Methylphenidate in Aggressive-Hyperactive Boys: I. Effects on Peer Aggression in Public School Settings

A Double-Blind Placebo-Controlled Study of Lithium in Hospitalized Aggressive Children and Adolescents With Conduct Disorder

“…Of the psychoactive agents, antipsychotics may reduce aggression, but use is limited by sedation and extrapyramidal side effects, including tardive dyskinesia, 19,[22][23][24] and controlled studies of stimulants are not in agreement regarding efficacy. [25][26][27][28][29][30][31] Lithium carbonate has shown promise for reducing aggressive behavior in animals and humans. 32 Findings are mixed regarding its efficacy in children and adolescents.…”

Recent advances in paediatric psychopharmacology: A brief overview

“…A number of double blind placebo controlled studies (Klorman et al, , 1988Barkley, 1988;Hinshaw et al, 1989;Gadow et al, 1990;Kaplan et al, 1990) in children with hyperactivity and conduct disorder have demonstrated moderate improvement in conduct symptoms such as aggressive behaviour. Nonetheless, there was high individual variability and it is difficult to draw any f i r m conclusions.…”

“…Controlled trials suggest that methylphenidate and dextroamphetamine may be effective in reducing mild but not severe forms of aggressive behaviour (Abikoff and Gittleman, 1985;Gadow et al, 1990).…”

A linear growth curve analysis of inpatient treatment response by conduct‐disordered, ADHD, and comorbid preadolescents

“…This was of interest due to conflicting reports regarding the efficacy of psychostimulants in treating aggressive behaviors among comorbid children. While it is clear that methylphenidate attenuates symptoms of hyperactivity in such cases [e.g., Gadow et al, 1990;Klein et al, 1997], evidence for attenuation of aggressive symptoms is mixed. Although several authors have reported significant symptom improvement [e.g., Gadow et al, 1990;Kaplan et al, 1990;Klein et al, 1997;Murphy et al, 1992], close scrutiny of these reports reveals that effects were inconsistent across contexts and measures.…”

“…While it is clear that methylphenidate attenuates symptoms of hyperactivity in such cases [e.g., Gadow et al, 1990;Klein et al, 1997], evidence for attenuation of aggressive symptoms is mixed. Although several authors have reported significant symptom improvement [e.g., Gadow et al, 1990;Kaplan et al, 1990;Klein et al, 1997;Murphy et al, 1992], close scrutiny of these reports reveals that effects were inconsistent across contexts and measures. Thus, while Gadow et al employed Kolko et al, [1999], who reported no significant medication effects on overt aggression in patients enrolled in a partial hospitalization program.…”