Methylenetetrahydrofolate Reductase Gene Polymorphisms (C677T and A1298C) and Hemorrhagic Stroke in Moroccan Patients

Abidi, Omar; Haissam, M.; Nahili, Halima; Azhari, A. El; Hilmani, S.; Barakat, Abdelhamid

doi:10.1016/j.jstrokecerebrovasdis.2018.02.029

Cited by 6 publications

(9 citation statements)

References 51 publications

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“…Later a meta-analysis study performed in 2018 reported the association among MTHFR A1298C polymorphism and IS risk [ 15 ]. In recent years, many studies [ 16 – 20 ] have reported the association among MTHFR A1298C polymorphism and stroke risk. But the results were still inconsistent.…”

Section: Introductionmentioning

confidence: 99%

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong

Wang

et al. 2021

Genes and Environ

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Background Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility. Methods A systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model. Conclusions Our meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

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Section: Introductionmentioning

confidence: 99%

MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Dong

Wang

et al. 2021

Genes and Environ

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“…The basic features of the 25 case-control studies ( Nakata et al, 1998 ; Zheng et al, 2000 ; Yingdong et al, 2002 ; Li et al, 2003 ; Zhang et al, 2004 ; Yan et al, 2004 ; Fang and Wu, 2004 ; Ye et al, 2004 ; Żur-Wyrozumska et al, 2017 ; Fang et al, 2005 ; Dikmen et al, 2006 ; Sazci et al, 2006 ; Hu et al, 2007 ; Shen et al, 2007 ; Zhang et al, 2008 ; Ruigrok et al, 2010 ; Hultdin et al, 2011 ; Somarajan et al, 2011 ; Atadzhanov et al, 2013 ; Rui-Rui et al, 2013 ; Das et al, 2015 ; Shao et al, 2016 ; Hu et al, 2016 ; Abidi et al, 2018 ; Jiang et al, 2018 ) included are shown in Table 1 . The incorporated studies ranged from 1998 to 2018, involving mainly Asian populations and some European and African communities.…”

Section: Resultsmentioning

confidence: 99%

“…The incorporated studies ranged from 1998 to 2018, involving mainly Asian populations and some European and African communities. Three different races were involved in these 25 selected studies: two ( Atadzhanov et al, 2013 ; Abidi et al, 2018 ) African, three ( Dikmen et al, 2006 ; Sazci et al, 2006 ; Hultdin et al, 2011 ) Caucasian and the remaining 17 ( Nakata et al, 1998 ; Zheng et al, 2000 ; Yingdong et al, 2002 ; Zhang et al, 2004 ; Yan et al, 2004 ; Fang and Wu, 2004 ; Ye et al, 2004 ; Żur-Wyrozumska et al, 2017 ; Hu et al, 2007 ; Zhang et al, 2008 ; Rui-Rui et al, 2013 ; Shao et al, 2016 ; Hu et al, 2016 ; Jiang et al, 2018 ) Asian. The control population in three of the 25 studies ( Li et al, 2003 ; Shen et al, 2007 ; Das et al, 2015 ) did not meet Hardy-Weinberg equilibrium and be excluded.…”

Section: Resultsmentioning

confidence: 99%

“…All the 20 included studies had moderately high-quality scores. In four of the 20 studies ( Dikmen et al, 2006 ; Sazci et al, 2006 ; Hultdin et al, 2011 ; Abidi et al, 2018 ), A1298C and C677T gene polymorphism and ICH were simultaneously studied, and a total of 3,280 patients with ICH and 9,324 controls were included in this meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, with the continuous emergence of emerging studies, there are some disputes between MTHFR C677T gene polymorphism and ICH. Recent studies in Morocco ( Abidi et al, 2018 ), India ( Somarajan et al, 2011 ; Sagar et al, 2018 ) and other countries reported contradictive results that the genetic MTHFR C677T polymorphism is not related to ICH. Interestingly, a Zambian study showed no C677TTT genotype in their population ( Atadzhanov et al, 2013 ).…”

Section: Introductionmentioning

confidence: 97%

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A systematic review and meta-analysis expounding the relationship between methylene tetrahydrofolate reductase gene polymorphism and the risk of intracerebral hemorrhage among populations

et al. 2022

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Background: The relationship between methylenetetrahydrofolate reductase (MTHFR) gene C677T and A1298C polymorphism with the risk of intracerebral hemorrhage (ICH) has remained to be controversial in recent years. This meta-analysis is aimed to confirm the association of these.Methods: Systematically searching the related studies from the PubMed, Embase, Cochrane Library, China national knowledge internet database from 1 January 1990 to 1 June 2022. The odd ratio (ORs) and 95% confidence interval (CIs) of gene-disease correlation in various gene models were calculated by fixed or random effect model of meta-analysis. We included 20 case-control studies in this meta-analysis with a total of 1,989 ICH patients and 4,032 health controls originated from Asian, Caucasian, and African populations.Results: The statistical analysis demonstrated the association of MTHFR C677T gene polymorphism with ICH in allele model [ORT VS. C = 1.20 (95%CI: 1.06–1.36)]; homozygote model [OR TT VS. CC = 1.50 (95%CI: 1.20–1.88)]; dominant model [OR CT+ TT VS. CC = 1.23 (95%CI: 1.03–1.48)] and recessive model [ORTT VS. CT+CC = 1.37 (95%CI: 1.17–1.60)]. Besides, we also found the relationship of MTHFR C677T gene polymorphism with Asian in four comparison model (ORT VS. C = 1.19.95%CI:1.09–1.37, ORTT VS. CC = 1.46.95%CI: 1.15–1.85, OR CT+ TT VS. CC = 1.25.95%CI: 1.01–1.54, ORTT VS. CT+CC = 1.34.95%CI: 1.54–1.17) and Caucasian in four comparison model (ORT VS. C = 1.90.95%CI: 1.22–2.97, ORTT VS. CC = 2.67.95%CI: 1.42–5.00, OR CT+ TT VS. CC = 1.56.95%CI: 1.05–2.32, ORTT VS. CT+CC = 2.25.95%CI: 1.46–4.00). But no statistically significant correlation between A1298C polymorphism and the occurrence of ICH was detected in four studies.Conclusion: MTHFR C677T gene polymorphism increases the risk of ICH in Asian and Caucasian populations but has no impact on the incidence in African communities. More importantly, the risk of ICH increases in TT genotype individuals in comparison to CT and CC genotype individuals in Asian and Caucasian populations.

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