2012
DOI: 10.1007/s00417-011-1912-5
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Methylglyoxal induces hyperpermeability of the blood–retinal barrier via the loss of tight junction proteins and the activation of matrix metalloproteinases

Abstract: The results suggest that the activation of MMPs by elevated levels of MGO in the retina may facilitate an increase in vascular permeability by a mechanism involving proteolytic degradation of occludin. These findings may have implications for the role of MGO in the pathogenesis of diabetic retinopathy.

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Cited by 35 publications
(19 citation statements)
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References 40 publications
(45 reference statements)
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“…In our previous study, MGO disrupts the tight junction protein, leading to breakage of the BRB [24]. EP was tested for its ability to inhibit BRB breakage in retinas.…”
Section: Resultsmentioning
confidence: 99%
“…In our previous study, MGO disrupts the tight junction protein, leading to breakage of the BRB [24]. EP was tested for its ability to inhibit BRB breakage in retinas.…”
Section: Resultsmentioning
confidence: 99%
“…Endothelial cells of retinal vessels normally have tight junctions that maintain the inner blood-retinal barrier (BRB). 30 During RNV, new retinal vessels are deficient in endothelial tight junctions, leading to retinal vascular hyperpermeability and inflammation that disrupt normal retinal tissue or function. 31 In the BRB, the main physical barrier is formed by retinal endothelial cells, which have a key role in the expression of S100A4 during RNV.…”
Section: Discussionmentioning
confidence: 99%
“…This ultimately leads to fibrosis and retinal detachment. Endothelial cells of the normal retinal vessels have tight junctions that maintain normal inner blood–retinal barrier (BRB)function [12]. During RNV, the new retinal vessels become deficient in such endothelial tight junctions leading to retinal vascular hyperpermeability and inflammation that disrupt normal retinal tissue/function [13].…”
Section: Retinal Neovascularizationmentioning
confidence: 99%
“…In the BRB, the main physical barrier is formed by retinal endothelial cells, but pericytes and retinal glia were found to contribute to the maintenance of the BRB as well [1416]. Therefore, In addition to the loss of endothelial cell tight junction, loss of retinal pericytes during DR abrogates structural vascular integrity and contributes to retinal vascular leakage [12,17]. …”
Section: Retinal Neovascularizationmentioning
confidence: 99%