Methylphenidate improves deficient error evaluation in children with ADHD: An event-related brain potential study

Jonkman, Lisa M.; Melis, Jessica. J.M. van; Kemner, Chantal; Markus, C. Rob

doi:10.1016/j.biopsycho.2007.08.004

Cited by 100 publications

(118 citation statements)

References 67 publications

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“…In children with DSM-III-R defined ADHD who completed a Flanker task, both ERN and Pe were reported to be larger on error than correct response trials as expected, with reduced Pe indicating reduced error awareness in the clinical group (Jonkman et al, 2007;see Table 2). In a mixed-subtype AD/HD group with a large proportion of participants with comorbid ODD, reduced ERN after errors in a Flanker task was interpreted as a performance monitoring deficit (van Meel et al, 2007).…”

Section: Performance Monitoringsupporting

confidence: 61%

“…Participants respond with a button-press to the direction of a target arrow and ignore distracter stimuli flanking the target, which may be congruent, incongruent, or neutral with regard to the target. Jonkman et al (2007) reported that children with DSM-III-R defined ADHD and controls showed larger N2 to correct compared to incorrect incongruent trials, with a trend towards larger N2 overall for ADHD indicating enhanced sensitivity to conflict caused by the flanker stimuli.…”

Section: Flanker Taskmentioning

confidence: 99%

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Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Johnstone

Barry

Clarke

2013

Clinical Neurophysiology

145

132

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This article reviews the event-related potential (ERP) literature in relation to attention-deficit/hyperactivity disorder (AD/HD) over the years [2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012]. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are reviewed, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components. These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters. • Research focus and intensity has been in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions.• Some consistent differences from healthy controls are emerging, but more emphasis on replication and extension studies is needed to increase the consistency and specificity of results. AbstractThis article reviews the event-related potential (ERP) literature in relation to attentiondeficit/hyperactivity disorder (AD/HD) over the years 2002 to 2012. ERP studies exploring various aspects of brain functioning in children and adolescents with AD/HD are examined, with a focus on group effects and interpretations in the domains of attention, inhibitory control, performance monitoring, non-pharmacological treatments, and ERP/energetics interactions. There has been a distinct shift in research intensity over the past 10 years, with a large increase in ERP studies conducted in the areas of inhibitory control and performance monitoring. Overall, the research has identified a substantial number of ERP correlates of AD/HD. Robust differences from healthy controls have been reported in early orienting, inhibitory control, and error-processing components.These data offer potential to improve our understanding of the specific brain dysfunction(s) which contribute to the disorder. The literature would benefit from a more rigorous approach to clinical group composition and consideration of age effects, as well as increased emphasis on replication and extension studies using exacting participant, task, and analysis parameters.

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Section: Performance Monitoringsupporting

confidence: 61%

Section: Flanker Taskmentioning

confidence: 99%

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Johnstone

Barry

Clarke

2013

Clinical Neurophysiology

145

132

View full text Add to dashboard Cite

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“…In the flanker task, children with AD/HD show slower RTs and lower response accuracy than typically-developing children for all stimulus types (Johnstone et al, 2010;Jonkman et al, 2007;Konrad et al, 2006). Compared to typically-developing children, children with AD/HD also show a more delayed RT to incongruent stimuli compared to neutral stimuli (Jonkman et al, 2007;Ridderinkhof et al, 2005).…”

Section: Introductionmentioning

confidence: 89%

“…Compared to typically-developing children, children with AD/HD also show a more delayed RT to incongruent stimuli compared to neutral stimuli (Jonkman et al, 2007;Ridderinkhof et al, 2005).…”

Section: Introductionmentioning

confidence: 92%

Event-rate effects in the flanker task: ERPs and task performance in children with and without AD/HD

