MTHFR A1298C gene polymorphism on stroke risk: an updated meta-analysis

Abstract

Background Previous studies have shown the effect of MTHFR A1298C gene polymorphism on stroke risk. But the results of published studies remained inconclusive and controversial. So we conducted a meta-analysis to accurately estimate the potential association between MTHFR A1298C gene polymorphism and stroke susceptibility. Methods A systematic literature search on Embase, Pubmed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI) and WanFang electronic database identified 40 articles including 5725 cases and 8655 controls. Strength of association was evaluated by pooled odds ratio (OR), 95% confidence interval (CI) and p value. Funnel plots and Begger’s regression test were applied for testing the publication bias. Statistical analysis of all data was performed by Stata 12.0. Results The meta-analysis results indicated a significant relationship between MTHFR gene A1298C polymorphisms and stoke risk under the C allelic genetic model (OR = 1.19, 95%CI = 1.07–1.32, p = 0.001), dominant genetic model (OR = 1.19, 95%CI = 1.06–1.33, p = 0.004) and recessive genetic model (OR = 1.43, 95%CI =1.15–1.77, p = 0.001). In subgroup analysis, we discovered obvious correlation in three genetic model of Asian, stroke type, adult by ethnicity, population, stroke type, source of control and case size. Additionally, in studies of control from hospital and case size equal 100, obvious correlation was also found in the three genetic model. Conclusions Our meta-analysis results indicated that there was evidence to support the correlation between MTHFR A1298C polymorphism and stroke susceptibility, especially in adults and ischemic stroke.

Homocysteine thiolactone and other sulfur-containing amino acid metabolites are associated with fibrin clot properties and the risk of ischemic stroke

“…The association of MTHFR A1298C polymorphism with brin clot properties has been reported before 26 . Although MTHFR A1298C polymorphism has been reported to be associated with stroke 27 , in the present study there was no association either in bivariate or logistic regression analyses (Table 5). However, in the present study we found that MTHFR C677T polymorphism was associated with stroke (Table 5), consistent with earlier studies 16 .…”

Association of two variants C677T and A1298C MTHFR gene polymorphisms with ischemic heart, ischemic stroke and venous thromboembolism diseases in a sample of Arabic Iraqi patients

“…For ischemic stroke, very recent meta-analysis estimated the potential relationship between MTHFR A1298 gene polymorphism and ischemic stroke susceptibility; this review involved 5725 cases versus 8655 controls in 40 studies, these results indicated the polymorphism in MTHFR A1298C gene has significant association with increase susceptibility of ischemic stroke under the C allelic genetic model. Additionally, in ethnic subgroup analysis MTHFR A1298C gene polymorphism was correlated with stroke risk of Asian populations, whereas there was no significant correlation among MTHFR A1298C gene polymorphism and increase risk of ischemic stroke in Caucasian and African populations (35).…”

Methylenetetrahydrofolate reductase polymorphisms and elevated plasma homocysteine levels in small vessel disease

“…Association of rs1801131 with tHcy and stroke susceptibility is inconsistent. In a meta-analysis including 5725 cases and 8655 controls, evidence supported a correlation between MTHFR rs1801131 and stroke susceptibility (Dong et al, 2021). However, few studies have focused on rs1801131 and SVD; indeed, only one study has shown an association between mutations at A1298C with decreased tHcy levels and reduced brain parenchymal fractions (Cao et al, 2021).…”