Methylomic Changes in Response to Micronutrient Supplementation and
            <i>MTHFR</i>
            Genotype

Stevens, Aaron J.; Rucklidge, Julia J.; Darling, Kathryn A; Eggleston, Matthew; Pearson, John; Kennedy, Martin A.

doi:10.2217/epi-2018-0029

Cited by 11 publications

(6 citation statements)

References 88 publications

(70 reference statements)

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“…Targets that would build upon previous micronutrient studies include changes in gut microbiota 45 and methylation. 46 The role of inflammatory cytokines also merits exploration, given their association with infant negative affect when maternal cytokines levels are high in the last trimester of pregnancy. 47 Considering dietary quality and intake is important, as poor diet quality is linked with mental health issues.…”

Section: Discussionmentioning

confidence: 99%

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Johnstone

Hatsu

Tost

et al. 2022

Journal of the American Academy of Child & Adolescent Psych

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Section: Discussionmentioning

confidence: 99%

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Johnstone

Hatsu

Tost

et al. 2022

Journal of the American Academy of Child & Adolescent Psych

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“…Without an adequate supply, methylation will be impaired, which in turn may affect genetic expression and result in poor physical and mental health. Increasing the supply of nutrients has been shown to modestly increase methylation of the genome, illustrating the role that nutrients might play in gene modification (Stevens et al, 2018).…”

Section: Modifying Genetic Expressionmentioning

confidence: 99%

“…The biggest category of gene-modifying variables appears to come from the environment, especially the nutritional environment. There is preliminary evidence that nutrients may be epigenetic modifiers in mental health (Stevens et al, 2018), but one of the best illustrations of the role that nutrition can play in genetic expression comes from honeybees.…”

Section: Modifying Genetic Expressionmentioning

confidence: 99%

Nutrition Provides the Essential Foundation for Optimizing Mental Health

Rucklidge

Johnstone

Kaplan

2021

Evidence-Based Practice in Child and Adolescent Mental Health

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Although current evidence confirms the importance of diet for mental health, many psychologists avoid discussing dietary intake with clients, questioning whether this information is within their scope of practice. This article provides psychologists with a review focused on the connection between what we eat and how we feel. Eating a healthy, whole-foods-based diet is an important tool to promote mental health recovery and maintenance. We begin by reviewing several mechanisms by which nutrients maximize brain health, including enabling metabolic reactions to occur, supporting mitochondrial function, reducing inflammation and assisting with detoxification. Understanding the vital role of nutrients for brain health will aid clients in understanding the importance of optimizing their intake of a range of nutrients in order to maximize their mental health: no single nutrient is sufficient. Next, we summarize evidence relating diet to mental health, followed by a consideration of circumstances that may contribute to a client requiring additional nutrients, such as chronic stress, medication use, individual biochemistry, and consuming nutrientdepleted food. The evidence base for treating psychological problems in children with supplementary nutrients is then reviewed, and a case study of a child whose self-regulatory skills improved with broad-spectrum multinutrients is used to illustrate this treatment. The breadth and consistency of the research highlights the importance of children receiving a good foundation of nutrients for optimizing brain health. Finally, we offer practical suggestions for psychologists to incorporate this information into their clinical practice and discuss these suggestions within the context of informed consent.

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“…It would also be useful to identify the mechanism by which the nutrients exert their effects, within the framework of triage theory or otherwise. Other research has identified that the nutrients increase diversity of the microbiome (Stevens et al, 2019) as well as show small epigenetic effects in terms of increased methylation (Stevens et al, 2018); however, biomarkers could usefully be collected before and after exposure to the nutrients/ placebo under stressful situations to better understand the impact that the nutrients may have on cortisol response.…”

Section: Discussionmentioning

confidence: 99%

Massacre, Earthquake, Flood

Rucklidge

Afzali

Kaplan

et al. 2021

International Perspectives in Psychology

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Abstract. Natural (e.g., earthquake, flood, wildfires) and human-made (e.g., terrorism, civil strife) disasters are inevitable, can cause extensive disruption, and produce chronic and disabling psychological injuries leading to formal diagnoses (e.g., post-traumatic stress disorder [PTSD]). Following natural disasters of earthquake (Christchurch, Aotearoa/New Zealand, 2010–11) and flood (Calgary, Canada, 2013), controlled research showed statistically and clinically significant reductions in psychological distress for survivors who consumed minerals and vitamins (micronutrients) in the following months. Following a mass shooting in Christchurch (March 15, 2019), where a gunman entered mosques during Friday prayers and killed and injured many people, micronutrients were offered to survivors as a clinical service based on translational science principles and adapted to be culturally appropriate. In this first translational science study in the area of nutrition and disasters, clinical results were reported for 24 clients who completed the Impact of Event Scale – Revised (IES-R), the Depression Anxiety Stress Scales (DASS), and the Modified-Clinical Global Impression (M-CGI-I). The findings clearly replicated prior controlled research. The IES-R Cohen’s d ESs were 1.1 (earthquake), 1.2 (flood), and 1.13 (massacre). Effect sizes (ESs) for the DASS subscales were also consistently positive across all three events. The M-CGI-I identified 58% of the survivors as “responders” (i.e., self-reported as “much” to “very much” improved), in line with those reported in the earthquake (42%) and flood (57%) randomized controlled trials, and PTSD risk reduced from 75% to 17%. Given ease of use and large ESs, this evidence supports the routine use of micronutrients by disaster survivors as part of governmental response.

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Methylomic Changes in Response to Micronutrient Supplementation and MTHFR Genotype

Abstract: Micronutrient supplementation is unlikely to have a substantial biological effect on DNA methylation over 10 weeks; however, the trend toward hypermethylation that we observed is likely to become more marked with longer exposure periods.

Cited by 11 publications

References 88 publications

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Micronutrients for Attention-Deficit/Hyperactivity Disorder in Youths: A Placebo-Controlled Randomized Clinical Trial

Nutrition Provides the Essential Foundation for Optimizing Mental Health

Massacre, Earthquake, Flood

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