Johnstone

Galletta

2013

International Journal of Psychophysiology

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Demanding tasks require a greater amount of effort, in which case individuals are required to alter their energetic-state to a level appropriate to perform the task. According to the Cognitive-Energetic Model (CEM), children with AD/HD are unable to effectively modulate their energetic state, leading to task underperformance. Using an Eriksen flanker task with varying event-rates, the current study compared the ability of typically-developing children and children with AD/HD to modulate their energetic state. In line with the CEM, it was predicted that children with AD/HD would underperform in the fast and slow eventrates. Results indicated that the groups did not differ in commission errors (i.e., incorrect responses). However, children with AD/HD made more omission errors to incongruent stimuli at the fast and slow eventrates, compared to controls. N2 amplitude was significantly larger for the AD/HD than control group in the slow event-rate. It is concluded that the energetic state modulation dysfunction in children with AD/HD results in an inability to attend to the task, as opposed to an inability to perform the task itself. Furthermore, these task performance differences did not manifest in either the N2 or P3 ERP components. Therefore, inattention in children with AD/HD may have its locus in response preparation, as opposed to stimulus processing, but more research is required to validate these conjectures. Abstract: Demanding tasks require a greater amount of effort, in which case individuals are required to alter their energetic-state to a level appropriate to perform the task. According to the CognitiveEnergetic Model (CEM), children with AD/HD are unable to effectively modulate their energetic state, leading to task underperformance. Using an Eriksen flanker task with varying event-rates, the current study compared the ability of typically-developing children and children with AD/HD to modulate their energetic state. In line with the CEM, it was predicted that children with AD/HD would underperform in the fast and slow event-rates. Results indicated that the groups did not differ in commission errors (i.e., incorrect responses). However, children with AD/HD made more omission errors (i.e., impulsively early or non-responses) to incongruent stimuli at the fast and slow event-rates, compared to controls. N2 amplitude was significantly larger for the AD/HD than control group in the slow event-rate. It is concluded that the energetic state modulation dysfunction in children with AD/HD results in an inability to attend to the task, as opposed to an inability to perform the task itself. Furthermore, these task performance differences did not manifest in either the N2 or P3 ERP components. Therefore, inattention in children with AD/HD may have its locus in response preparation, as opposed to stimulus processing, but more research is required to validate these conjectures. Highlights Children with AD/HD unable to effectively modulate energetic state  Event-rate varied during interference control in c...

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“…Given that ERN and Pe are typically ascribed to ACC (Falkenstein, Hohnsbein, Hoormann, & Blanke, 1991;Gehring, Goss, Coles, Meyer, & Donchin, 1993;Herrmann, Rommler, Ehlis, Heidrich, & Fallgatter, 2004;Posner & Dehaene, 1994), this suggests an impairment of ACC in ADHD patients. In addition, dopamine agonists restore the Pe amplitude (Groen, et al, 2008;Jonkman, van Melis, Kemner, & Markus, 2007). Moreover, neuroimaging studies document metabolic hypoactivation (Bush, et al, 1999;Rubia, et al, 1999) and hypotrophy of ACC (Makris, et al, 2007;Makris, et al, 2010;Seidman, et al, 2006).…”

Section: Acc Dysfunction In Adhdmentioning

confidence: 98%

Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD

et al. 2013

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Attention Deficit/Hyperactivity Disorder (ADHD) is a pathophysiologically complex and heterogeneous condition with both cognitive and motivational components. We propose a novel computational hypothesis of motivational deficits in ADHD, drawing together recent evidence on the role of anterior cingulate cortex (ACC) and associated meso-limbic dopamine circuits in both reinforcement learning and ADHD. Based on findings of dopamine dysregulation and ACC involvement in ADHD we simulated a lesion in a previously validated computational model of ACC (Reward Value and Prediction Model, RVPM). We explored the effects of the lesion on the processing of reinforcement signals. We tested specific behavioural predictions about the profile of reinforcement-related deficits in ADHD in three experimental contexts; probability tracking task, partial and continuous reward schedules, and immediate versus delayed rewards. In addition, predictions were made at the neurophysiological level.Behavioural and neurophysiological predictions from the RVPM-based lesion-model of motivational dysfunction in ADHD were confirmed by data from previously published studies. RVPM represents a promising model of ADHD reinforcement learning suggesting that ACC dysregulation might play a role in the pathogenesis of motivational deficits in ADHD. However, more behavioral and neurophysiological studies are required to test core predictions of the model. In addition, the interaction with different brain networks underpinning other aspects of ADHD neuropathology (i.e., executive function) needs to be better understood.

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Methylphenidate improves deficient error evaluation in children with ADHD: An event-related brain potential study

Cited by 100 publications

References 67 publications

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Ten years on: A follow-up review of ERP research in attention-deficit/hyperactivity disorder

Event-rate effects in the flanker task: ERPs and task performance in children with and without AD/HD

Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD

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