Methylenetetrahydrofolate Reductase Gene Polymorphism Is Not Related to the Risk of Ischemic Cerebrovascular Disease in a Brazilian Population

Abstract

reductase gene polymorphism is not related to the risk of ischemic cerebrovascular disease in the a Brazilian population. Clinics. 2007;62(3):295-300. PURPOSE:Data are conflicting concerning the risk for ischemic stroke associated with a common polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase C677T, which predisposes carriers to hyperhomocysteinemia. A meta-analysis study suggested that the 5,10-methylenetetrahydrofolate reductase 677TT genotype might have a small influence in determining susceptibility to ischemic stroke. METHODS: We analyzed the 5,10-methylenetetrahydrofolate reductase 677TT genotype polymorphism in Brazilian subjects with ischemic stroke, using a case-control design. RESULTS: We compared 5,10-methylenetetrahydrofolate reductase genotypes in groups of subjects presenting ischemic stroke (n = 127) and normal control (n = 126) and found an odds ratio of 1.97 (95% CI, 0.84-4.64) in a multivariate analysis in which results were adjusted to baseline clinical characteristics of study participants. CONCLUSION: We found that the homozygous 5,10-methylenetetrahydrofolate reductase C677T genotype was not a risk factor for ischemic stroke in these Brazilian subjects.

Ingestão de folato nos períodos pré e pós-fortificação mandatória: estudo de base populacional em São Paulo, Brasil

“…Nos Estados Unidos, em uma amostra nacional representativa, encontrou-se uma frequência de 11% de homozigotos TT para a MTHFR C677T na população 52 . No Brasil, estudos registraram uma frequência do homozigoto TT entre 9,5-10% 53,54 . Sabe-se que a presença do polimorfismo C677T no gene da MTHFR está associada à diminuição da atividade da enzima, elevação sanguínea de homocisteína e ao risco aumentado da ocorrência de agravos cardiovasculares, neoplasias e outras doenças, e que o estado nutricional adequado da vitamina parece modular esta associação 55 .…”

Relationship of Methylenetetrahydrofolate Reductase (MTHFR) C677T Variation With Susceptibility of Patients With Ischemic Stroke: A Meta-Analysis

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“…Subgroup -Caucasian studies: [40], [42], [79], [51], [58], [68], [34], [74], [36], [62], [59], [33], [50], [31], [49], [45], [37], [35], [77], [65], [38], [48], [84], [39], [67], [81].…”

Genetic Variants Involved in One-Carbon Metabolism: Polymorphism Frequencies and Differences in Homocysteine Concentrations in the Folic Acid Fortification Era

“…The prevalence of this genotype among white Americans was between 10% and 15%, and a lower prevalence of this genotype was observed for African and African-Americans, with 0% and 1%, respectively [ 4 , 17 , 18 ]. The results from case-control studies showed that the homozygote prevalence (TT) for this variant (677C>T) was 9.5% in control Brazilian individuals who were considered to be healthy [ 19 ], while the homozygote prevalence was 1.9% in individuals of African origin and 11.8% in individuals of Caucasian origin [ 20 ]. Herein, we observed that 11.3% of the population presented as being homozygous (TT) for the variant 677C>T, considering a homozygote prevalence of 13.2% and 1.6% among White and Black races, respectively.…”