Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population

Kalkan, Göknur; Yığıt, Serbülent; Karakuş, Nevin; Ateş, Ömer; Bozkurt, Nihan; Özdemir, Atiye; Pancar, Gunseli Sefika

doi:10.1016/j.gene.2013.08.016

Cited by 15 publications

(13 citation statements)

References 35 publications

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“…This principle is evidenced by a case-report [81] of a patient diagnosed with pernicious anemia at age 16 who later developed AA at age 24, and another report [73] of a patient who developed type 1 diabetes at age 18, 9 months later developed AA, and at age 27 was diagnosed with pernicious anemia. However, as mentioned previously, available case-control studies [72, 79, 80] with multiple AA cases did not identify any such differences in B 12 levels in patients compared to controls.…”

Section: Micronutrientsmentioning

confidence: 69%

“…Interestingly, in one AA genetic study, Kalkan et al [80] found that AA patients compared to controls had a higher prevalence of the C677T polymorphism (CT or TT vs. CC genotype) for the enzyme methylenetetrahydrofolate reductase (MTHFR), a key regulator of folate metabolism. The same polymorphism has been associated with other immune-mediated diseases including Graves’ disease [82] and multiple sclerosis [83].…”

Section: Micronutrientsmentioning

confidence: 99%

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The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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Alopecia areata (AA) is a common, non-scaring form of hair loss caused by immune-mediated attack of the hair follicle. As with other immune-mediated diseases, a complex interplay between environment and genetics is thought to lead to the development of AA. Deficiency of micronutrients such as vitamins and minerals may represent a modifiable risk factor associated with development of AA. Given their role in normal hair follicle development and in immune cell function, a growing number of investigations have sought to determine whether serum levels of these nutrients might differ in AA patients, and whether supplementation of these nutrients might represent a therapeutic option for AA. While current treatment often relies on invasive steroid injections or immunomodulating agents with potentially harmful side-effects, therapy by micronutrient supplementation, whether as a primary modality or as adjunctive treatment, could offer a promising low-risk alternative. However, our review highlights a need for further research in this area, given that the current body of literature largely consists of small case-control studies and case-reports which preclude any definite conclusions for a role of micronutrients in AA. In this comprehensive review of the current literature we found that serum vitamin D, zinc, and folate levels tend to be lower in patients with AA as compared to controls. Evidence is conflicting or insufficient to suggest differences in levels of iron, vitamin B12, copper, magnesium, or selenium. A small number of studies suggest that vitamin A levels may modify the disease. Though understanding of the role for micronutrients in AA is growing, definitive clinical recommendations such as routine serum level testing or therapeutic supplementation, call for additional studies in larger populations and with a prospective design.

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Section: Micronutrientsmentioning

confidence: 69%

Section: Micronutrientsmentioning

confidence: 99%

The Role of Micronutrients in Alopecia Areata: A Review

et al. 2017

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“…A study including 29 patients with AA that involved > 20% of the scalp showed that mean red blood cell folate concentrations were significantly lower in the patient group than in controls and significantly lower in patients with alopecia totalis/alopecia universalis than in patients with patchy hair loss [ 46 ]. Of interest, a genetic study including 136 Turkish patients with AA and 130 healthy controls found that the affected patients had a higher prevalence of mutations in the methylene-tetrahydrofolate reductase (MTHFR) gene [ 47 ]. This gene regulates folate metabolism, influences nucleic acid synthesis and DNA methylation, and is associated with other autoimmune disorders.…”

Section: Vitamin Bmentioning

confidence: 99%

“…These results suggest that mutations in MTHFR might impact the risk of AA in the Turkish population. However, there was no difference between serum levels of folate or vitamin B12 in affected patients and controls [ 47 ].…”

Section: Vitamin Bmentioning

confidence: 99%

The Role of Vitamins and Minerals in Hair Loss: A Review

Almohanna

Ahmed

Tsatalis

et al. 2018

Dermatol Ther (Heidelb)

168

143

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People commonly inquire about vitamin and mineral supplementation and diet as a means to prevent or manage dermatological diseases and, in particular, hair loss. Answering these queries is frequently challenging, given the enormous and conflicting evidence that exists on this subject. There are several reasons to suspect a role for micronutrients in non-scarring alopecia. Micronutrients are major elements in the normal hair follicle cycle, playing a role in cellular turnover, a frequent occurrence in the matrix cells in the follicle bulb that are rapidly dividing. Management of alopecia is an essential aspect of clinical dermatology given the prevalence of hair loss and its significant impact on patients’ quality of life. The role of nutrition and diet in treating hair loss represents a dynamic and growing area of inquiry. In this review we summarize the role of vitamins and minerals, such as vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, iron, selenium, and zinc, in non-scarring alopecia. A broad literature search of PubMed and Google Scholar was performed in July 2018 to compile published articles that study the relationship between vitamins and minerals, and hair loss. Micronutrients such as vitamins and minerals play an important, but not entirely clear role in normal hair follicle development and immune cell function. Deficiency of such micronutrients may represent a modifiable risk factor associated with the development, prevention, and treatment of alopecia. Given the role of vitamins and minerals in the hair cycle and immune defense mechanism, large double-blind placebo-controlled trials are required to determine the effect of specific micronutrient supplementation on hair growth in those with both micronutrient deficiency and non-scarring alopecia to establish any association between hair loss and such micronutrient deficiency. Plain Language Summary: Plain language summary available for this article.

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“…But for MTR A2756G and MTRR A66G polymorphisms, there are not enough studies. Hence, further studies are need to be conducted (Table 1) [39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58]. …”

Section: Genetic Susceptibility and The Risk Of Msmentioning

confidence: 99%

The Role of Folate Dependent Genetic Susceptibility in The Risk of Multiple Sclerosis

Asci¹,

Karahalıl²

2017

J Neurol Neurosci

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Background: Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) of unknown cause. Epidemiological studies implicate that genetic and environmental factors interplay major roles in the etiology of MS. Several investigators have reported elevated plasma homocysteine and reduced folate and B vitamin levels in MS. Aberrations in one-carbon metabolism have impact in the pathophysiology by genetic susceptibility and increased the risk of MS. Furthermore, abnormalities in a carbon metabolism pathway may result from environmental factors such as reduced levels of vitamin B and folate due to inadequate B vitamin and folate intake from foods or the problems on their synthesis, and genetic factors such as polymorphism in folate -dependent enzymes.

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Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population

Cited by 15 publications

References 35 publications

The Role of Micronutrients in Alopecia Areata: A Review

The Role of Micronutrients in Alopecia Areata: A Review

The Role of Vitamins and Minerals in Hair Loss: A Review

The Role of Folate Dependent Genetic Susceptibility in The Risk of Multiple Sclerosis

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