Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner

Dreiem, Anne; Shan, Mangting; Okoniewski, Richard; Sanchez-Morrissey, Susana; Seegal, Richard F.

doi:10.1016/j.ntt.2009.05.001

Cited by 48 publications

(33 citation statements)

References 35 publications

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“…Most notably, Lin et al, (2011) recently reported a significant reduction in DAT function in the striatum of workers occupationally exposed to mercury vapor. This dysfunction in DAT was similarly demonstrated in vitro with a reduction in dopamine uptake in synaptosomes treated with mercury (Hare et al, 1990, Dreiem et al, 2009). In addition, mercury exposure reduced neurites of dopaminergic neurons isolated from the ventral mesencephalon and caused a reduction of striatal dopamine in mice exposed to methylmercury (Gotz et al, 2002, Bourdineaud et al, 2011).…”

Section: Mercurymentioning

confidence: 62%

Industrial toxicants and Parkinson's disease

et al. 2012

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The exposure of the human population to environmental contaminants is recognized as a significant contributing factor for the development of Parkinson’s disease (PD) and other forms of parkinsonism. While pesticides have repeatedly been identified as risk factors for PD, these compounds represent only a subset of environmental toxicants that we are exposed to on a regular basis. Thus, non-pesticide contaminants, such as metals, solvents, and other organohalogen compounds have also been implicated in the clinical and pathological manifestations of these movement disorders and it is these non-pesticide compounds that are the subject of this review. As toxic exposures to these classes of compounds can result in a spectrum of PD or PD-related disorders, it is imperative to appreciate shared clinico-pathological characteristics or mechanisms of action of these compounds in order to further delineate the resultant disorders as well as identify improved preventive strategies or therapeutic interventions.

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Section: Mercurymentioning

confidence: 62%

Industrial toxicants and Parkinson's disease

et al. 2012

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“…10 Central nervous system effects of mercury have been shown in animal models 11 , including changes in rodent dopaminergic function 12 , providing a biologic basis for effects on ADHD. 13 Epidemiologic studies of lower-dose mercury exposure are inconsistent 14 , with some studies showing associations between mercury and ADHD-related behaviors 15, 16 and others reporting null associations.…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder–Related Behavior in Children

Sagiv¹,

Thurston²,

Bellinger³

et al. 2012

Arch Pediatr Adolesc Med

159

105

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“…While DAergic neurons are not the only subpopulation susceptible to MeHg, MeHg inhibits DA uptake, and systemic or intrastriatal MeHg administration increases rat striatal DA release [12, 13]. In vitro rat synaptosomes show age-dependent sensitivity to MeHg, characterized by higher DA release and lower DAT activity [4, 14].…”

Section: Introductionmentioning

confidence: 99%

Early-Life Exposure to Methylmercury in Wildtype and pdr-1/parkin Knockout C. elegans

et al. 2013

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We examined the impact of early-life exposure to methylmercury (MeHg) on Caenorhabditis elegans (C. elegans) pdr-1 mutants, addressing gene-environment interactions. We tested the hypothesis that early-life exposure to MeHg and knockout (KO) of pdr-1 (mammalian: parkin/PARK2) exacerbates MeHg toxicity and damage to the dopaminergic (DAergic) system. pdr-1KO worms showed increased lethality and decreased lifespan following MeHg exposure. Mercury (Hg) content, measured with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) was increased in pdr-1KO worms compared to wildtype (N2) controls. 2′7′ dichlorodihydrofluorescein diacetate (H2DCF-DA) assay revealed a significant increase in reactive oxygen species (ROS) in both strains following MeHg exposure; however, while N2 worms showed an increase in skn-1 transcript levels following MeHg exposure, there was no difference in skn-1 induction in pdr-1KO worms. Dopamine-dependent behavioral analysis revealed an effect of MeHg on N2 wildtype worms, but no effect on pdr-1KO worms. Taken together, these results suggest that pdr-1KO worms are more sensitive to MeHg than wildtype worms, but MeHg does not exacerbate behavioral changes related to the absence of pdr-1.

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Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner

Cited by 48 publications

References 35 publications

Industrial toxicants and Parkinson's disease

Industrial toxicants and Parkinson's disease

Prenatal Exposure to Mercury and Fish Consumption During Pregnancy and Attention-Deficit/Hyperactivity Disorder–Related Behavior in Children

Early-Life Exposure to Methylmercury in Wildtype and pdr-1/parkin Knockout C. elegans

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