year-old children (N = 63) strictly diagnosed with ADHD. The internal consistency of errors of omission (OMM), errors of commission (COM), response time (RT), and response time variability (RTV) of different test conditions (stimulus infrequent condition [Q₁ vs. Q₂] and stimulus frequent condition [Q₃ vs. Q₄]) was assessed via correlation analyses. All TOVA index scores under investigation assessing its internal consistency exhibited statistically significant correlations. All correlations fell in the moderate-high range.

show abstract

Methylphenidate oral dose plasma concentrations and behavioral response in children

Cited by 48 publications

References 11 publications

Effects of methylphenidate on working memory in pigeons

Effects of methylphenidate on working memory in pigeons

Children's Color Trails Test 1 & 2: Test–Retest Reliability and Factorial Validity

The Test of Variables of Attention (TOVA): Internal Consistency (Q₁vs. Q₂and Q₃vs. Q₄) in Children with Attention Deficit/Hyperactivity Disorder (ADHD)

Contact Info

Product

Resources

About

Methylphenidate oral dose plasma concentrations and behavioral response in children

Cited by 48 publications

References 11 publications

Effects of methylphenidate on working memory in pigeons

Effects of methylphenidate on working memory in pigeons

Children's Color Trails Test 1 & 2: Test–Retest Reliability and Factorial Validity

The Test of Variables of Attention (TOVA): Internal Consistency (Q1vs. Q2and Q3vs. Q4) in Children with Attention Deficit/Hyperactivity Disorder (ADHD)

Contact Info

Product

Resources

About

The Test of Variables of Attention (TOVA): Internal Consistency (Q₁vs. Q₂and Q₃vs. Q₄) in Children with Attention Deficit/Hyperactivity Disorder (ADHD)